In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions

NCT ID: NCT03371641

Last Updated: 2017-12-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-27

Study Completion Date

2025-01-27

Brief Summary

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This study aims to validate that PLGF is a biomarker of cerebral lesions and therefore of secondary developmental disorders and disabilities that will be best diagnosed at 2 and 6 years of age.

Detailed Description

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Conditions

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Fetal Alcohol Syndrome

Keywords

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Fetal Alcohol Syndrome Pregnancy Biomarker PlGF Cognitive development Behavior troubles

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Alcoholic exposure group

Blood sample (mother) Cord blood sample Placenta sample ASQ parental questionnaire WPPSI - IV and NEPSY development scales Scale of Conners SCQ questionnaire

Group Type OTHER

ASQ parental questionnaire

Intervention Type BEHAVIORAL

ASQ parental questionnaire

Development scales

Intervention Type BEHAVIORAL

WPPSI - IV and NEPSY development scales

Scale of Conners

Intervention Type BEHAVIORAL

Scale of Conners

SCQ Questionnaire

Intervention Type BEHAVIORAL

SCQ questionnaire

Blood sample (mother)

Intervention Type PROCEDURE

Blood sample (mother) before delivery

Cord blood sample

Intervention Type PROCEDURE

Cord blood sample after delivery

Placenta sample

Intervention Type PROCEDURE

Placenta sample

Control

Blood sample (mother) Cord blood sample Placenta sample ASQ parental questionnaire WPPSI - IV and NEPSY development scales Scale of Conners SCQ questionnaire

Group Type OTHER

ASQ parental questionnaire

Intervention Type BEHAVIORAL

ASQ parental questionnaire

Development scales

Intervention Type BEHAVIORAL

WPPSI - IV and NEPSY development scales

Scale of Conners

Intervention Type BEHAVIORAL

Scale of Conners

SCQ Questionnaire

Intervention Type BEHAVIORAL

SCQ questionnaire

Blood sample (mother)

Intervention Type PROCEDURE

Blood sample (mother) before delivery

Cord blood sample

Intervention Type PROCEDURE

Cord blood sample after delivery

Placenta sample

Intervention Type PROCEDURE

Placenta sample

Interventions

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ASQ parental questionnaire

ASQ parental questionnaire

Intervention Type BEHAVIORAL

Development scales

WPPSI - IV and NEPSY development scales

Intervention Type BEHAVIORAL

Scale of Conners

Scale of Conners

Intervention Type BEHAVIORAL

SCQ Questionnaire

SCQ questionnaire

Intervention Type BEHAVIORAL

Blood sample (mother)

Blood sample (mother) before delivery

Intervention Type PROCEDURE

Cord blood sample

Cord blood sample after delivery

Intervention Type PROCEDURE

Placenta sample

Placenta sample

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Mother:

* Pregnant woman (monofetal or twin pregnancy, whatever the parity)
* Age\> or = to 18 years
* Person affiliated to a social security system
* Person who read and understood the information form and signed the consent form

* Alcohol exposure group Chronic consumption of at least 30 g of alcohol per week or acute consumption of "binge drinking" type during pregnancy (knowing that a unit of 10 g of pure alcohol corresponds to 25 cl of beer 4 ° 5, 10 cl of wine at 12 °, 3 cl of whiskey, 7 cl of Porto ...)
* Control group No alcohol consumption during pregnancy
* Child Informed parents and written consent signed by the father and mother for the child's participation in this research (unless one of the parents does not have parental authority)

Exclusion Criteria

* Female under 18
* Pregnant woman with clinical suspicion of pre-eclampsia and / or HELLP syndrome
* Person deprived of liberty by an administrative or judicial decision or protected major subject (under tutorship or curatorship)
* Patient participating in another interventional trial or who participated in another interventional trial during pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Rouen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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UH ROUEN

Rouen, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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POURCHER

Role: CONTACT

Phone: 02 32 88 82 65

Email: [email protected]

BLOT

Role: CONTACT

Phone: 02 32 88 82 65

Email: [email protected]

Facility Contacts

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POURCHER

Role: primary

BLOT

Role: backup

Other Identifiers

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2016/337/HP

Identifier Type: -

Identifier Source: org_study_id