How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes

NCT ID: NCT03370861

Last Updated: 2024-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

54 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-08

Study Completion Date

2022-12-31

Brief Summary

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The purpose of this research study is to examine the relationship between the microbiota (microscopic organisms) in the gut and the activity of the immune system during skin cancer immunotherapy.

Detailed Description

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Details will be available upon publication.

Conditions

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Autoimmunity Melanoma Merkel Cell Carcinoma Squamous Cell Carcinoma of the Skin Basal Cell Carcinoma Skin Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Immunotherapy

Medications that increase the activity of the immune system.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* ≥18 years of age.
* Diagnosis of skin cancer.
* Planning to initiate or already on ANY type of immunotherapy.
* Able to provide urine and stool specimens.

Exclusion Criteria

* Bowel resection.
* Major GI surgery in the past 5 years other than cholecystectomy and appendectomy.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Washington University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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William H. McCoy IV, MD, PhD

Research Instructor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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William H McCoy IV, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine

Locations

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Barnes-Jewish Hosptial

St Louis, Missouri, United States

Site Status

Countries

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United States

Other Identifiers

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MINING

Identifier Type: -

Identifier Source: org_study_id

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