Food Preference Following Bariatric Surgery

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

34 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-12-15

Study Completion Date

2021-09-30

Brief Summary

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Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.

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Detailed Description

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Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. If true, this could conceivably contribute to improved glycemia and body weight. Disparities among studies on food selection and intake are likely due to the almost complete reliance on self-reported food intake which is vulnerable to inaccuracy.This controversy can best be resolved by complementing existing findings with direct measures of target behaviour in humans. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.

Conditions

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Obesity

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Gastric bypass

Obese patients due to undergo gastric bypass surgery

Food Preference

Intervention Type BEHAVIORAL

Buffet meal to assess food preference

Control

Healthy free-living individuals

Food Preference

Intervention Type BEHAVIORAL

Buffet meal to assess food preference

Interventions

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Food Preference

Buffet meal to assess food preference

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Surgical and non-surgical groups:

A) Bariatric surgery B) Controls with no history of bariatric surgery
2. Independently mobile
3. Capacity to consent to participate
4. \>18 years of age

Exclusion Criteria

1. Pre-operatively: significant dysphagia, gastric outlet obstruction or anything that prevents subjects from eating a meal.
2. Post-operatively: significant and persistent surgical complications or anything that prevents subjects from eating a meal.
3. Systemic or gastrointestinal condition which may affect food intake or preference, including:

i) pregnancy or ii) breast feeding.
4. Active and significant psychiatric illness including substance misuse
5. Significant cognitive or communication issues
6. Medications with documented effect on food intake or food preference
7. History of significant food allergy and certain dietary restrictions
8. History of liver disease or pancreatitis
9. History of bradyarrythmia or congestive cardiac failure group)
10. Use of medications with potential serious interactions with Octreotide

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes