MedDataX Logo

German Stroke Registry - Endovascular Treatment

NCT ID: NCT03356392

Last Updated: 2024-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

10000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Study Completion Date

2027-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The German Stroke Registry (GSR) Endovascular Treatment is an academic, independent, prospective, multicentre, observational registry study. Consecutive patients treated with endovascular stroke treatment will be enrolled in German stroke centers. Patients receive regular care and data will be collected as part of clinical routine. Baseline clinical and procedural information as well clinical follow-up information during in-hospital stay, and up to 90 days of stroke onset are collected. Data collected include demographics, National Institute of Health Stroke Scale (NIHSS) on admission, pre-treatment ASPECTS, information on timing and success of interventional treatment, procedural complications, intracranial hemorrhage, and functional outcome.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Ischemic Stroke

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

acute stroke, thrombectomy, endovascular treatment

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

stroke patients

acute stroke patients treated with endovascular treatment combined with or without

telephone call d90

Intervention Type OTHER

telephone call on day 90 to assess the primary outcome (mRs d90)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

telephone call d90

telephone call on day 90 to assess the primary outcome (mRs d90)

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Clinical diagnosis of acute ischemic stroke
* Eligible for intravenous thrombolysis (IVT) and IVT initiated within 4.5 hours after stroke onset
* Confirmed diagnosis of persistent occlusion of terminal carotid artery, middle cerebral artery (M1 or M2), or basilar artery consistent with symptoms
* Age \>18 years
* Ethic approval in process
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University Hospital of Cologne

OTHER

Sponsor Role collaborator

Klinikum rechts der Isar, Technical University of Munich

UNKNOWN

Sponsor Role collaborator

RWTH Aachen University

OTHER

Sponsor Role collaborator

University Hospital Tuebingen

OTHER

Sponsor Role collaborator

Charite University, Berlin, Germany

OTHER

Sponsor Role collaborator

Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum

UNKNOWN

Sponsor Role collaborator

Sana Klinikum Offenbach

OTHER

Sponsor Role collaborator

Goethe University

OTHER

Sponsor Role collaborator

Klinikum Dortmund

UNKNOWN

Sponsor Role collaborator

KRH Klinikum Nordstadt

UNKNOWN

Sponsor Role collaborator

Asklepios Klinik Altona

UNKNOWN

Sponsor Role collaborator

Klinikum Altenburger Land

UNKNOWN

Sponsor Role collaborator

Klinikum Stadt Hanau

OTHER

Sponsor Role collaborator

Klinikum Lüneburg

UNKNOWN

Sponsor Role collaborator

Ludwig-Maximilians - University of Munich

OTHER

Sponsor Role collaborator

University of Göttingen

OTHER

Sponsor Role collaborator

Krankenhaus Buchholz

UNKNOWN

Sponsor Role collaborator

Klinikum Osnabrück

UNKNOWN

Sponsor Role collaborator

Wuerzburg University Hospital

OTHER

Sponsor Role collaborator

University of Giessen and Marburg

UNKNOWN

Sponsor Role collaborator

Sana Kliniken Lübeck

UNKNOWN

Sponsor Role collaborator

Mühlenkreiskliniken Minden

UNKNOWN

Sponsor Role collaborator

radprax MVZ Nordrhein

UNKNOWN

Sponsor Role collaborator

University Hospital Muenster

OTHER

Sponsor Role collaborator

University Medical Center Rostock

OTHER

Sponsor Role collaborator

Asklepios Klinik Wandsbek

UNKNOWN

Sponsor Role collaborator

Elbe Kliniken

UNKNOWN

Sponsor Role collaborator

Städtische Klinikum Braunschweig

UNKNOWN

Sponsor Role collaborator

Allgemeines Krankenhaus Celle

UNKNOWN

Sponsor Role collaborator

Bezirkskrankenhaus Günzburg

UNKNOWN

Sponsor Role collaborator

Klinikum Bremen-Mitte, gGmbH

OTHER

Sponsor Role collaborator

University Medical Center Mainz

OTHER

Sponsor Role collaborator

Klinikum Köln-Merheim

UNKNOWN

Sponsor Role collaborator

University Hospital, Bonn

OTHER

Sponsor Role collaborator

Universitätsklinikum Hamburg-Eppendorf

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Martin Dichgans, Prof. Dr. med.

Role: PRINCIPAL_INVESTIGATOR

LMU, Munich, Germany

Christian Gerloff, Prof. Dr. med.

Role: PRINCIPAL_INVESTIGATOR

UKE, Hamburg, Germany

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University Medical Center Hamburg-Eppendorf (UKE)

Hamburg, City state of Hamburg, Germany

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Germany

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Maximilian Schell

Role: CONTACT

Phone: +49 (0)1522/2834807

Email: [email protected]

Götz Thomalla, Prof. Dr. med.

Role: CONTACT

Phone: +49 (0)40/7410-0

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Maximilian Schell

Role: primary

Götz Thomalla, Prof. Dr. med.

Role: backup

Christian Gerloff, Prof. Dr. med.

Role: backup

References

Explore related publications, articles, or registry entries linked to this study.

Deb-Chatterji M, Pinho J, Flottmann F, Meyer L, Broocks G, Brekenfeld C, Reich A, Fiehler J, Gerloff C, Thomalla G; GSR-ET Investigators. Health-related quality of life after thrombectomy in young-onset versus older stroke patients: a multicenter analysis. J Neurointerv Surg. 2022 Nov;14(11):1145-1150. doi: 10.1136/neurintsurg-2021-017991. Epub 2021 Dec 7.

Reference Type BACKGROUND
PMID: 34876497 (View on PubMed)

Kniep H, Bechstein M, Broocks G, Brekenfeld C, Flottmann F, van Horn N, Geest V, Faizy TD, Deb-Chatterji M, Alegiani A, Thomalla G, Gellissen S, Fiehler J, Hanning U, Meyer L; German Stroke Registry-Endovascular Treatment (GSR-ET). Early surrogates of outcome after thrombectomy in posterior circulation stroke. Eur J Neurol. 2022 Nov;29(11):3296-3306. doi: 10.1111/ene.15519. Epub 2022 Aug 28.

Reference Type BACKGROUND
PMID: 35933692 (View on PubMed)

Hahn M, Groschel S, Lang LS, Othman AE, Groschel K, Uphaus T; German Stroke Registry - Endovascular Treatment (GSR-ET) investigators. Mortality within three months after nonfatal ischemic stroke treated by mechanical thrombectomy in routine care-data from the German Stroke Registry. Neurol Res Pract. 2025 Oct 1;7(1):71. doi: 10.1186/s42466-025-00427-7.

Reference Type DERIVED
PMID: 41035079 (View on PubMed)

Tong X, Jia B, Ma G, Zhang X, Fiehler J, Flottmann F, Bechstein M, Broocks G, Hanning U, Kniep HC, Thomalla G, Deb-Chatterji M, Schon G, Zhang Y, Gao F, Ma N, Mo D, Miao Z, Meyer L; as the ANGEL-ACT & GSR-ET study group. Relationship Between Thrombolysis-to-Puncture Time and Outcomes of Endovascular Thrombectomy in Acute Ischemic Stroke. Neurol Clin Pract. 2025 Aug;15(4):e200434. doi: 10.1212/CPJ.0000000000200434. Epub 2025 Jul 11.

Reference Type DERIVED
PMID: 40656129 (View on PubMed)

Heitkamp A, Hierholzer SM, Heitkamp C, Winkelmeier L, Meyer L, Bechstein M, Geest V, Broocks G, Brekenfeld C, Flottmann F, Schell M, Thomalla G, Faizy T, Fiehler J, Kniep HC, Gellissen S; German Stroke Registry -Endovascular Treatment (GSR-ET). Key to better outcomes in stroke intervention: early versus complete reperfusion in first pass recanalization. J Neurol. 2025 Jul 11;272(8):504. doi: 10.1007/s00415-025-13235-5.

Reference Type DERIVED
PMID: 40646337 (View on PubMed)

Single C, Mengel A, Laichinger K, Sartor-Pfeiffer J, Selo N, Hennersdorf F, Bender B, Deb-Chatterji M, Thomalla G, Mbroh J, Poli S, Ziemann U, Ernemann U, Feil K; German Stroke Registry-Endovascular Treatment (GSR). Sex-Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke-Analyses From the German Stroke Registry-Endovascular Treatment. Eur J Neurol. 2025 Mar;32(3):e70092. doi: 10.1111/ene.70092.

Reference Type DERIVED
PMID: 40008680 (View on PubMed)

Beckonert NM, Weller JM, Alegiani AC, Boeckh-Behrens T, Deb-Chatterji M, Hamann GF, Krause LU, Lehnen NC, Nitsch L, Poli S, Riedel C, Tiedt S, Zweynert S, Petzold GC, Dorn F, Bode FJ; GSR-ET investigators. Endovascular treatment of primary M3 occlusion stroke in clinical practice: analysis of the German Stroke Registry. Neurol Res Pract. 2024 Jul 18;6(1):36. doi: 10.1186/s42466-024-00330-7.

Reference Type DERIVED
PMID: 39020409 (View on PubMed)

Winkelmeier L, Heitkamp C, Faizy TD, Broocks G, Kniep H, Meyer L, Bester M, Brekenfeld C, Schell M, Hanning U, Thomalla G, Fiehler J, Flottmann F. Prognostic value of recanalization attempts in endovascular therapy for M2 segment middle cerebral artery occlusions. Int J Stroke. 2024 Apr;19(4):422-430. doi: 10.1177/17474930231214769. Epub 2023 Nov 22.

Reference Type DERIVED
PMID: 37935652 (View on PubMed)

Kniep H, Meyer L, Broocks G, Bechstein M, Guerreiro H, Winkelmeier L, Brekenfeld C, Flottmann F, Deb-Chatterji M, Alegiani A, Hanning U, Thomalla G, Fiehler J, Gellissen S; German Stroke Registry - Endovascular Treatment (GSR - ET). Predictors of functional outcome after thrombectomy for M2 occlusions: a large scale experience from clinical practice. Sci Rep. 2023 Oct 31;13(1):18740. doi: 10.1038/s41598-023-45232-x.

Reference Type DERIVED
PMID: 37907482 (View on PubMed)

Winkelmeier L, Faizy TD, Brekenfeld C, Heitkamp C, Broocks G, Bechstein M, Steffen P, Schell M, Gellissen S, Kniep H, Thomalla G, Fiehler J, Flottmann F; German Stroke Registry - Endovascular Treatment (GSR). Comparison of Thrombolysis In Cerebral Infarction (TICI) 2b and TICI 3 reperfusion in endovascular therapy for large ischemic anterior circulation strokes. J Neurointerv Surg. 2024 Oct 14;16(11):1076-1082. doi: 10.1136/jnis-2023-020724.

Reference Type DERIVED
PMID: 37777256 (View on PubMed)

Winkelmeier L, Faizy TD, Broocks G, Meyer L, Heitkamp C, Brekenfeld C, Thaler C, Steffen P, Schell M, Deb-Chatterji M, Hanning U, Kniep H, Maros ME, Thomalla G, Fiehler J, Flottmann FA; German Stroke Registry. Association Between Recanalization Attempts and Functional Outcome After Thrombectomy for Large Ischemic Stroke. Stroke. 2023 Sep;54(9):2304-2312. doi: 10.1161/STROKEAHA.123.042794. Epub 2023 Jul 26.

Reference Type DERIVED
PMID: 37492970 (View on PubMed)

Hahn M, Groschel S, Othman A, Brockstedt L, Civelek A, Brockmann MA, Groschel K, Uphaus T; German Stroke Registry Endovascular Treatment-Steering Committee. Real world data in mechanical thrombectomy: who are we losing to follow-up? J Neurointerv Surg. 2024 Apr 23;16(5):471-477. doi: 10.1136/jnis-2023-020435.

Reference Type DERIVED
PMID: 37460214 (View on PubMed)

Weller JM, Dorn F, Meissner JN, Stosser S, Beckonert NM, Nordsiek J, Kindler C, Riegler C, Keil F, Petzold GC, Bode FJ; GSR-ET investigators. Antithrombotic treatment and outcome after endovascular treatment and acute carotid artery stenting in stroke patients with atrial fibrillation. Neurol Res Pract. 2022 Sep 12;4(1):42. doi: 10.1186/s42466-022-00207-7.

Reference Type DERIVED
PMID: 36089621 (View on PubMed)

Weller JM, Dorn F, Meissner JN, Stosser S, Beckonert NM, Nordsiek J, Kindler C, Deb-Chatterji M, Petzold GC, Bode FJ; GSR-ET investigators. Endovascular thrombectomy in young patients with stroke. Int J Stroke. 2023 Apr;18(4):453-461. doi: 10.1177/17474930221119602. Epub 2022 Sep 7.

Reference Type DERIVED
PMID: 35912650 (View on PubMed)

Kniep H, Meyer L, Bechstein M, Broocks G, Guerreiro H, van Horn N, Brekenfeld C, Flottmann F, Deb-Chatterji M, Alegiani A, Thomalla G, Hanning U, Fiehler J, Gellissen S; GSR-ET (German Stroke Registry-Endovascular Treatment). How Much of the Thrombectomy Related Improvement in Functional Outcome Is Already Apparent at 24 Hours and at Hospital Discharge? Stroke. 2022 Sep;53(9):2828-2837. doi: 10.1161/STROKEAHA.121.037888. Epub 2022 May 13.

Reference Type DERIVED
PMID: 35549377 (View on PubMed)

Hahn M, Groschel S, Hayani E, Brockmann MA, Muthuraman M, Groschel K, Uphaus T; German Stroke Registry-Endovascular Treatment (GSR-ET) Study Group. Sex Disparities in Re-Employment in Stroke Patients With Large Vessel Occlusion Undergoing Mechanical Thrombectomy. Stroke. 2022 Aug;53(8):2528-2537. doi: 10.1161/STROKEAHA.121.037386. Epub 2022 Apr 21.

Reference Type DERIVED
PMID: 35443786 (View on PubMed)

Meyer L, Bechstein M, Bester M, Hanning U, Brekenfeld C, Flottmann F, Kniep H, van Horn N, Deb-Chatterji M, Thomalla G, Sporns P, Yeo LL, Tan BY, Gopinathan A, Kastrup A, Politi M, Papanagiotou P, Kemmling A, Fiehler J, Broocks G; German Stroke Registry-Endovascular Treatment (GSR-ET). Thrombectomy in Extensive Stroke May Not Be Beneficial and Is Associated With Increased Risk for Hemorrhage. Stroke. 2021 Oct;52(10):3109-3117. doi: 10.1161/STROKEAHA.120.033101. Epub 2021 Sep 2.

Reference Type DERIVED
PMID: 34470489 (View on PubMed)

Weller JM, Enkirch SJ, Bogs C, Braemswig TB, Deb-Chatterji M, Keil F, Kindler C, Maywald S, Schirmer MD, Stosser S, Solymosi L, Nolte CH, Bode FJ, Petzold GC; GSR-ET Investigators. Endovascular Treatment for Acute Stroke in Cerebral Amyloid Angiopathy. Stroke. 2021 Oct;52(10):e581-e585. doi: 10.1161/STROKEAHA.120.033014. Epub 2021 Aug 20.

Reference Type DERIVED
PMID: 34412512 (View on PubMed)

Maros ME, Brekenfeld C, Broocks G, Leischner H, McDonough R, Deb-Chatterji M, Alegiani A, Thomalla G, Fiehler J, Flottmann F; GSR Investigators*. Number of Retrieval Attempts Rather Than Procedure Time Is Associated With Risk of Symptomatic Intracranial Hemorrhage. Stroke. 2021 May;52(5):1580-1588. doi: 10.1161/STROKEAHA.120.031242. Epub 2021 Apr 5.

Reference Type DERIVED
PMID: 33813864 (View on PubMed)

Herm J, Schlemm L, Siebert E, Bohner G, Alegiani AC, Petzold GC, Pfeilschifter W, Tiedt S, Kellert L, Endres M, Nolte CH. How do treatment times impact on functional outcome in stroke patients undergoing thrombectomy in Germany? Results from the German Stroke Registry. Int J Stroke. 2021 Oct;16(8):953-961. doi: 10.1177/1747493020985260. Epub 2021 Jan 20.

Reference Type DERIVED
PMID: 33472575 (View on PubMed)

Flottmann F, Brekenfeld C, Broocks G, Leischner H, McDonough R, Faizy TD, Deb-Chatterji M, Alegiani A, Thomalla G, Mpotsaris A, Nolte CH, Fiehler J, Maros ME; GSR investigators*. Good Clinical Outcome Decreases With Number of Retrieval Attempts in Stroke Thrombectomy: Beyond the First-Pass Effect. Stroke. 2021 Jan;52(2):482-490. doi: 10.1161/STROKEAHA.120.029830. Epub 2021 Jan 20.

Reference Type DERIVED
PMID: 33467875 (View on PubMed)

Kupper C, Feil K, Wollenweber FA, Tiedt S, Herzberg M, Dorn F, Liebig T, Dieterich M, Kellert L; GSR investigators. Endovascular stroke treatment in orally anticoagulated patients: an analysis from the German Stroke Registry-Endovascular Treatment. J Neurol. 2021 May;268(5):1762-1769. doi: 10.1007/s00415-020-10369-6. Epub 2020 Dec 29.

Reference Type DERIVED
PMID: 33373024 (View on PubMed)

Ettelt P, Maier IL, Schnieder M, Bahr M, Behme D, Psychogios MN, Liman J; GSR-ET Collaborators. Bridging therapy is associated with improved cognitive function after large vessel occlusion stroke - an analysis of the German Stroke Registry. Neurol Res Pract. 2020 Jul 27;2:29. doi: 10.1186/s42466-020-00079-9. eCollection 2020.

Reference Type DERIVED
PMID: 33324931 (View on PubMed)

Wollenweber FA, Tiedt S, Alegiani A, Alber B, Bangard C, Berrouschot J, Bode FJ, Boeckh-Behrens T, Bohner G, Bormann A, Braun M, Dorn F, Eckert B, Flottmann F, Hamann GF, Henn KH, Herzberg M, Kastrup A, Kellert L, Kraemer C, Krause L, Lehm M, Liman J, Lowens S, Mpotsaris A, Papanagiotou P, Petersen M, Petzold GC, Pfeilschifter W, Psychogios MN, Reich A, von Rennenberg R, Rother J, Schafer JH, Siebert E, Siedow A, Solymosi L, Thonke S, Wagner M, Wunderlich S, Zweynert S, Nolte CH, Gerloff C, Thomalla G, Dichgans M, Fiehler J. Functional Outcome Following Stroke Thrombectomy in Clinical Practice. Stroke. 2019 Sep;50(9):2500-2506. doi: 10.1161/STROKEAHA.119.026005. Epub 2019 Jul 24.

Reference Type DERIVED
PMID: 31337298 (View on PubMed)

Alegiani AC, Dorn F, Herzberg M, Wollenweber FA, Kellert L, Siebert E, Nolte CH, von Rennenberg R, Hattingen E, Petzold GC, Bode FJ, Pfeilschifter W, Schafer JH, Wagner M, Rother J, Eckert B, Kraft P, Pham M, Boeckh-Behrens T, Wunderlich S, Bernkopf K, Reich A, Wiesmann M, Mpotsaris A, Psychogios M, Liman J, Maier I, Berrouschot J, Bormann A, Limmroth V, Spreer J, Petersen M, Krause L, Lowens S, Kraemer C, Zweynert S, Lange KS, Thonke S, Kastrup A, Papanagiotou P, Alber B, Braun M, Fiehler J, Gerloff C, Dichgans M, Thomalla G. Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment. Int J Stroke. 2019 Jun;14(4):372-380. doi: 10.1177/1747493018806199. Epub 2018 Oct 22.

Reference Type DERIVED
PMID: 30346260 (View on PubMed)

Related Links

Access external resources that provide additional context or updates about the study.

https://www.german-stroke-registry.de/german-stroke-registry

Homepage of German Stroke Registry

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

GSR-ET

Identifier Type: -

Identifier Source: org_study_id