Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Changes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

22000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-01

Study Completion Date

2016-03-01

Brief Summary

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the investigators tested whether genetic variants near FADS cluster, which were recently identified to be signatures of adaptation to fish- and n-3 PUFAs-rich diet, interacted with these dietary factors on long-term change of body mass index (BMI).

Detailed Description

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Conditions

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Obesity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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fish

fish intkae

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 11,323 women of European ancestry.
* Informed consent was obtained from all participants. The DNA extraction methods, quality control measures,
* SNPs genotyping and imputation data are available .
* Both cases and controls with genotyping data are available based on GWASs

Exclusion Criteria

* participants without genetic data

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

References

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Heianza Y, Qi L. Gene-Diet Interaction and Precision Nutrition in Obesity. Int J Mol Sci. 2017 Apr 7;18(4):787. doi: 10.3390/ijms18040787.

Reference Type BACKGROUND

PMID: 28387720 (View on PubMed)

Qi Q, Chu AY, Kang JH, Huang J, Rose LM, Jensen MK, Liang L, Curhan GC, Pasquale LR, Wiggs JL, De Vivo I, Chan AT, Choi HK, Tamimi RM, Ridker PM, Hunter DJ, Willett WC, Rimm EB, Chasman DI, Hu FB, Qi L. Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ. 2014 Mar 19;348:g1610. doi: 10.1136/bmj.g1610.

Reference Type BACKGROUND

PMID: 24646652 (View on PubMed)

Other Identifiers

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NHS25487541

Identifier Type: -

Identifier Source: org_study_id