Vectors Post Market: A Study to Assess Pain Relief Using Spinal Cord Stimulation

NCT ID: NCT03345472

Last Updated: 2020-11-03

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

175 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-11-30

Study Completion Date

2019-10-21

Brief Summary

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This is a prospective, single-arm, multi-center study evaluating the efficacy of spinal cord stimulation (SCS) therapy for pain relief using high dose (HD) stimulation parameters delivered to neural targets identified during current commercial trial stimulation procedures. The study will evaluate changes in back and leg pain from baseline to 3, 6, and 12 months.

Detailed Description

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Conditions

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Chronic Pain

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treated

Enrolled subjects who are implanted with a spinal cord stimulation system that is activated.

Group Type EXPERIMENTAL

Spinal Cord Stimulation System

Intervention Type DEVICE

Implanted neurostimulation system (neurostimulator and leads) with high dose stimulation parameters.

Interventions

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Spinal Cord Stimulation System

Implanted neurostimulation system (neurostimulator and leads) with high dose stimulation parameters.

Intervention Type DEVICE

Other Intervention Names

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Medtronic RestoreSensor SureScan MRI neurostimulation system Medtronic Intellis AdaptiveStim neurostimulation system

Eligibility Criteria

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Inclusion Criteria

* Candidate per labeling for an SCS system as an aid in the management of chronic, intractable low back and leg pain
* Presence of low back and leg pain
* Moderate to crippled disability due to pain
* Stable pain medications for back and leg pain for at least 28 days prior to enrollment
* Willing and able to not increase pain medications through the 3-Month visit

Exclusion Criteria

* Previously trialed or implanted with stimulator or intrathecal drug delivery system
* Current diagnosis of moderate to severe central lumbar spinal stenosis
* Major psychiatric comorbidity or other progressive diseases
* Serious drug-related behavioral issues
* Pregnant or planning on becoming pregnant
* Unable to achieve supine position
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MedtronicNeuro

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vectors Post Market Clinical Research Study Team

Role: STUDY_DIRECTOR

Medtronic Restorative Therapies, Pain Therapy

Locations

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Pain Consultants of San Diego

La Mesa, California, United States

Site Status

Restore Orthopedics and Spine Center

Orange, California, United States

Site Status

Center for Interventional Pain and Spine

Wilmington, Delaware, United States

Site Status

Pain Care

Stockbridge, Georgia, United States

Site Status

National Spine and Pain

Oxon Hill, Maryland, United States

Site Status

Michigan Pain Consultants

Wyoming, Michigan, United States

Site Status

Comprehensive and Interventional Pain Management

Henderson, Nevada, United States

Site Status

The Pain Management Center

Voorhees Township, New Jersey, United States

Site Status

University of Rochester Neurosurgery Partners Pain Management

Rochester, New York, United States

Site Status

Carolinas Pain Center

Huntersville, North Carolina, United States

Site Status

The Ohio State University Wexner Medical Center

Columbus, Ohio, United States

Site Status

Lehigh Valley Healthcare Network

Allentown, Pennsylvania, United States

Site Status

Saint Luke's Neurosurgical Associates

Bethlehem, Pennsylvania, United States

Site Status

Pain Diagnostics and Interventional Care

Sewickley, Pennsylvania, United States

Site Status

Delaware Valley Pain and Spine Institute

Trevose, Pennsylvania, United States

Site Status

Lowcountry Orthopaedics/Coastal Carolina Research Center

Charleston, South Carolina, United States

Site Status

Carolina Center for Advanced Management of Pain

Spartanburg, South Carolina, United States

Site Status

Precision Spine Care

Tyler, Texas, United States

Site Status

Carilion Clinic Roanoke Memorial Hospital

Roanoke, Virginia, United States

Site Status

Northwest Pain Care

Spokane, Washington, United States

Site Status

Countries

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United States

References

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Hatheway JA, Mangal V, Fishman MA, Kim P, Shah B, Vogel R, Galan V, Severyn S, Weaver TE, Provenzano DA, Chang E, Verdolin MH, Howes G, Villarreal A, Falowski S, Hendrickson K, Stromberg K, Davies L, Johanek L, Kelly MT. Long-Term Efficacy of a Novel Spinal Cord Stimulation Clinical Workflow Using Kilohertz Stimulation: Twelve-Month Results From the Vectors Study. Neuromodulation. 2021 Apr;24(3):556-565. doi: 10.1111/ner.13324. Epub 2020 Dec 9.

Reference Type DERIVED
PMID: 33296127 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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MDT17053

Identifier Type: -

Identifier Source: org_study_id