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The Effects of Early Life PUFA and R-TFA on AD: A Systematic Review and Meta-analysis

NCT ID: NCT03344783

Last Updated: 2017-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

26 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-03-15

Study Completion Date

2017-10-10

Brief Summary

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The purpose of this study is to evaluate whether early life natural exposure to fatty acid affects the AD risk.

Detailed Description

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The prevalence of Allergic Diseases (AD) is rising dramatically worldwide especially in more industrialized countries during the past two decades, representing a substantial disease burden of individuals and health service cost. Early life nutritional exposures could modify the gene expression and susceptibility of allergic diseases (AD), yet the effects of early life polyunsaturated fatty acids (PUFA) and ruminant trans fatty acids (R-TFA) on AD remain unclear.Therefore,the investigators performed the meta-analysis and systematic review to evaluate whether early life natural exposure to PUFA and R-TFA affects the AD risk.

Conditions

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Allergic Disorder

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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mother-children pairs

PUFA and R-TFA

Intervention Type OTHER

PUFA and R-TFA exposure were assessed mainly from maternal dietary, blood sample or breast milk. Exposure period was restricted to early life. Dietary PUFA and R-TFA were measured by food-frequency questionnaire (FFQ) or diet history questionnaire (DHQ). The profile of PUFA and R-TFA in the blood sample and breast milk were examined by using gas chromatography

Interventions

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PUFA and R-TFA

PUFA and R-TFA exposure were assessed mainly from maternal dietary, blood sample or breast milk. Exposure period was restricted to early life. Dietary PUFA and R-TFA were measured by food-frequency questionnaire (FFQ) or diet history questionnaire (DHQ). The profile of PUFA and R-TFA in the blood sample and breast milk were examined by using gas chromatography

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Studies needed to provide endpoints of AD, and risk estimates \[odds risk (OR), relative risk (RR) or hazard ratio (HR)\] for PUFA or R-TFA as the exposure. We included English language articles only, while scanned titles /abstracts of non-English language articles to evaluate agreement with the results published in English.

Exclusion Criteria

* Studies were excluded if they didn't report the profile of PUFA or R-TFA, or if they targeted participants with medical condition.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Li Cai

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Li Cai, PhD

Role: STUDY_CHAIR

Sun Yat-sen University

Locations

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Weijia, Wu

Guangzhou, Guangdong, China

Site Status

Countries

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China

References

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Best KP, Gold M, Kennedy D, Martin J, Makrides M. Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials. Am J Clin Nutr. 2016 Jan;103(1):128-43. doi: 10.3945/ajcn.115.111104. Epub 2015 Dec 16.

Reference Type BACKGROUND
PMID: 26675770 (View on PubMed)

Anandan C, Nurmatov U, Sheikh A. Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis. Allergy. 2009 Jun;64(6):840-8. doi: 10.1111/j.1398-9995.2009.02042.x. Epub 2009 Apr 7.

Reference Type BACKGROUND
PMID: 19392990 (View on PubMed)

Wu WF, Wan KS, Wang SJ, Yang W, Liu WL. Prevalence, severity, and time trends of allergic conditions in 6-to-7-year-old schoolchildren in Taipei. J Investig Allergol Clin Immunol. 2011;21(7):556-62.

Reference Type BACKGROUND
PMID: 22312941 (View on PubMed)

Other Identifiers

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Weijia,Wu

Identifier Type: -

Identifier Source: org_study_id