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Genotype-related Molecular Targets in the Vitamin D Pathway for Spinal Disc Diseases

NCT ID: NCT03343899

Last Updated: 2017-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-02-17

Study Completion Date

2019-02-17

Brief Summary

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The objective of our study will be to analyze the interplay between particular VDR variants and its ligand in cells obtained from intervertebral disc and cartilage endplate and their action on cell proliferation and phenotype maintenance. The identification of novel molecular targets in the vitamin D pathway, potentially promoting pathological alterations of the tissues involved in spinal disc diseases, will allow to develop innovative and more personalized preventive and pharmacological/nutritional therapies.

Detailed Description

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Conditions

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Intervertebral Disk Degeneration

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

patients with spinal disc diseases

* males and females
* 18≤age ≤ 70 years old
* Italian white
* patients with spinal disc diseases that will be surgically treated

Exclusion Criteria

\- age \< 18 or \> 70 years old
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Alessandra Colombini

Milan, , Italy

Site Status RECRUITING

Countries

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Italy

Facility Contacts

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Alessandra Colombini

Role: primary

Other Identifiers

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GenVDisc

Identifier Type: -

Identifier Source: org_study_id