OCS Lung System EXPAND II Trial

NCT ID: NCT03343535

Last Updated: 2024-02-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

46 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-12

Study Completion Date

2022-07-06

Brief Summary

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To evaluate the safety and effectiveness of the OCS™ Lung System to recruit, preserve and assess non-ideal donor lungs that may not meet current standard donor lung acceptance criteria for transplantation.

Detailed Description

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Inclusion

At least one of the following:

* Donor PaO2/FiO2 ≤ 300 mmHg at the time of the offer; or
* Expected cross-clamp time \> 6 hours for the second lung; or
* Donor after Cardiac Death (DCD donor); or
* Donor age ≥ 55 years old

Conditions

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Lung Transplantation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

OCS Lung System
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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OCS Preservation

Group Type EXPERIMENTAL

OCS Lung Preservation

Intervention Type DEVICE

OCS Lung Preservation

Interventions

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OCS Lung Preservation

OCS Lung Preservation

Intervention Type DEVICE

Other Intervention Names

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OCS Lung Transplant

Eligibility Criteria

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Inclusion Criteria

* Male or female primary double lung transplant candidate
* Age ≥ 18 years old
* Signed: 1) written informed consent document and 2) authorization to use and disclose protected health information

Exclusion Criteria

* Prior solid organ or bone marrow transplant
* Single lung recipient
* Chronic use of hemodialysis or renal replacement therapy for diagnosis of chronic renal dysfunction requiring dialysis
* Participant in any other clinical or investigational trials/programs
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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TransMedics

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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St. Joseph's Hospital and Medical Center

Phoenix, Arizona, United States

Site Status

UCLA Medical Center

Los Angeles, California, United States

Site Status

University of California, San Francisco

San Francisco, California, United States

Site Status

Stanford University Medical Center

Stanford, California, United States

Site Status

The Johns Hopkins Hospital

Baltimore, Maryland, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

University of Minnesota

Minneapolis, Minnesota, United States

Site Status

University of Nebraska

Omaha, Nebraska, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Temple University Hospital

Philadelphia, Pennsylvania, United States

Site Status

Baylor St. Luke's Medical Center

Houston, Texas, United States

Site Status

Houston Methodist

Houston, Texas, United States

Site Status

University of Virginia

Charlottesville, Virginia, United States

Site Status

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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OCS-LUN-012017

Identifier Type: -

Identifier Source: org_study_id

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