Celebrex Premedication in Teeth With Symptomatic Irreversible Pulpitis
NCT ID: NCT03339544
Last Updated: 2017-11-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
46 participants
INTERVENTIONAL
2017-12-01
2019-12-31
Brief Summary
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Detailed Description
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Previous clinical trials have shown that the use of NSAIDS as a premedication prior to endodontic treatment was effective in reducing the pain and increasing the anesthetic success, since as high as 80% of the patients with pre-operative pain experience pain after endodontic treatment.
In this study, Celebrex (Celecoxib) 200mg will be given to the patients 1 hour before initiation of the treatment, and its effect on reducing the pain will be compared with a placebo.
Celebrex being a selective COX-2 inhibitor, it will spare the physiological tissue prostaglandin production while inhibiting the inflammatory prostaglandin production thus allow for effective analgesia with fewer side effects than Non-Selective NSAIDS (nsNSAIDS).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Celebrex premedication
Celebrex is a NSAID with selective COX-2 inhibition properties, is given as an intervention to assess the pain
Celebrex premedication
celebrex (celecoxib) 200mg is a non-steroidal anti-infalmmatory drug with selective COX-2 inhibition.
Placebo tablets
placebo tablets to compare the efficacy of Celebrex on the intra-operative and post-operative pain accompanying endodontic treatment of teeth with irreversible pulpits
Placebo
placebo is given as a tablet before initiation of endodontic treatment
Interventions
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Celebrex premedication
celebrex (celecoxib) 200mg is a non-steroidal anti-infalmmatory drug with selective COX-2 inhibition.
Placebo
placebo is given as a tablet before initiation of endodontic treatment
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patients able to understand Visual Analogue Scale and sign the informed conset
Mandibular molar teeth with:
* Preoperative sharp pain
* Vital pulp tissue
* Normal peripaical radiographic appearance or slight widening of the lamina dura
Exclusion Criteria
* Pregnant females
* Patients having significant systemic disorder
* Patients with psychological disturbances
* Patients with bruxism or clenching
Teeth that have:
* Associated with swelling or fistulous tract
* Acute or chronic periapical abscess
* Greater than grade I mobility
* Periodontitis
* No possible restorability
* previous endodontic treatment
20 Years
40 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Yousra Khaled Mohamed Ezzat
Resident at Endodontic department. Faculty of Oral and Dental Medicine
Central Contacts
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References
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Lee Y, Rodriguez C, Dionne RA. The role of COX-2 in acute pain and the use of selective COX-2 inhibitors for acute pain relief. Curr Pharm Des. 2005;11(14):1737-55. doi: 10.2174/1381612053764896.
Lapidus D, Goldberg J, Hobbs EH, Ram S, Clark GT, Enciso R. Effect of premedication to provide analgesia as a supplement to inferior alveolar nerve block in patients with irreversible pulpitis. J Am Dent Assoc. 2016 Jun;147(6):427-37. doi: 10.1016/j.adaj.2016.01.006. Epub 2016 Mar 4.
Other Identifiers
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celebrex premedication
Identifier Type: -
Identifier Source: org_study_id