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Effect of Weight Reduction on Immunity

NCT ID: NCT03336086

Last Updated: 2017-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

29 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-20

Study Completion Date

2012-12-25

Brief Summary

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This study included two groups of premenopausal healthy obese women. Experimental group underwent a weight loss program involved a low calorie diet plus anti-obesity drugs and moderate physical activity and control group underwent an ad libitum diet. At baseline and after a 10-15% weight loss lymphocyte subgroups were analyzed and compared between two group.

Detailed Description

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TCD3 and NKC CD16/56 were decreased significantly. Hence this weight loss program impaired viral immunity

Conditions

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Lymphocytes Weight Loss Viral Diseases Immunity Anti-obesity Agents

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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experimental

This group underwent a weight loss program

Group Type OTHER

weight loss program

Intervention Type COMBINATION_PRODUCT

A low calorie diet+ Orlistat+ Soluble Fiber+ Physical activity

control

This group underwent adlibitum diet + physical activity

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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weight loss program

A low calorie diet+ Orlistat+ Soluble Fiber+ Physical activity

Intervention Type COMBINATION_PRODUCT

Other Intervention Names

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experimental

Eligibility Criteria

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Inclusion Criteria

* BMI \>=30
* female
* healthy
* no smoking
* not lactating
* not pregnant
* no medication use

Exclusion Criteria

* pregnancy
* any disease
* any medication use
* iron and zinc deficiency
* any supplement use
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Mashhad University of Medical Sciences

OTHER

Sponsor Role collaborator

Shiraz University of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Mahsa Mehrdad

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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900413

Identifier Type: -

Identifier Source: org_study_id