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Stress Urinary Incontinence in Women With Multiple Sclerosis

NCT ID: NCT03332654

Last Updated: 2017-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

363 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-01

Study Completion Date

2016-03-31

Brief Summary

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Objective: To report the prevalence and risk factors of stress urinary incontinence (SUI) and the prevalence of intrinsic sphincter deficiency in women with multiple sclerosis (MS). Methods: A retrospective study was conducted among Female patients with MS, followed for lower urinary tract symptoms (LUTS) during a 15-year period. Demographic data, MS history, expanded disability status scale (EDSS) score at the urodynamic visit, obstetrical past, birth weight, LUTS, and urodynamic findings were collected. SUI was defined as incontinence during cough, or any effort. A maximum urethral closure pressure less than 30 cm H2O defined intrinsic sphincter deficiency. Results: In total 363 women with a mean age of 46.7±10.8 years and a mean disease duration of 12.9±8.7 years were included. The incidence of relapsing remitting MS, a secondary progressive form, and a primary progressive form was 60.6%, 32.8%, and 6.6%, respectively. The prevalence of SUI was 31.4%. The prevalence of intrinsic sphincter deficiency was 1.4% and 0.8% of these patients had a SUI (P=0.300). In a multivariate analysis, women with a SUI had significantly higher birth weight (P=0.030), a pelvic organ prolapse (P=0.021), urgent urinary incontinence (P=0.006), a lower EDSS score (P=0.019), and a weaker containing effort (P\<0.001). Conclusions: The prevalence of SUI in women with MS was 31.4%. This symptom could affect the quality of life of women with MS.

Detailed Description

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Conditions

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Urinary Incontinence, Stress Multiple Sclerosis

Keywords

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Urinary Incontinence, Stress Multiple Sclerosis Lower Urinary Tract Symptoms

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Multiple sclerosis

Prevalence and risk factor of stress urinary incontinence in women with multiple sclerosis and included in the database over 15 years from December 1999 to June 2014, who had undergone a urodynamic test

Determine prevalence of stress urinary incontinence

Intervention Type OTHER

Interventions

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Determine prevalence of stress urinary incontinence

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women aged \>18 years
* Multiple sclerosis
* Urodynamic test for lower urinary tract symptoms
* Followed in Saint Philibert Hospital between December 1999 to June 2014

Exclusion Criteria

* Non confirmation of diagnosis of Multiple sclerosis
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Lille Catholic University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Cecile Donzé, MD

Role: PRINCIPAL_INVESTIGATOR

GHICL

Other Identifiers

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OBS-019

Identifier Type: -

Identifier Source: org_study_id