Frequency Of Eye Problems In Type 2 Diabetes With Chronic Kidney Disease
NCT ID: NCT03330054
Last Updated: 2017-11-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2017-12-01
2018-06-01
Brief Summary
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Detailed Description
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Diabetes mellitus is the most common cause of chronic kidney disease in developed countries. In patients with diabetes, there is a steady advance from microalbuminuria to dipstick positive proteinuria and a progression to renal failure. (Davidson's.,2014) .The most commonly diagnosed diabetes-related complications is diabetic retinopathy. Its prevalence increases with the duration of diabetes. Some 20%of people with type 1 diabetes will have retinal changes after 10 years, rising to \>95% after20 years; 20-30% of people with type 2 diabetes have retinopathy at diagnosis.(Kumar \& Clark's ., 2016) .
Also from risk factors of diabetic retinopathy is nephropathy, and if severe, is associated with worsening of Diabetic retinopathy. Conversely, treatment of renal disease (e.g. renal transplantation) may be associated with improvement of retinopathy and a better response to photocoagulation.(Kanaski ,2016) The high burden of ocular disease in Chronic kidney disease can be explained, in part, by the sharing of risk factors common to both kidney and eye diseases such as age, smoking, hypertension, diabetes, raised serum cholesterol and obesity. Ocular diseases may also be directly linked to chronic kidney disease via common pathogenic pathways, including, atherosclerosis, microangiopathy, inflammation and oxidative stress (Wong et al., 2014).
In our study we seek to do the following for participants :
1. A detailed history including
1. Age, sex, smoking Habits
2. Duration of diabetes mellitus and treatment.
3. Chronic kidney disease stage by estimated glomerular filtration rate according to MDRD formula
4. Duration of haemodialysis.
5. Associated co-morbidity as hypertension,
6. Therapeutic history eg; angiotensin converting enzyme, angiotensin II receptor blocker, amiodarone, erythropoietin.
2. Complete Clinical examination including haemodynamics, complete cardiac, chest, abdominal, lower limb examination, cranial nerve examination.
3. Complete eye examination including detailed fundus examination, classifying expected eye problems as:
* Cataract. - Glaucoma
* Cranial nerve affection
* Retinopathy either proliferative, non proliferative or macular oedema.
4. The following investigations will be done:
* Serum creatinine \& Blood Urea for estimation of glomerular filtration rate
* Glycated haemoglobin (HbA1c).
* lipogram.
* Complete blood count
* ECG
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Group A
50 patients Type 2 Diabetes without renal impairment will be examined using fundoscope
fundoscope
Fundoscope for eye examination
Group B
25 patients Type 2 Diabetes with chronic kidney disease not on replacement therapy (stage I-IV) will be examined using fundoscope
fundoscope
Fundoscope for eye examination
Group C
25 patients Type 2 Diabetes with end stage renal disease on haemodialysis will be examined using fundoscope
fundoscope
Fundoscope for eye examination
Interventions
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fundoscope
Fundoscope for eye examination
Eligibility Criteria
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Inclusion Criteria
* 25 patients Type 2 Diabetes with chronic kidney disease not on replacement therapy. (stage I-IV)
* 25 patients Type 2 Diabetes with end-stage renal disease on haemodialysis
Exclusion Criteria
* Type 1 Diabetics .
* Acute kidney injury in Diabetics.
ALL
No
Sponsors
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Assiut University
OTHER
Mohammed Ramadan Abdallah
OTHER
Responsible Party
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Mohammed Ramadan Abdallah
Principal Investigator
Principal Investigators
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Lobna F El-Toony, MD
Role: STUDY_CHAIR
Assiut University
Central Contacts
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Other Identifiers
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AssiutU MRAbdallah
Identifier Type: -
Identifier Source: org_study_id