Immune Responses in Health Care Personnel

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-10-18

Study Completion Date

2027-10-14

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is an investigator-initiated 10 year long open cohort observational study, aiming to increase the understanding of the humoral and cellular immunological mechanisms of vaccination against influenza, including effects of repeated vaccination, the duration of protection, immunity against circulating viruses, as well as factors affecting the immunological responses and immunity against other vaccine preventable infectious diseases among health care personnel.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Study of Immune Responses to Influenza Vaccination

NCT03346772

Influenza Vaccination

RECRUITING PHASE4

Persistence of Immune Response After Vaccination With Influenza Vaccine

NCT01906190

Influenza, Human Immunisation Reaction

COMPLETED NA

Immune Response Following Seasonal Influenza Vaccination

NCT03163342

Influenza

COMPLETED PHASE4

Immune Response Study of Influenza Vaccine

NCT01310374

Influenza Vaccine Allergy Cell Mediated Reaction

COMPLETED

Does Repeat Influenza Vaccination Constrain Influenza Immune Responses and Protection

NCT05110911

Influenza, Human SARS-CoV-2 Infection

ACTIVE_NOT_RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Influenza vaccination is given according to the normal routine of Hospital District of Helsinki and Uusimaa (HUS) occupational health care. Blood samples will be collected before vaccination, 5 weeks after vaccination and 6 months after vaccination. Both the same participants and also new participants will be recruited each year. The analysis will be mainly descriptive.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Influenza

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Influenza vaccine recipients

Health care workers vaccinated by their occupational health care according to the routine praxis.

influenza vaccine

Intervention Type BIOLOGICAL

Vaccine for prevention of influenza. Vaccines change by influenza season.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

influenza vaccine

Vaccine for prevention of influenza. Vaccines change by influenza season.

Intervention Type BIOLOGICAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Members of health care or laboratory personnel in HUS having decided to take the seasonal influenza vaccination by the routine occupational health care service
* General good health as established by or volunteer's own statement
* Written informed consent
* Presumably able and willing to participate in the study during the starting influenza season

Exclusion Criteria

* Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection.
* Administration (longer than 14 days) of immunosuppressants or other immune- modifying drugs within 6 months before the vaccination; oral corticosteroids in dosages of 20 mg/day or more prednisolone or equivalent are excluded; inhaled or topical steroids are allowed.
* Pregnancy or lactation
* Acute disease at the time of enrolment (defined as the presence of a moderate or severe illness with or without fever)
* Contraindication for influenza vaccination
* Any other criteria which, in the investigator's or dedicated study staff member's opinion, would compromise the ability of a subject to participate in the study, a subject's well-being, or the outcome of the study

Minimum Eligible Age

18 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes