Study to Assess the Inhibition of Plaque Formation in Subjects With a Gingival Index ≤1.5

NCT ID: NCT03322124

Last Updated: 2019-01-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-01-22
• Study Completion Date: 2018-12-14

Brief Summary

The objective of the study is to demonstrate the superiority of 0.1% octenidine mouthwash (Octenidin Mundspüllösung, OML) to placebo (PLAC) in the inhibition of plaque formation. The study will consist of a 14-day screening period and a 5-day treatment period.

Conditions

Inhibition of Plaque Formation (by Gingivitis-Index ≤1.5)

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: QUADRUPLE

Study Groups

Octenidine Mouthwash

0.1% Octenidinedihydrochlorid Solution for oromucosal use, mouth rinse with 10 ml for 30 s, 10 applications over 5 days

Group Type: EXPERIMENTAL

Octenidinedihydrochlorid

Intervention Type: DRUG

Mouth rinsing of the oral cavity with Octenidinehydrochlorid vs.Placebo over a period of 5 days

Placebo

Placebo Solution for oromucosal use, mouth rinse with 10 ml for 30 s, 10 applications over 5 days

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: OTHER

Mouth rinsing of the oral cavity with Octenidinehydrochlorid vs.Placebo over a period of 5 days

Interventions

Octenidinedihydrochlorid

Mouth rinsing of the oral cavity with Octenidinehydrochlorid vs.Placebo over a period of 5 days

Intervention Type: DRUG

Placebo

Mouth rinsing of the oral cavity with Octenidinehydrochlorid vs.Placebo over a period of 5 days

Intervention Type: OTHER

Other Intervention Names

0.1% Octenidine Mouthwash; OML

Eligibility Criteria

Inclusion Criteria

1. Adult male and female subjects (aged 18 and older);

2. Subjects with a total mean gingival index1 (GI, Löe, 1967) ≤1.5 (0.0-1.5);

3. Subjects with at least 20 teeth (excluding wisdom teeth) with complete natural "Ramfjord-teeth" or their replacement teeth and 10 natural anterior teeth (excluding teeth provided with prosthetics such as crowns, dental bridges, veneers or large vestibular fillings such as large cervical or frontal teeth fillings; teeth with small interdental and orally oriented fillings are allowed);

4. Non-pigmented gingiva;

5. Signed informed consent.

Exclusion Criteria

1. Subjects with severe systemic diseases (e.g. hepatitis, human immunodeficiency virus [HIV] infection, tuberculosis, acute cancer treatment);

2. Subjects who require endocarditis prophylaxis for dental examination and treatment;

3. Subjects with caries requiring treatment (e.g. caries with cavity) or other oral diseases (including gingival hyperplasia, diseases of the oral mucosa);

4. Subjects who have a history of chronic or aggressive periodontitis;

5. Subjects with current moderate or severe chronic or aggressive periodontitis (periodontal screening index [PSI] >2 in more than 2 sextants or PSI >3);

6. Subjects showing a GI score of 3 on at least one tooth;

7. Subjects who underwent oral surgery within 14 days prior to Screening;

8. Subjects who used antiseptic mouth rinse within 14 days prior to Screening;

9. Subjects wearing orthodontic appliances and removable dentures (Wire-retainers after orthodontic treatment are allowed);

10. Subjects treated with antibiotics less than 3 months prior to the baseline examination at Visit 1 and/or planning such treatment for the duration of the study;

11. Subjects treated with systemically acting corticosteroids or corticosteroids applied via the oral cavity (e.g. asthma sprays);

12. Subjects who suffer from xerostomia;

13. Subjects who have a known hypersensitivity or allergy to the test product and its ingredients or to medications that have a similar chemical structure;

14. Participation of the subject in another clinical study within the last 4 weeks before enrolment in and during this study;

15. Incapability of assessing essence and possible consequences of the study (e.g. alcoholism);

16. Pregnant or breastfeeding women;

17. Women with childbearing potential except those who fulfill one of the following criteria:

1. Post-menopausal (12 months of natural amenorrhea or 6 months of amenorrhea with serum follicle-stimulating hormone [FSH] >40 U/ml);

2. Postoperative (6 weeks after bilateral ovariectomy with or without hysterectomy);

3. Continuous and correct application of a highly effective contraception method with a Pearl Index <1% (e.g. implants, depots, oral contraceptives, intrauterine device [IUD]);

4. Sexual abstinence; whereas sexual abstinence is considered a highly effective method only if defined as refraining from heterosexual intercourse during the entire period of risk associated with the study treatments. The reliability of sexual abstinence needs to be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the subject;

5. Confirmation of vasectomy of the sexual partner;

18. Evidence suggesting that the subject is not likely to follow the study protocol (e.g. lacking compliance).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Schülke & Mayr GmbH

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Katrin Lorenz, Dr.med.dent.

Role: PRINCIPAL_INVESTIGATOR

Med. Fakultät C. G. Carus der TU Dresden, Poliklinik für Parodontologie

Locations

Poliklinik für Parodontologie der Johann Wolfgang Goethe Universität Frankfurt am Main

Frankfurt am Main, Hesse, Germany

Poliklinik für Parodontologie der Med. Fakultät C. G. Carus der TU Dresden

Dresden, Saxony, Germany

Poliklinik für Zahnerhaltung und Parodontologie am Universitätsklinikum Leipzig

Leipzig, Saxony, Germany

Countries

Germany

Other Identifiers

2017-001697-42

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

OML-III-A

Identifier Type: -

Identifier Source: org_study_id