BOTOX® Intravesical Instillation in Participants With Overactive Bladder and Urinary Incontinence

NCT ID: NCT03320850

Last Updated: 2021-08-13

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

383 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-04

Study Completion Date

2020-07-21

Brief Summary

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This study will evaluate the efficacy and safety of BOTOX® intravesical instillation in participants with overactive bladder and urinary incontinence.

Detailed Description

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Conditions

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Urinary Incontinence Overactive Bladder With Urinary Incontinence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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100U cohort - BOTOX® plus Hydrogel admixture

100U BOTOX® (onabotulinumtoxinA) and Hydrogel admixture administered as a single intravesical instillation on Day 1

Group Type EXPERIMENTAL

OnabotulinumtoxinA and Hydrogel admixture

Intervention Type DRUG

BOTOX® (onabotulinumtoxinA) and Hydrogel admixture administered as a single intravesical instillation

100U cohort - Placebo plus Hydrogel admixture

Placebo and Hydrogel admixture administered as a single intravesical instillation on Day 1

Group Type PLACEBO_COMPARATOR

Placebo and Hydrogel admixture

Intervention Type DRUG

Placebo and Hydrogel admixture administered as a single intravesical instillation

300U cohort - BOTOX® plus Hydrogel admixture

300U BOTOX® (onabotulinumtoxinA) and Hydrogel admixture administered as a single intravesical instillation on Day 1

Group Type EXPERIMENTAL

OnabotulinumtoxinA and Hydrogel admixture

Intervention Type DRUG

BOTOX® (onabotulinumtoxinA) and Hydrogel admixture administered as a single intravesical instillation

300U cohort - Placebo plus Hydrogel admixture

Placebo and Hydrogel admixture administered as a single intravesical instillation on Day 1

Group Type PLACEBO_COMPARATOR

Placebo and Hydrogel admixture

Intervention Type DRUG

Placebo and Hydrogel admixture administered as a single intravesical instillation

400U cohort - BOTOX® plus Hydrogel admixture

400U BOTOX® (onabotulinumtoxinA) and Hydrogel admixture administered as a single intravesical instillation on Day 1

Group Type EXPERIMENTAL

OnabotulinumtoxinA and Hydrogel admixture

Intervention Type DRUG

BOTOX® (onabotulinumtoxinA) and Hydrogel admixture administered as a single intravesical instillation

400U cohort - Placebo plus Hydrogel admixture

Placebo and Hydrogel admixture administered as a single intravesical instillation on Day 1

Group Type PLACEBO_COMPARATOR

Placebo and Hydrogel admixture

Intervention Type DRUG

Placebo and Hydrogel admixture administered as a single intravesical instillation

500U cohort - BOTOX® plus Hydrogel admixture

500U BOTOX® (onabotulinumtoxinA) and Hydrogel admixture administered as a single intravesical instillation on Day 1

Group Type EXPERIMENTAL

OnabotulinumtoxinA and Hydrogel admixture

Intervention Type DRUG

BOTOX® (onabotulinumtoxinA) and Hydrogel admixture administered as a single intravesical instillation

500U cohort - Placebo plus Hydrogel admixture

Placebo and Hydrogel admixture administered as a single intravesical instillation on Day 1

Group Type PLACEBO_COMPARATOR

Placebo and Hydrogel admixture

Intervention Type DRUG

Placebo and Hydrogel admixture administered as a single intravesical instillation

Interventions

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OnabotulinumtoxinA and Hydrogel admixture

BOTOX® (onabotulinumtoxinA) and Hydrogel admixture administered as a single intravesical instillation

Intervention Type DRUG

Placebo and Hydrogel admixture

Placebo and Hydrogel admixture administered as a single intravesical instillation

Intervention Type DRUG

Other Intervention Names

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BOTOX® Botulinum Toxin Type A

Eligibility Criteria

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Inclusion Criteria

* Symptoms of OAB (frequency/urgency) with urinary incontinence for at least 6 months
* Inadequate response or limiting side effects with pharmacotherapy for the treatment of OAB

Exclusion Criteria

* Overactive Bladder caused by neurological condition
* Patient has predominance of stress incontinence
* History or evidence of pelvic or urological abnormality
* Prior use of BOTOX for any urological condition
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Allergan

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Till Geib

Role: STUDY_DIRECTOR

Allergan

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Coastal Clinical Research, Inc., an AMR company

Mobile, Alabama, United States

Site Status

Urological Assoc. of South AZ

Tucson, Arizona, United States

Site Status

Hope Clinical Research

Canoga Park, California, United States

Site Status

San Bernardino Urological Associates Medical Group

San Bernardino, California, United States

Site Status

Wr-McCr, Llc

San Diego, California, United States

Site Status

San Diego Clinical Trials

San Diego, California, United States

Site Status

Sutter Institute for Medical Health

Vacaville, California, United States

Site Status

West Coast Urology

Whittier, California, United States

Site Status

The Urology Center of Colorado

Denver, Colorado, United States

Site Status

Urology Associates, P.C

Englewood, Colorado, United States

Site Status

Adult and Pediatric Urology

Bridgeport, Connecticut, United States

Site Status

Women's Health Specialty Care

Farmington, Connecticut, United States

Site Status

CT Clinical Research Center/Urologist Specialist

Middlebury, Connecticut, United States

Site Status

Innovative Medical Research of South FL, Inc.

Aventura, Florida, United States

Site Status

South Florida Medical Research

Aventura, Florida, United States

Site Status

Manatee Medical Research Institute

Bradenton, Florida, United States

Site Status

Sunrise Medical Research

Lauderdale Lakes, Florida, United States

Site Status

Urological Research Network

Miramar, Florida, United States

Site Status

Florida Urology Partners

North Redington Beach, Florida, United States

Site Status

Renstar Medical Research

Ocala, Florida, United States

Site Status

Clinical Research Center of Florida

Pompano Beach, Florida, United States

Site Status

Pinellas Urology, Inc.

St. Petersburg, Florida, United States

Site Status

North Idaho Urology

Coeur d'Alene, Idaho, United States

Site Status

Idaho Urologic Institute

Meridian, Idaho, United States

Site Status

Comprehensive Urological Care

Lake Barrington, Illinois, United States

Site Status

Urogynecology Associates, PC

Carmel, Indiana, United States

Site Status

First Urology,PSC

Jeffersonville, Indiana, United States

Site Status

The Iowa Clinic

West Des Moines, Iowa, United States

Site Status

DelRicht Research, LLC

New Orleans, Louisiana, United States

Site Status

Regional Urology, LLC

Shreveport, Louisiana, United States

Site Status

Chesapeake Urology Associates

Hanover, Maryland, United States

Site Status

Chesapeake Urology

Owings Mills, Maryland, United States

Site Status

Bay State Clinical Trials, Inc.

Watertown, Massachusetts, United States

Site Status

Women's Health Care Specialists

Kalamazoo, Michigan, United States

Site Status

Michigan Institute of Urology

Troy, Michigan, United States

Site Status

Adult Pediatric Urology & Urogynecology

Omaha, Nebraska, United States

Site Status

Excel Clinical Research

Las Vegas, Nevada, United States

Site Status

Premier Urology Group

Edison, New Jersey, United States

Site Status

Delaware Valley Urology

Mount Laurel, New Jersey, United States

Site Status

Western New York Urology Associates

Cheektowaga, New York, United States

Site Status

AccuMed Research Associates

Garden City, New York, United States

Site Status

Urological Surgeons of Long Island

Garden City, New York, United States

Site Status

Manhattan Medical Research Practice PLLC

New York, New York, United States

Site Status

Urology Institute of Long Island

Plainview, New York, United States

Site Status

Associated Medical Professionals- Urology

Syracuse, New York, United States

Site Status

American Health Research

Charlotte, North Carolina, United States

Site Status

Carolina Institute for Clinical Research

Fayetteville, North Carolina, United States

Site Status

Associated Urologists of North Carolina

Raleigh, North Carolina, United States

Site Status

Lyndhurst Clinical Research

Winston-Salem, North Carolina, United States

Site Status

Clinical Research Solutions, LLC

Middleburg Heights, Ohio, United States

Site Status

The Center for Men's & Women's Urology

Gresham, Oregon, United States

Site Status

Urologic Consultants of SE PA

Bala-Cynwyd, Pennsylvania, United States

Site Status

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

Urology Clinics of North Texas

Dallas, Texas, United States

Site Status

Houston Metro Urology

Houston, Texas, United States

Site Status

Virginia Urology

Richmond, Virginia, United States

Site Status

Urology of Virginia

Virginia Beach, Virginia, United States

Site Status

Washington Urology and Urogynecology Associates

Kirkland, Washington, United States

Site Status

Multicare Allenmore Hospital

Tacoma, Washington, United States

Site Status

Aurora Research Institute

West Allis, Wisconsin, United States

Site Status

Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Site Status

Toronto Western Hospital

Toronto, Ontario, Canada

Site Status

Countries

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United States Canada

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Related Links

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http://AllerganClinicalTrials.com

Additional information on study locations near you may be found at AllerganClinicalTrials.com.

Other Identifiers

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1839-201-021

Identifier Type: -

Identifier Source: org_study_id

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