Immunogenicity and Safety Profile of Primary Dose of bOPV Bio Farma Given Simultaneously With Pentabio And IPV

NCT ID: NCT03310073

Last Updated: 2017-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

143 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-31

Study Completion Date

2017-03-31

Brief Summary

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This study is to assess protectivity following four doses of bOPV which given simultaneously with Pentabio® and 1 dose of IPV at the 4th visit

Detailed Description

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To describe serological response after four doses of bOPV with 1 dose of IPV. To describe the antibody status to polio 60 days after birth dose of bOPV To assess the safety of bOPV which given simultaneously with Pentabio® and 1 dose 1 dosde of IPV at the 4th visit

Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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bOPV (bivalent OPV Bio Farma)

bOPV one dose corresponds to 2 drops (0.1ml). The vaccine shall be given orally.

The subject received bOPV, Pentabio and IPV according to the study schedule.

Group Type EXPERIMENTAL

bOPV

Intervention Type BIOLOGICAL

Batch Number: 2042015

Pentabio

Intervention Type BIOLOGICAL

Batch number: 5050115 The vaccine shall be given intramuscularly.

IPV

Intervention Type BIOLOGICAL

The vaccine shall be given intramuscularly.

Interventions

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bOPV

Batch Number: 2042015

Intervention Type BIOLOGICAL

Pentabio

Batch number: 5050115 The vaccine shall be given intramuscularly.

Intervention Type BIOLOGICAL

IPV

The vaccine shall be given intramuscularly.

Intervention Type BIOLOGICAL

Other Intervention Names

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bivalent Oral Polio Vaccine DTP-HB-Hib Vaccine

Eligibility Criteria

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Inclusion Criteria

* Healthy, full term, newborns infants.
* Newborns residing within a relatively short and easily accessible distance (\<30 km) from the study clinic(s) and not planning to travel away during the entire study period.
* Infant born after 37 weeks of pregnancy
* Infant weighing 2.5 kg or more at birth (Birth weight \> 2.5 kg)
* Healthy newborns, with no history of asphyxia or meconium aspiration.
* Father, mother or legally acceptable representative properly informed about the study and having signed the informed consent form.
* Parents will commit themselves to comply with the indications of the investigator and with the schedule of the trial.
* Mother at least elementary school graduate

Exclusion Criteria

* Child concomitantly enrolled or scheduled to be enrolled in another trial
* Known history of congenital or acquired immunodeficiency (including HIV infection)
* Evolving moderate or severe illness, especially infectious diseases or fever (axillary temperature ≥ 37.5°C )
* Newborns requiring hospitalization at birth.
* Infant immunized with non-scheduled bOPV or IPV during trial
Minimum Eligible Age

1 Minute

Maximum Eligible Age

1 Day

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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PT Bio Farma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kusnandi Rusmil

Role: PRINCIPAL_INVESTIGATOR

Hasan Sadikin General Hospital

Locations

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Hasan Sadikin Hospital

Bandung, West Java, Indonesia

Site Status

Countries

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Indonesia

Other Identifiers

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bOPV 0416

Identifier Type: -

Identifier Source: org_study_id