A Case-control Study of Costa Rican Adults With Myocardial Infarction

NCT ID: NCT03308838

Last Updated: 2017-10-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

4547 participants

Study Classification

OBSERVATIONAL

Study Start Date

1994-08-01

Study Completion Date

2004-08-01

Brief Summary

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This observational case-control trial sought to identify and characterize different exposures associated with nonfatal acute myocardial infarction in Costa Rican adults. Exposures assessed included dietary variables and adipose tissue fatty acids.

Detailed Description

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Conditions

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Myocardial Infarction, Acute

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Cases

Cases consisted of Costa Rican adults who were diagnosed as survivors of a first acute myocardial infarction.

No interventions assigned to this group

Controls

Controls consisted of healthy individuals randomly identified from the underlying source population in Costa Rica and matched to each case by age, sex, and area of residence.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Cases were eligible if they met the World Health Organization criteria for MI

Exclusion Criteria

* Died during hospitalization
* Were 75 years or older on the day of their first MI
* Were physically or mentally unable to answer the questionnaire
* Had a previous hospital admission related to cardiovascular disease


* Ever had an MI
* Were physically or mentally unable to answer the questionnaire
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universidad de Costa Rica

OTHER

Sponsor Role collaborator

Harvard School of Public Health (HSPH)

OTHER

Sponsor Role collaborator

University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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Ana Baylin

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ana Baylin, MD, DrPH

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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University of Costa Rica

San Pedro, Provincia de San José, Costa Rica

Site Status

Countries

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Costa Rica

References

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El-Sohemy A, Baylin A, Spiegelman D, Ascherio A, Campos H. Dietary and adipose tissue gamma-tocopherol and risk of myocardial infarction. Epidemiology. 2002 Mar;13(2):216-23. doi: 10.1097/00001648-200203000-00018.

Reference Type RESULT
PMID: 11880764 (View on PubMed)

Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. Circulation. 2003 Apr 1;107(12):1586-91. doi: 10.1161/01.CIR.0000058165.81208.C6. Epub 2003 Mar 10.

Reference Type RESULT
PMID: 12668490 (View on PubMed)

Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. High 18:2 trans-fatty acids in adipose tissue are associated with increased risk of nonfatal acute myocardial infarction in costa rican adults. J Nutr. 2003 Apr;133(4):1186-91. doi: 10.1093/jn/133.4.1186.

Reference Type RESULT
PMID: 12672941 (View on PubMed)

Kabagambe EK, Baylin A, Campos H. Nonfatal acute myocardial infarction in Costa Rica: modifiable risk factors, population-attributable risks, and adherence to dietary guidelines. Circulation. 2007 Mar 6;115(9):1075-81. doi: 10.1161/CIRCULATIONAHA.106.643544.

Reference Type RESULT
PMID: 17339565 (View on PubMed)

Aslibekyan S, Campos H, Loucks EB, Linkletter CD, Ordovas JM, Baylin A. Development of a cardiovascular risk score for use in low- and middle-income countries. J Nutr. 2011 Jul;141(7):1375-80. doi: 10.3945/jn.110.133140. Epub 2011 May 11.

Reference Type RESULT
PMID: 21562240 (View on PubMed)

Wang D, Campos H, Baylin A. Red meat intake is positively associated with non-fatal acute myocardial infarction in the Costa Rica Heart Study. Br J Nutr. 2017 Aug;118(4):303-311. doi: 10.1017/S000711451700201X.

Reference Type RESULT
PMID: 28875869 (View on PubMed)

Other Identifiers

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HUM00037337

Identifier Type: -

Identifier Source: org_study_id