Determinants of Formate Concentrations

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1701 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-12-01

Study Completion Date

2013-11-26

Brief Summary

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Formate is an important metabolite, serving as a donor of one-carbon groups to the intracellular tetrahydrofolate pool. However, little is known of its circulating concentrations or of their determinants. This study seeks to define formate levels and their determinants in a young, healthy population.

Serum formate will be measured in 1701 subjects from the Trinity Student Study. The subjects, males and females, aged 18 to 28 years, were enrolled at Trinity College, Dublin. Formate levels will be compared with other one-carbon metabolites, vitamin status, potential formate precursors, genetic polymorphisms, and lifestyle factors.

Detailed Description

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Conditions

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Healthy

Keywords

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formate one-carbon metabolism

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Interventions

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No Intervention

Cross-sectional study requiring a single serum sample

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Trinity College Dublin students with Irish grandparents

Exclusion Criteria

* None

Minimum Eligible Age

18 Years

Maximum Eligible Age

28 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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John (Sean) Brosnan

Professor of Biochemistry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anne Molloy, Ph.D.

Role: STUDY_CHAIR

University of Dublin, Trinity College

References

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Brosnan JT, Mills JL, Ueland PM, Shane B, Fan R, Chiu CY, Pangilinan F, Brody LC, Brosnan ME, Pongnopparat T, Molloy AM. Lifestyle, metabolite, and genetic determinants of formate concentrations in a cross-sectional study in young, healthy adults. Am J Clin Nutr. 2018 Mar 1;107(3):345-354. doi: 10.1093/ajcn/nqx065.

Reference Type DERIVED

PMID: 29566195 (View on PubMed)

Other Identifiers

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12.190 HREA

Identifier Type: -

Identifier Source: org_study_id