Overall Diet Quality and Breast Cancer Risk

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

96959 participants

Study Classification

OBSERVATIONAL

Study Start Date

1995-10-31

Study Completion Date

2011-12-31

Brief Summary

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The purpose of this study was to examine the relationship between indices of overall diet quality and incident breast cancer risk in a large prospective cohort of women.

Detailed Description

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This study examined the role of overall diet quality on the risk of developing invasive breast cancer among 96,959 women in the California Teachers Study, in which 4,826 women were diagnosed with breast cancer during follow-up (1995-2011). Participants' dietary habits were recorded at baseline (1995) using a 103-item Block95 Food Frequency Questionnaire to allow for the assessment of overall diet quality. Specifically, diet quality was characterized by the Alternate Mediterranean Diet (aMED), Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approaches to Stop Hypertension (DASH), and Paleolithic Index scores. Associations between diet quality and the risk of developing breast cancer were examined using multivariate Cox proportional hazard regression models to provide hazard ratios and corresponding 95% confidence intervals.

Conditions

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Invasive Breast Cancer Incident Breast Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Participants with no history of cancer diagnosis prior to baseline.
* Participants with no history of myocardial infarction prior to baseline.
* Participants with no history of stroke prior to baseline.
* Participants with no history of diabetes prior to baseline.
* Participants who are not missing excessive dietary data.
* Participants with energy intake values at ≥1% and ≤99% of the population distribution.

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Responsible Party

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Vikram Haridass

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Bernstein L, Allen M, Anton-Culver H, Deapen D, Horn-Ross PL, Peel D, Pinder R, Reynolds P, Sullivan-Halley J, West D, Wright W, Ziogas A, Ross RK. High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States). Cancer Causes Control. 2002 Sep;13(7):625-35. doi: 10.1023/a:1019552126105.

Reference Type BACKGROUND

PMID: 12296510 (View on PubMed)

Other Identifiers

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1998-453

Identifier Type: -

Identifier Source: org_study_id