Study of the Effectiveness and Clinical Practice Use of Glecaprevir Plus Pibrentasvir in Patients With Chronic Hepatitis C Genotypes 1 to 6

NCT ID: NCT03303599

Last Updated: 2021-05-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2118 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-13

Study Completion Date

2020-01-24

Brief Summary

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The interferon- and ribavirin- (RBV) free combination regimen of glecaprevir plus pibrentasvir (GLE/PIB) for the treatment of genotypes 1 to 6 of chronic hepatitis C (CHC) viral infection has been shown to be safe and effective in randomized controlled clinical trials.

This observational study is an effectiveness research examining the regimen of GLE/PIB, used according to local label, under real world conditions in a clinical practice patient population.

Detailed Description

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Conditions

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Hepatitis C

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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HCV Genotypes 1, 2, 3, 4, 5, or 6 participants

Participants receiving combination therapy with the glecaprevir plus pibrentasvir (GLE/PIB) regimen according to standard of care, international guidelines and in line with the current local label.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Participants are treatment-naïve or treatment-experienced with pegylatedinterferon (pegIFN), or IFN, and/or ribavirin (RBV) and/or sofosbuvir (PRS) with confirmed chronic hepatitis C (CHC), genotypes 1, 2, 3, 4, 5, or 6, with or without compensated cirrhosis, receiving combination therapy with the all oral glecaprevir plus pibrentasvir (GLE/PIB) regimen according to standard of care, international guidelines and in line with the current local label.
* Participants may be enrolled up to 4 weeks after treatment initiation
* Participants must not be participating or intending to participate in a concurrent interventional therapeutic trial.

Exclusion Criteria

None.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Klinikum Klagenfurt am Woerthersee, Apotheke /ID# 169931

Klagenfurt, Carinthia, Austria

Site Status

University Hospital St. Polten /ID# 169918

Sankt Pölten, Lower Austria, Austria

Site Status

Medizinische Universität Graz /ID# 169932

Graz, Styria, Austria

Site Status

Landeskrankenhaus Hall /ID# 169930

Hall in Tirol, Tyrol, Austria

Site Status

KH der Elisabethinen Linz GmbH /ID# 169915

Linz, Upper Austria, Austria

Site Status

Landeskrankenhaus /ID# 169922

Innsbruck, , Austria

Site Status

Wilhelminenspital der Stadt Wien /ID# 169914

Vienna, , Austria

Site Status

Klinikum Wels - Grieskirchen /ID# 169916

Wels, , Austria

Site Status

Uza /Id# 170960

Edegem, Antwerpen, Belgium

Site Status

UCL Saint-Luc /ID# 170964

Woluwe-Saint-Lambert, Brussels Capital, Belgium

Site Status

Algemeen Stedelijk Ziekenhuis /ID# 170876

Aalst, Oost-Vlaanderen, Belgium

Site Status

UZ Gent /ID# 170922

Ghent, Oost-Vlaanderen, Belgium

Site Status

Universitair Ziekenhuis Leuven /ID# 170921

Leuven, Vlaams-Brabant, Belgium

Site Status

Centre Hospitalier de Wallonie Picarde /ID# 200822

Tournai, Wallonne, Region, Belgium

Site Status

Zna /Id# 170927

Antwerp, , Belgium

Site Status

CHU Saint-Pierre /ID# 170920

Brussels, , Belgium

Site Status

CHU Brugmann /ID# 170956

Brussels, , Belgium

Site Status

Hopital Erasme /ID# 170918

Brussels, , Belgium

Site Status

Z.O.L - Campus St. Jan /ID# 171058

Genk, , Belgium

Site Status

AZ Middelares Gent /ID# 170874

Ghent, , Belgium

Site Status

Jessa Ziekenhuis /ID# 170958

Hasselt, , Belgium

Site Status

AZ Groeninge /ID# 170931

Kortrijk, , Belgium

Site Status

Centre Hospitalier Universitaire du Sart Tilman CHU de Liege /ID# 170930

Liège, , Belgium

Site Status

CHC Liege /ID# 170926

Liège, , Belgium

Site Status

CHU Ambroise Pare /ID# 171107

Mons, , Belgium

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Clinique Edith Cavell /ID# 170932

Uccle, , Belgium

Site Status

CHU Dinant Godinne /ID# 170929

Yvoir, , Belgium

Site Status

CHR Orleans - Hopital de la Source /ID# 202360

Orléans, Centre-Val de Loire, France

Site Status

CH Georges Renon /ID# 202737

Niort, Deux-Sevres, France

Site Status

CHU de Besancon - Jean Minjoz /ID# 208502

Besançon, Doubs, France

Site Status

CHU Dupuytren /ID# 202514

Limoges, Franche-Comte, France

Site Status

Hopital Haut-Lévêque /ID# 202501

Pessac, Gironde, France

Site Status

Hopital Purpan /ID# 202357

Toulouse, Haute-Garonne, France

Site Status

Hopital Purpan /ID# 204201

Toulouse, Haute-Garonne, France

Site Status

CH Annecy Genevois Site Annecy /ID# 202804

Epagny Metz Tessy, Haute-Savoie, France

Site Status

CH Spécialisé Esquirol /ID# 204522

Limoges, Haute-Vienne, France

Site Status

Centre Hospitalier de Béziers /ID# 202948

Béziers, Herault, France

Site Status

Hopital Saint Eloi /ID# 202512

Montpellier, Herault, France

Site Status

Hopital Broussais /ID# 202677

St-Malo, Ille-et-Vilaine, France

Site Status

CHU NANCY - Hopital Brabois Adultes /ID# 202570

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France

Site Status

Hopital de la Timone /ID# 202792

Marseille, Provence-Alpes-Côte d'Azur Region, France

Site Status

Charles Nicolle CHU Rouen /ID# 203518

Rouen, Seine-Maritime, France

Site Status

Centre Hosp Intercommunal de Creteil /ID# 202566

Créteil, Val-de-Marne, France

Site Status

Cabinet medical /ID# 202794

Aix-en-Provence, , France

Site Status

CHU d'Angers /ID# 202500

Angers, , France

Site Status

Clinique du Tondu /ID# 207508

Bordeaux, , France

Site Status

Centre Endo Nord Isere /ID# 204181

Bourgoin, , France

Site Status

Hopital de la Cavale Blanche /ID# 202640

Brest, , France

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Hopital Antoine Beclere /ID# 202676

Clamart, , France

Site Status

CHU Estaing /ID# 202949

Clermont-Ferrand, , France

Site Status

Hopital Henri Mondor /ID# 202806

Créteil, , France

Site Status

Centre Hospitalier Universitaire de Grenoble - Hopital Michallon /ID# 202957

Grenoble, , France

Site Status

CH d'Hyeres /ID# 202515

Hyères, , France

Site Status

Dr. Cuissard, Le Port, FR /ID# 203487

Le Port, , France

Site Status

C.H. de Bretagne Sud /ID# 202362

Lorient, , France

Site Status

Hopital de la Croix Rousse /ID# 203071

Lyon, , France

Site Status

Hopital Edouard Herriot /ID# 203149

Lyon, , France

Site Status

Hopital Europeen /ID# 205073

Marseille, , France

Site Status

Hopital Saint Joseph /ID# 202519

Marseille, , France

Site Status

Cabinet Medical, Boyer Darrigr /ID# 202050

Nanterre, , France

Site Status

Hopital l'Archet 2 /ID# 205295

Nice, , France

Site Status

CHU Nimes /ID# 208200

Nîmes, , France

Site Status

Hopital Bichat-Claude Bernard /ID# 202513

Paris, , France

Site Status

Hopital Saint Antoine /ID# 202565

Paris, , France

Site Status

Hopital Pitie Salpetriere /ID# 202364

Paris, , France

Site Status

Centre Hospitalier PERPIGNAN /ID# 205762

Perpignan, , France

Site Status

Hopital Robert Debre /ID# 202953

Reims, , France

Site Status

Gastrodoc /Id# 206290

Saint-Jean-de-Védas, , France

Site Status

Institut Arnault Tzanck /ID# 202363

Saint-Laurent-du-Var, , France

Site Status

Cabinet Medical, Dr. Constant, /ID# 202361

Toulon, , France

Site Status

Clinique Amroise Pare /ID# 205064

Toulouse, , France

Site Status

Hopital Joseph Ducuing /ID# 205666

Toulouse, , France

Site Status

Ctre Hospitalier de Tourcoing /ID# 202358

Tourcoing, , France

Site Status

Ctre Hospitalier de Tourcoing /ID# 202805

Tourcoing, , France

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Hopital Paul Brousse /ID# 202623

Villejuif, , France

Site Status

Hopital Beaujon /ID# 202675

Clichy, Île-de-France Region, France

Site Status

General Hospital of Athens Laiko /ID# 206421

Athens, Attica, Greece

Site Status

General Oncological Hospital of Kifisia Oi Agioi Anargyroi /ID# 206419

Kifissia, Attica, Greece

Site Status

Tzaneio general hospital of Piraeus /ID# 208828

Piraeus, Attica, Greece

Site Status

Papageorgiou General Hospital Thessaloniki /ID# 207980

Nea Efkarpia, Thessaloniki, Greece

Site Status

Gen Univ Hosp Alexandroupolis /ID# 206416

Alexandroupoli, , Greece

Site Status

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 206414

Athens, , Greece

Site Status

General Hospital Nikaias-Piraeus St. Panteleimon /ID# 206420

Pireaus, , Greece

Site Status

Bioclinic Thessaloniki /ID# 207981

Thessaloniki, , Greece

Site Status

University Gen Hosp AHEPA /ID# 209961

Thessaloniki, , Greece

Site Status

Interbalkan Medical Center /ID# 206417

Thessaloniki, , Greece

Site Status

Soroka Medical Center /ID# 169321

Beersheba, Southern District, Israel

Site Status

HaEmek Medical Center /ID# 169318

Afula, , Israel

Site Status

Assaf Harofeh Medical Center /ID# 169370

Be’er Ya‘aqov, , Israel

Site Status

Maccabi Health Services /ID# 169372

GUSH DAN, , Israel

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Hillel Yaffe Medical Center /ID# 169368

Hadera, , Israel

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Rambam Medical Center /ID# 169316

Haifa, , Israel

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Bnai Zion Medical Center /ID# 169358

Haifa, , Israel

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Carmel Medical Center /ID# 169309

Haifa, , Israel

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Shaare Zedek Medical Center /ID# 169329

Jerusalem, , Israel

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Gastroenterology Institute, Division of Medicine /ID# 169360

Jerusalem, , Israel

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Meir Medical Center /ID# 169327

Kfar Saba, , Israel

Site Status

Galilee Medical Center /ID# 169325

Nahariya, , Israel

Site Status

Rabin Medical Center /ID# 169320

Petah Tikva, , Israel

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Sheba Medical Center /ID# 169365

Ramat Gan, , Israel

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Tel Aviv Medical Center /ID# 169313

Tel Aviv, , Israel

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AOU Federico II /ID# 168131

Naples, Campania, Italy

Site Status

Ospedale Sant Orsola Malpighi /ID# 168127

Bologna, Emilia-Romagna, Italy

Site Status

Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 168711

Modena, Emilia-Romagna, Italy

Site Status

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 168137

Milan, Lombardy, Italy

Site Status

ASST Grande Ospedale Metropolitano Niguarda /ID# 168138

Milan, Lombardy, Italy

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ASST Grande Ospedale Metropolitano Niguarda /ID# 168712

Milan, Lombardy, Italy

Site Status

IBD Center - IRCCS Istituto Clinico Humanitas /ID# 169353

Rozzano, Milano, Italy

Site Status

AOU Citta della Salute Scienza /ID# 168142

Turin, Piedmont, Italy

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Fondazione PTV Policlinico Tor Vergata /ID# 168709

Rome, Roma, Italy

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Università Cattolica Sacro Cuore /ID# 168781

Rome, Roma, Italy

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Policlinico Paolo Giaccone /Id# 168134

Palermo, Sicily, Italy

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Azienda Universitaria Ospedali /ID# 168129

Bari, , Italy

Site Status

AOU di Cagliari - Presidio di /ID# 168132

Cagliari, , Italy

Site Status

A.O.U Sant'Anna di Ferrara /ID# 168714

Ferrara, , Italy

Site Status

AOU Riuniti di Foggia /ID# 168143

Foggia, , Italy

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Ospedale SM Goretti /ID# 169257

Latina, , Italy

Site Status

A.O.U. Policlinico G. Martino /ID# 168139

Messina, , Italy

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Ospedale S. Carlo Borromeo /ID# 168144

Milan, , Italy

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Azienda Ospedaliera Luigi Sacc /ID# 168136

Milan, , Italy

Site Status

Azienda Ospedaliera Luigi Sacc /ID# 168140

Milan, , Italy

Site Status

Azienda Ospedaliera di Rilievo /ID# 168141

Naples, , Italy

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AO Domenico Cutugno /ID# 168133

Napoli, , Italy

Site Status

Universita degli Studi della /ID# 168135

Napoli, , Italy

Site Status

Azienda Ospedaliera Maggiore d /ID# 168710

Novara, , Italy

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Azienda Ospedaliera di Padova /ID# 168125

Padua, , Italy

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Azienda Ospedaliera di Padova /ID# 168126

Padua, , Italy

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Azienda Ospedaliero - Universi /ID# 168130

Pisa, , Italy

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IRCCS Lazzaro Spallanzani /ID# 169234

Rome, , Italy

Site Status

AOU OO. RR. San Giovanni di Di /ID# 168715

Salerno, , Italy

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Krakowski Szpital Specjalistyczny im. Jana Pawla II /ID# 208451

Krakow, Lesser Poland Voivodeship, Poland

Site Status

Specjalistyczny Szpital im. dra Alfreda Sokolowskiego /ID# 208862

Wałbrzych, Lower Silesian Voivodeship, Poland

Site Status

NZOZ - Lubuska Specjalistyczna Poradnia Chorób Wątroby Sp. z o.o. /ID# 208449

Zielona GORA, Lower Silesian Voivodeship, Poland

Site Status

Szpital Wojewodzki w Opolu /ID# 208444

Opole, Opole Voivodeship, Poland

Site Status

Uniwersytecki Szpital Kliniczny w Bialymstoku /ID# 208604

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Szpital Specjalistyczny W Chorzowie /Id# 209129

Chorzów, Silesian Voivodeship, Poland

Site Status

NZOZ All-Medicus /ID# 208452

Katowice, Silesian Voivodeship, Poland

Site Status

ID Clinic /ID# 208332

Mysłowice, Silesian Voivodeship, Poland

Site Status

Wojewodzki Szpital Obserwacyjn /ID# 209345

Bydgoszcz, , Poland

Site Status

Wojewódzki Szpital Zespolony w Kielcach /ID# 210569

Kielce, , Poland

Site Status

Wojewodzki Szpit Bieganskiego /ID# 208445

Lodz, , Poland

Site Status

Wojewodzki Szpit Bieganskiego /ID# 209608

Lodz, , Poland

Site Status

MED-FIX Centrum Medyczne Sp. z /ID# 208453

Warsaw, , Poland

Site Status

NZOZ Przychodnia Specjalistycz /ID# 208334

Żychlin, Łódź Voivodeship, Poland

Site Status

Centro Hospitalar Barreiro Montijo, EPE /ID# 211267

Barreiro, Lisbon District, Portugal

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Centro Hospitalar Vila Nova Gaia/Espinho, EPE /ID# 208195

Vila Nova de Gaia, Porto District, Portugal

Site Status

Hospital Garcia de Orta, E.P.E /ID# 207717

Almada, Setúbal District, Portugal

Site Status

Centro Hospitalar Universitário Lisboa Central, EPE - Hospital Curry Cabral /ID# 208463

Lisbon, , Portugal

Site Status

Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 207910

Lisbon, , Portugal

Site Status

Centro Hospitalar do Porto EPE /ID# 207733

Porto, , Portugal

Site Status

Hopitaux Universitaires de Geneve /ID# 203435

Geneva, Canton of Geneva, Switzerland

Site Status

Kantonsspital St. Gallen /ID# 201025

Sankt Gallen, Canton of St. Gallen, Switzerland

Site Status

Inselspital, Universitaetsklinik /ID# 201022

Bern, , Switzerland

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Fondazione Epatocentro Ticino /ID# 201024

Lugano, , Switzerland

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Hopital Neuchatelois /ID# 201026

Neuchâtel, , Switzerland

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Universitaetsspital Zuerich /ID# 201023

Zurich, , Switzerland

Site Status

Countries

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Austria Belgium France Greece Israel Italy Poland Portugal Switzerland

References

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Vera J, Gomes A, Povoas D, Seixas D, Maltez F, Pedroto I, Maia L, Mota M, Vieira MJ, Manata MJ, Ferreira P, Lino S, Pereira Guedes T, Barradas V, Marques N. Real-World Effectiveness and Safety of Glecaprevir/Pibrentasvir for the Treatment of Chronic Hepatitis C: A Prospective Cohort Study in Portugal. Acta Med Port. 2024 May 2;37(5):323-333. doi: 10.20344/amp.19178. Epub 2024 Feb 7.

Reference Type DERIVED
PMID: 38325411 (View on PubMed)

Aghemo A, Horsmans Y, Bourgeois S, Bondin M, Gschwantler M, Hofer H, Semmo N, Negro F, Zhang Z, Marcinak J, Veitsman E, Hazzan R, Mimidis K, Goulis I, Marques N, Flisiak R, Mazur W, Roncero C, Marra F, Pageaux GP, Asselah T, Lampertico P. Real-World Outcomes in Historically Underserved Patients with Chronic Hepatitis C Infection Treated with Glecaprevir/Pibrentasvir. Infect Dis Ther. 2021 Dec;10(4):2203-2222. doi: 10.1007/s40121-021-00455-1. Epub 2021 Jun 14.

Reference Type DERIVED
PMID: 34125405 (View on PubMed)

Mullhaupt B, Semela D, Ruckstuhl L, Magenta L, Clerc O, Torgler R, Negro F, Semmo N. Real-world effectiveness and safety of glecaprevir/pibrentasvir therapy in patients with chronic hepatitis C virus infection in Switzerland. Swiss Med Wkly. 2021 Jan 19;151:w20399. doi: 10.4414/smw.2021.20399. eCollection 2021 Jan 18.

Reference Type DERIVED
PMID: 33516161 (View on PubMed)

Related Links

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Other Identifiers

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P17-094

Identifier Type: -

Identifier Source: org_study_id

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