Dolcanatide in Preventing Colorectal Cancer in Healthy Volunteers

NCT ID: NCT03300570

Last Updated: 2021-06-14

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 27 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-07-27
• Study Completion Date: 2021-05-17

Brief Summary

This phase I trial studies how well dolcanatide works in preventing colorectal cancer in healthy participants. Dolcanatide is similar to a natural hormone released into the intestine. It is thought that people who have low levels of the hormone are more likely to get colon cancer. It may be possible to prevent colon cancer by giving a drug that is similar to the hormone, such as dolcanatide.

Detailed Description

PRIMARY OBJECTIVES:

I. To identify the ability of dolcanatide (SP333), when administered as a single daily dose of 27 mg x 7 days, to induce a direct pharmacological effect on cGMP levels, based on biopsy samples from the rectum obtained pre- and post-intervention, as compared to placebo.

SECONDARY OBJECTIVES:

I. To assess the pharmacodynamic (PD) response rate between arms (dolcanatide versus placebo).

II. To confirm the safety and tolerability of dolcanatide, as compared to placebo.

OUTLINE: Participants are randomized to 1 of 2 arms.

ARM A: Participants receive dolcanatide orally (PO) once daily (QD) for 7 days.

ARM B: Participants receive placebo PO QD for 7 days.

After completion of study, participants are followed up at 21 and 51 days.

Conditions

Colorectal Carcinoma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Study Groups

Arm A (dolcanatide)

Participants receive dolcanatide PO QD for 7 days.

Group Type: EXPERIMENTAL

Dolcanatide

Intervention Type: DRUG

Given PO

Laboratory Biomarker Analysis

Intervention Type: OTHER

Correlative studies

Questionnaire Administration

Intervention Type: OTHER

Ancillary studies

Arm B (placebo)

Participants receive placebo PO QD for 7 days.

Group Type: PLACEBO_COMPARATOR

Laboratory Biomarker Analysis

Intervention Type: OTHER

Correlative studies

Placebo Administration

Intervention Type: OTHER

Given PO

Questionnaire Administration

Intervention Type: OTHER

Ancillary studies

Interventions

Dolcanatide

Given PO

Intervention Type: DRUG

Laboratory Biomarker Analysis

Correlative studies

Intervention Type: OTHER

Placebo Administration

Given PO

Intervention Type: OTHER

Questionnaire Administration

Ancillary studies

Intervention Type: OTHER

Other Intervention Names

SP 333; SP-333; SP333

Eligibility Criteria

Inclusion Criteria

• PRE-REGISTRATION INCLUSION
• Able to understand and willingness to sign a written informed consent document and follow study procedures
• Willing to abstain from grapefruit juice during study
• Willing to employ adequate contraception for men and women of childbearing potential; Note: acceptable methods include double barrier methods, intrauterine device (IUD), postmenopausal status documented by serum follicle stimulating hormone (FSH), and/or documentation of surgical sterilization
• Willing to provide blood and tissue specimens for research purposes
• REGISTRATION INCLUSION
• Normal organ function and have normal laboratory findings without clinically significant findings
• Leukocytes >= 3 x 10^3/microliter (B/L)
• Absolute neutrophil count >= 1.5 x 10^3/microliter (B/L)
• Platelets >= 100 x 10^3/microliter (B/L)
• Total bilirubin within normal institutional limits
• Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/ alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 1.5 x institutional upper limit of normal (ULN)
• Creatinine =< institutional upper limit of normal
• Body mass index < 35 kg/m^2
• No findings in the rectum of advanced adenoma, chronic inflammation, or cancer

Exclusion Criteria

• PRE-REGISTRATION EXCLUSION
• Documented history of advanced adenomas (>= 1 cm in maximal diameter, >= 3 in total number, villous morphology, or high-grade dysplasia) or colorectal cancer
• Family history of polyposis syndrome (e.g., familial adenomatous polyposis [FAP], hereditary nonpolyposis colorectal cancer [HNPCC]) or colorectal cancer (first degree relatives younger than 60 years old)
• History of gastroparesis
• History of surgery involving the luminal gastrointestinal (GI) tract, including bariatric surgery; exception: prior appendectomy >= 60 days prior to pre-registration is not an exclusion criterion
• History of celiac disease
• Inflammatory bowel disease (Crohn's disease, ulcerative colitis)
• Previous diagnosis of irritable bowel syndrome, chronic constipation, functional bowel disorders, colonic motility disorder, or opioid-induced constipation
• Any malignancy within 3 years of baseline; exception: participants with a history of basal cell or squamous cell skin cancer may be enrolled at the discretion of the investigator
• Currently receiving any other investigational agents
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to dolcanatide or to any of the excipients
• History of difficulty with sigmoidoscopy or abnormal colorectal anatomy
• Uncontrolled current illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• Pregnant or lactating women
• Current use of laxatives more than 3 times per week
• Current use of >= 5 cigarettes/day
• Current use of >= 3 alcoholic drinks/day
• Use of anti-coagulants or anti-platelet agents within 5 days prior to anticipated sigmoidoscopy; exception: individuals taking aspirin will not be excluded and will not be subject to a wash-out period
• History of bleeding/coagulation problems
• Any medical condition reported by the participant or documented in the medical record that is judged by the investigator to constitute a risk to safe participation
• Known or suspected mechanical gastrointestinal obstruction
• REGISTRATION EXCLUSION
• Sigmoidoscopy finding requiring clinical intervention
• Use of any illicit or illegal substances detected by urinary drug screen

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

David S Weinberg

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

NCI-2017-01783

Identifier Type: REGISTRY

Identifier Source: secondary_id

N01-CN-2012-00042

Identifier Type: -

Identifier Source: secondary_id

MAY2017-09-01

Identifier Type: OTHER

Identifier Source: secondary_id

MAY2017-09-01

Identifier Type: OTHER

Identifier Source: secondary_id

N01CN00042

Identifier Type: NIH

Identifier Source: secondary_id

View Link

P30CA015083

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NCI-2017-01783

Identifier Type: -

Identifier Source: org_study_id