Study the Effect of Probiotics Combined With Bismuth Quadruple Rescue Therapy on H Pylori Infective Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-12-31

Study Completion Date

2018-09-30

Brief Summary

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Retrospectivly follow-up the outpatients for H pylori eradication failures more than 2 times in the digestive department of Changhai hospital from 2015-2017,analyse the eradication rates and adverse effects of the therapy with 2w's compound lactobacillus acidophilus followed by 10d's bismuth, furazolidone, tetracycline contained quadruple scheme.

Detailed Description

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H pylori infection rate has been up to half of the world population. H pylori infection is associated with various diseases, especially gastric cancer.

With the increasingly resistant to antibiotics,the eradication rate has decreased a lot with traditional triple therapy. Exploring a valid scheem for patients who have failed multiple times is important.

Probiotics can improve gastrointestinal microenvironment, then release the adverse effects during the eradication process.Additionally,there is also a lot evidence that probiotics can inhibit H plori，but still controversially.

There is a low resistant rate about furazolidone and tetracycline. In this study investigators observe the efficacy of the therapy 2w's compound lactobacillus acidophilus followed by 10d's bismuth, furazolidone, tetracycline contained quadruple scheme on patients who have failed more than 2 times. 4 to 6 weeks after the therapy, if Urea Breath Test (UBT) is nedative which means eradicating H plori successfully.

Conditions

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Helicobacter Pylori Infection

Keywords

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Helicobacter Pylori eradication

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* H pylori eradication had failed more than 2 times
* Patients had never used furazolone and tetracycline
* The age varied from 18 to 80 years old

Exclusion Criteria

* H pylori initial eradication or had failed only 1 time
* The age was lower than 18,or higher than 80 years old
* Patients who had serious heart pulmonary disease ,live renal disease, or any cancers
* Pregnant women

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Zhaoshen Li

director of the Digestive Department

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Zhao S Li, MD

Role: PRINCIPAL_INVESTIGATOR

Central Contacts

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Yi Q Du, MD

Role: CONTACT

Phone: +86-13801993592

Email: [email protected]

Ai R Liu, MM