Trial Outcomes & Findings for Clinical Effects of Exercise Program Added to Pulmonary Rehabilitation in Patients With Cystic Fibrosis (NCT NCT03295201)

Results Overview

Modified Shuttle Test (MST) is used to measure the exercise tolerance. The patient is asked to walk until feeling tired between two fixed objects with a 10-meter interval, starting at normal walking speed and increasing the speed at the beginning of each minute. Maximum distance (meters) is measured for the test.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

22 participants

Primary outcome timeframe

Before treatment

Results posted on

2018-10-26

Participant Flow

Recruitment period was March 2017-October 2017 Setting: A university hospital outpatient clinics

Number of patients assessed for eligibility was 30. Among them,8 participants were excluded due to being inappropiate for the inclusion criteria (6 were out of age limits, 2 did not agree to participate in the study)

Participant milestones

Participant milestones
Measure	Pulmonary Rehabilitation+Exercise Group Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Overall Study STARTED	11	11
Overall Study COMPLETED	10	9
Overall Study NOT COMPLETED	1	2

Reasons for withdrawal

Reasons for withdrawal
Measure	Pulmonary Rehabilitation+Exercise Group Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Overall Study Lost to Follow-up	1	1
Overall Study Hospital admission	0	1

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.	Total n=19 Participants Total of all reporting groups
Age, Continuous	9 years STANDARD_DEVIATION 2 • n=10 Participants	10 years STANDARD_DEVIATION 3 • n=9 Participants	9 years STANDARD_DEVIATION 2 • n=19 Participants
Sex: Female, Male Female	3 Participants n=10 Participants	4 Participants n=9 Participants	7 Participants n=19 Participants
Sex: Female, Male Male	7 Participants n=10 Participants	5 Participants n=9 Participants	12 Participants n=19 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.
Region of Enrollment Turkey	10 participants n=10 Participants	9 participants n=9 Participants	19 participants n=19 Participants
Body Mass Index	16 kg/m^2 STANDARD_DEVIATION 2 • n=10 Participants	16 kg/m^2 STANDARD_DEVIATION 2 • n=9 Participants	16 kg/m^2 STANDARD_DEVIATION 2 • n=19 Participants

PRIMARY outcome

Timeframe: Before treatment

Modified Shuttle Test (MST) is used to measure the exercise tolerance. The patient is asked to walk until feeling tired between two fixed objects with a 10-meter interval, starting at normal walking speed and increasing the speed at the beginning of each minute. Maximum distance (meters) is measured for the test.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Exercise Tolerance	817 meters Standard Error 234.62	792.22 meters Standard Error 327.21

PRIMARY outcome

Timeframe: 6 weeks

Modified Shuttle Test (MST) is used to measure the exercise tolerance. The patient is asked to walk until feeling tired between two fixed objects with a 10-meter interval, starting at normal walking speed and increasing the speed at the beginning of each minute. Maximum distance (meters) is measured for the test.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Exercise Tolerance	980 meters Standard Error 277.24	1058.77 meters Standard Error 594.67

PRIMARY outcome

Timeframe: 3 months

Modified Shuttle Test (MST) is used to measure the exercise tolerance. The patient is asked to walk until feeling tired between two fixed objects with a 10-meter interval, starting at normal walking speed and increasing the speed at the beginning of each minute. Maximum distance (meters) is measured for the test.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Exercise Tolerance	1104 meters Standard Error 306.73	1036.66 meters Standard Error 457.16

PRIMARY outcome

Timeframe: 6 months

Modified Shuttle Test (MST) is used to measure the exercise tolerance. The patient is asked to walk until feeling tired between two fixed objects with a 10-meter interval, starting at normal walking speed and increasing the speed at the beginning of each minute. Maximum distance (meters) is measured for the test.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Exercise Tolerance	1251 meters Standard Error 324.15	1161.11 meters Standard Error 594.06

SECONDARY outcome

Timeframe: Before treatment

The Cystic Fibrosis Questionnaire-Revised (CFQR) is used to measure the quality of life. This scale is found to be valid and reliable in Turkish. The child version of this test consists 35 questions about physical function, emotional function, social function, body appearance, eating disorders, treatment difficulties, respiratory and digestive symptoms. The total score is calculated between 0-100 and higher scores define the better condition.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Quality of Life	86.4 units on a scale Standard Error 5.75	92.77 units on a scale Standard Error 9.94

SECONDARY outcome

Timeframe: 6 weeks

The Cystic Fibrosis Questionnaire-Revised (CFQR) is used to measure the quality of life. This scale is found to be valid and reliable in Turkish. The child version of this test consists 35 questions about physical function, emotional function, social function, body appearance, eating disorders, treatment difficulties, respiratory and digestive symptoms. The total score is calculated between 0-100 and higher scores define the better condition.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Quality of Life	88.9 units on a scale Standard Error 7.04	90.88 units on a scale Standard Error 13.37

SECONDARY outcome

Timeframe: 3 months

The Cystic Fibrosis Questionnaire-Revised (CFQR) is used to measure the quality of life. This scale is found to be valid and reliable in Turkish. The child version of this test consists 35 questions about physical function, emotional function, social function, body appearance, eating disorders, treatment difficulties, respiratory and digestive symptoms. The total score is calculated between 0-100 and higher scores define the better condition.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Quality of Life	87.2 units on a scale Standard Error 5.57	93.33 units on a scale Standard Error 11.35

SECONDARY outcome

Timeframe: 6 months

The Cystic Fibrosis Questionnaire-Revised (CFQR) is used to measure the quality of life. This scale is found to be valid and reliable in Turkish. The child version of this test consists 35 questions about physical function, emotional function, social function, body appearance, eating disorders, treatment difficulties, respiratory and digestive symptoms. The total score is calculated between 0-100 and higher scores define the better condition.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Quality of Life	89.7 units on a scale Standard Error 7.84	95.55 units on a scale Standard Error 12.64

SECONDARY outcome

Timeframe: Before treatment

The Balance Master Device- Limits of Stability Test (LOS) is used for to measure the postural stability of children. The LOS consists a 18x60 inch of a pressure platform which connected to a computer system. The patient is asked to stand on the platform barefoot and watch the image which can be moved by trunk movement on the computer the monitor. It is required to move the image towards to target points on the monitor with commands. Reaction time, movement velocity, endpoint excursion, maximum excursion and direction control parameters are calculated during these trunk movements. Reaction time (seconds) parameter is preferred to use for this study.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Postural Stability	1.29 seconds Standard Error 0.85	1.03 seconds Standard Error 0.53

SECONDARY outcome

Timeframe: 6 weeks

The Balance Master Device- Limits of Stability Test (LOS) is used for to measure the postural stability of children. The LOS consists a 18x60 inch of a pressure platform which connected to a computer system. The patient is asked to stand on the platform barefoot and watch the image which can be moved by trunk movement on the computer the monitor. It is required to move the image towards to target points on the monitor with commands. Reaction time, movement velocity, endpoint excursion, maximum excursion and direction control parameters are calculated during these trunk movements. Reaction time (seconds) parameter is preferred to use for this study.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Postural Stability	0.91 seconds Standard Error 0.66	0.83 seconds Standard Error 0.65

SECONDARY outcome

Timeframe: 3 months

The Balance Master Device- Limits of Stability Test (LOS) is used for to measure the postural stability of children. The LOS consists a 18x60 inch of a pressure platform which connected to a computer system. The patient is asked to stand on the platform barefoot and watch the image which can be moved by trunk movement on the computer the monitor. It is required to move the image towards to target points on the monitor with commands. Reaction time, movement velocity, endpoint excursion, maximum excursion and direction control parameters are calculated during these trunk movements. Reaction time (seconds) parameter is preferred to use for this study.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Postural Stability	0.88 seconds Standard Error 0.72	0.65 seconds Standard Error 0.52

SECONDARY outcome

Timeframe: 6 months

The Balance Master Device- Limits of Stability Test (LOS) is used for to measure the postural stability of children. The LOS consists a 18x60 inch of a pressure platform which connected to a computer system. The patient is asked to stand on the platform barefoot and watch the image which can be moved by trunk movement on the computer the monitor. It is required to move the image towards to target points on the monitor with commands. Reaction time, movement velocity, endpoint excursion, maximum excursion and direction control parameters are calculated during these trunk movements. Reaction time (seconds) parameter is preferred to use for this study.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Postural Stability	1.15 seconds Standard Error 0.69	0.92 seconds Standard Error 0.46

SECONDARY outcome

Timeframe: Before treatment

Forced expiratory volume in 1 second (FEV1)

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Pulmonary Function	82.8 millilitres Standard Deviation 14.57	83.78 millilitres Standard Deviation 21.06

SECONDARY outcome

Timeframe: 6 weeks

Forced expiratory volume in 1 second (FEV1)

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Pulmonary Function	93.3 millilitres Standard Deviation 21.71	82.11 millilitres Standard Deviation 17.14

SECONDARY outcome

Timeframe: 3 months

Forced expiratory volume in 1 second (FEV1)

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Pulmonary Function	86.6 millilitres Standard Deviation 12.19	82.77 millilitres Standard Deviation 17.85

SECONDARY outcome

Timeframe: 6 months

Forced expiratory volume in 1 second (FEV1)

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Pulmonary Function	87.7 millilitres Standard Deviation 16.95	90 millilitres Standard Deviation 23.52

SECONDARY outcome

Timeframe: Before treatment

The Cobb angle was measured on anteroposterior scoliosis graphs by the angle between the superior end plate of the vertebra corpus where the curve begins and the end plate of the vertebra corpus which the curve ends.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Spinal Deformity- The Cobb Angle (Researcher 1)	2.37 degrees Standard Deviation 1.40	7.75 degrees Standard Deviation 5.95

SECONDARY outcome

Timeframe: Before treatment

The Cobb angle was measured on anteroposterior scoliosis graphs by the angle between the superior end plate of the vertebra corpus where the curve begins and the end plate of the vertebra corpus which the curve ends.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Spinal Deformity- The Cobb Angle (Researcher 2)	2.12 degrees Standard Deviation 2.1	7.75 degrees Standard Deviation 5.12

SECONDARY outcome

Timeframe: 6 months

The Cobb angle was measured on anteroposterior scoliosis graphs by the angle between the superior end plate of the vertebra corpus where the curve begins and the end plate of the vertebra corpus which the curve ends.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Spinal Deformity- The Cobb Angle (Researcher 1)	3.5 degrees Standard Deviation 2.56	5.25 degrees Standard Deviation 3.41

SECONDARY outcome

Timeframe: 6 months

The Cobb angle was measured on anteroposterior scoliosis graphs by the angle between the superior end plate of the vertebra corpus where the curve begins and the end plate of the vertebra corpus which the curve ends.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Spinal Deformity- The Cobb Angle (Researcher 2)	3.88 degrees Standard Deviation 2.42	5.5 degrees Standard Deviation 2.83

SECONDARY outcome

Timeframe: Before treatment

The Modified Cobb angle was found on lateral scoliosis graphs by the angle between the superior end plate of the T4 vertebra corpus and the inferior end plate of the T12 vertebra corpus.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Spinal Deformity- The Modified Cobb Angle (Researcher 1)	35.33 degrees Standard Deviation 12.62	34.33 degrees Standard Deviation 6.84

SECONDARY outcome

Timeframe: Before treatment

The Modified Cobb angle was found on lateral scoliosis graphs by the angle between the superior end plate of the T4 vertebra corpus and the inferior end plate of the T12 vertebra corpus.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Spinal Deformity- The Modified Cobb Angle (Researcher 2)	34.67 degrees Standard Deviation 11.76	33.11 degrees Standard Deviation 7.4

SECONDARY outcome

Timeframe: 6 months

The Modified Cobb angle was found on lateral scoliosis graphs by the angle between the superior end plate of the T4 vertebra corpus and the inferior end plate of the T12 vertebra corpus.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Spinal Deformity- The Modified Cobb Angle (Researcher 1)	35.5 degrees Standard Deviation 8.09	32.33 degrees Standard Deviation 3.08

SECONDARY outcome

Timeframe: 6 months

The Modified Cobb angle was found on lateral scoliosis graphs by the angle between the superior end plate of the T4 vertebra corpus and the inferior end plate of the T12 vertebra corpus.

Outcome measures

Outcome measures
Measure	Pulmonary Rehabilitation+Exercise Group n=10 Participants Active cycle of breathing techniques (ACBT) and postural exercise program Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks. Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.	Pulmonary Rehabilitation Group n=9 Participants Active cycle of breathing techniques (ACBT) Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.
Spinal Deformity- The Modified Cobb Angle (Researcher 2)	35 degrees Standard Deviation 7.87	32.4 degrees Standard Deviation 3.33

Adverse Events

Pulmonary Rehabilitation+Exercise Group

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Pulmonary Rehabilitation Group

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Kardelen Gencer Atalay

Marmara University

Phone: 5324404887

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place