Venous Ulcer: Endovenous Radiofrequency Treatment Trial

NCT ID: NCT03293836

Last Updated: 2017-09-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-01

Study Completion Date

2018-08-31

Brief Summary

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The aim of this study is to analyze the effect of intravenous therapy with radiofrequency for superficial and perforating venous insufficiency versus compression therapy with multilayer banding in patients with active venous ulcer. This is a controlled, randomized prospective clinical trial. People with venous ulcers and primary venous insufficiency in superficial and perforating venous system will be studied. Participants will be divided into two experimental groups: compression therapy alone, and compression therapy associated with superficial and perforating venous system ablation. Clinical aspects, improvement in patients' quality of life and interventions cost-effectiveness will be analyzed. Patients will be followed for 12 months after ulcer healing.

Detailed Description

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Conditions

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Varicose Ulcer Varicose Veins of Lower Limb Saphenous Vein Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Radiofrequency treatment

Radiofrequency ablation of insufficient saphenous and perforating veins plus multilayer compressive bandage treatment

Group Type EXPERIMENTAL

Radiofrequency ablation

Intervention Type PROCEDURE

Radiofrequency ablation of insufficient saphenous and perforating veins using Closure Fast and Closure Stylet catheters (medtronic)

Multilayer Compressive Bandage

Intervention Type PROCEDURE

Individual receive multilayer compressive bandage once a week

Multilayer Compressive Bandage only

Receive only compressive treatment

Group Type ACTIVE_COMPARATOR

Multilayer Compressive Bandage

Intervention Type PROCEDURE

Individual receive multilayer compressive bandage once a week

Interventions

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Radiofrequency ablation

Radiofrequency ablation of insufficient saphenous and perforating veins using Closure Fast and Closure Stylet catheters (medtronic)

Intervention Type PROCEDURE

Multilayer Compressive Bandage

Individual receive multilayer compressive bandage once a week

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* age between 18 and 80 years old
* venous ulcer appeared at least 4 weeks, bellow knee
* ankle-brachial index more than 0.9
* saphenous veins insufficiency plus perforating veins reflux
* saphenous vein diameter between 5 mm and 12 mm
* absence of saphenous veins thrombophlebitis
* absence of personal history of venous deep thrombosis
* absence of ultrasound evidence of actual or previous venous deep thrombosis
* absence of severe ankle anquilosis

Exclusion Criteria

* Unable to provide informed consent
* Unable to receive surgical intervention due to severe clinical condition
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fundação de Amparo à Pesquisa do Estado de São Paulo

OTHER_GOV

Sponsor Role collaborator

Juliana Puggina

OTHER

Sponsor Role lead

Responsible Party

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Juliana Puggina

MD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Igor R Sincos, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo

Juliana Puggina, MD

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo

Locations

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Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (University of São Paulo)

São Paulo, São Paulo, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Juliana Puggina, MD

Role: CONTACT

+5511988604601

Igor R Sincos, PhD

Role: CONTACT

+5511984477382

Facility Contacts

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Juliana Puggina, MD

Role: primary

+5511988604601

Debora Nolli

Role: backup

+5511999707101

References

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Puggina J, Sincos IR, Campos W Jr, Porta RMP, Dos Santos JB, De Luccia N, Puech-Leao P, Collares FB, da Silva ES. A randomized clinical trial of the effects of saphenous and perforating veins radiofrequency ablation on venous ulcer healing (VUERT trial). Phlebology. 2021 Apr;36(3):194-202. doi: 10.1177/0268355520951697. Epub 2020 Sep 14.

Reference Type DERIVED
PMID: 32928070 (View on PubMed)

Other Identifiers

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UTN

Identifier Type: OTHER

Identifier Source: secondary_id

Vuert trial

Identifier Type: -

Identifier Source: org_study_id