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Effects of DHA on Post-operative Fibrosis of Trabulectomy Blebs in Glaucoma Surgery

NCT ID: NCT03289806

Last Updated: 2017-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-12

Study Completion Date

2018-01-31

Brief Summary

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Post-operative fibrosis of trabulectomy blebs is a major cause of surgical failure leading to a renewed increase in intraocular pressure. The use of anti-metabolites over many years has made it possible to improve success rates for this surgery but these drugs have numerous adverse effects as they are toxic. Alternative therapies are thus necessary, and we believe that DHA could have antifibrotic effects on fibroblasts and could thus improve success rates in this surgery.

Detailed Description

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Conditions

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Trabulectomy Deep Sclerectomy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Cases

Glaucoma surgery

Samples of fibroblasts from Tenon's capsule

Intervention Type PROCEDURE

Controls

Strabismus surgery

Samples of fibroblasts from Tenon's capsule

Intervention Type PROCEDURE

Interventions

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Samples of fibroblasts from Tenon's capsule

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing trabulectomy or deep sclerectomy
* Patients informed about the study

Exclusion Criteria

\- Patients who refuse to take part in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire Dijon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Chu Dijon Bourogne

Dijon, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Alain BRON

Role: CONTACT

[email protected]
03 80 29 37 56 ext. +33

Facility Contacts

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Alain BRON

Role: primary

[email protected]
03 80 29 37 56 ext. +33

Other Identifiers

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DELAZZER 2016

Identifier Type: -

Identifier Source: org_study_id