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Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

NCT ID: NCT03288662

Last Updated: 2017-09-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

2 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-01

Study Completion Date

2017-07-31

Brief Summary

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the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

Detailed Description

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1. Introduction: the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.
2. Materials and methods:

2.1. Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors

2.2. Time and Place: in Departement of CTVS, Military Hospital 103, Vietnam from 10/2013 to 7/2017.

2.3. methods:
* study in chest CT scan:

* Measure the maximun diameter of the tumor
* The contour: smooth contour or irregular contour
* The shape: round, oval and plaque base on the ratio between long axis and short axis of the tumor
* Some other characteristics: Degree of enhancement, Level of drug absorbed, Calcification, Invasion the local organs and Capsular destruction.
* Histopathological study: based on the 2004 WHO classification:

* Thymoma: type A, AB, B1, B2, B3
* Thymic carcinoma
* Data processing: use software Epi Info 2000.
3. Expectation of results

* Relationship between the size and histopathological type of thymic epithelial tumors.
* Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors

Conditions

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Thymoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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CT and histopathological classification

With each histopathological type of thymic epithelial tumors, we measure the maximun diameter in chest CT scan. Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors .

Group Type EXPERIMENTAL

CT and histopathological classification

Intervention Type OTHER

Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors. Base on the characteristics in Chest CT scan in each postoperative histopathology results.

Interventions

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CT and histopathological classification

Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors. Base on the characteristics in Chest CT scan in each postoperative histopathology results.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All of patient have a chest CT scan pre-operation and a result of thymic epithelial tumors postoperative histopathology

Exclusion Criteria

* Incomplete or loss the CT and postoperative histopathology
Minimum Eligible Age

21 Years

Maximum Eligible Age

71 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nguyen Truong Giang

UNKNOWN

Sponsor Role collaborator

Military Hospital 103

OTHER

Sponsor Role lead

Responsible Party

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Le Viet Anh, MD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Truong Giang Nguyen, PhD

Role: STUDY_CHAIR

VMMU

Other Identifiers

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LAnh

Identifier Type: -

Identifier Source: org_study_id