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The Impact of Misclassification of Obesity by Body Mass Index on Mortality in Patients With Chronic Kidney Disease

NCT ID: NCT03285074

Last Updated: 2017-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

326 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-11-01

Study Completion Date

2017-03-31

Brief Summary

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Unlike the general population, a higher body mass index (BMI) is associated with greater survival among patients with chronic kidney disease (CKD). However, obesity is defined as excess body fat that associated with clearly elevated health risks according to the World Health Organization. In addition, muscle wasting is prevalent among CKD subjects. Thus, we hypothesized that different definition of obesity, based on BMI or body fat percentage, might have different impact on clinical outcomes among CKD population.

Detailed Description

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Conditions

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Chronic Kidney Diseases Obesity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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No intervention

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subjects with non-dialysis CKD defined as estimated glomerular filtration rate (eGFR) \<60 ml/min/1.73 m2

Exclusion Criteria

* subjects with liver cirrhosis
* subjects with malignancy
* subjects with an acute cardiovascular event within the 3 months before screening for inclusion
* amputee
* pregnancy
* subjects with pacemaker
* subjects with metallic implant
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

OTHER

Sponsor Role lead

Responsible Party

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Szu-Chun Hung

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Szu-Chun Hung, MD

Role: PRINCIPAL_INVESTIGATOR

Division of nephrology, Taipei Tzu Chi Hospital

References

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Sharma D, Hawkins M, Abramowitz MK. Association of sarcopenia with eGFR and misclassification of obesity in adults with CKD in the United States. Clin J Am Soc Nephrol. 2014 Dec 5;9(12):2079-88. doi: 10.2215/CJN.02140214. Epub 2014 Nov 12.

Reference Type RESULT
PMID: 25392147 (View on PubMed)

Agarwal R, Bills JE, Light RP. Diagnosing obesity by body mass index in chronic kidney disease: an explanation for the "obesity paradox?". Hypertension. 2010 Nov;56(5):893-900. doi: 10.1161/HYPERTENSIONAHA.110.160747. Epub 2010 Sep 27.

Reference Type RESULT
PMID: 20876448 (View on PubMed)

Gracia-Iguacel C, Qureshi AR, Avesani CM, Heimburger O, Huang X, Lindholm B, Barany P, Ortiz A, Stenvinkel P, Carrero JJ. Subclinical versus overt obesity in dialysis patients: more than meets the eye. Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv175-81. doi: 10.1093/ndt/gft024.

Reference Type RESULT
PMID: 24179011 (View on PubMed)

Lin TY, Liu JS, Hung SC. Obesity and risk of end-stage renal disease in patients with chronic kidney disease: a cohort study. Am J Clin Nutr. 2018 Nov 1;108(5):1145-1153. doi: 10.1093/ajcn/nqy200.

Reference Type DERIVED
PMID: 30321257 (View on PubMed)

Lin TY, Lim PS, Hung SC. Normal-weight obesity and clinical outcomes in nondiabetic chronic kidney disease patients: a cohort study. Am J Clin Nutr. 2018 Apr 1;107(4):664-672. doi: 10.1093/ajcn/nqy006.

Reference Type DERIVED
PMID: 29635500 (View on PubMed)

Other Identifiers

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99-IRB-016-XD

Identifier Type: -

Identifier Source: org_study_id