The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection
NCT ID: NCT03273231
Last Updated: 2019-01-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
100 participants
INTERVENTIONAL
2017-09-01
2020-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
TRIPLE
Study Groups
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ketamine group
Ketamine is administered intravenously with a loading dose of 0.25 mg/kg at 5 minutes before surgery, followed by an infusion rate of 0.05 mg/kg/h to the end of surgery.
Ketamine
Ketamine is administered intravenously with a loading dose of 0.25 mg/kg at 5 minutes before surgery, followed by an infusion rate of 0.05 mg/kg/h to the end of surgery.
control group
0.9% saline solution
Saline
0.9% saline solution
Interventions
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Ketamine
Ketamine is administered intravenously with a loading dose of 0.25 mg/kg at 5 minutes before surgery, followed by an infusion rate of 0.05 mg/kg/h to the end of surgery.
Saline
0.9% saline solution
Eligibility Criteria
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Inclusion Criteria
* patient scheduled for laparoscopic colorectal cancer resection
Exclusion Criteria
* severe hepatorenal disease
* heart failure
* infection
* increased intracranial pressure, seizure
* preoperative chemotherapy
* immune or endocrine disease
* metastasis to other organ
* problem with communication
* pregnancy
* body mass index \> 35 kg/m2
20 Years
80 Years
ALL
No
Sponsors
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Yonsei University
OTHER
Responsible Party
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Locations
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Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Seoul, , South Korea
Countries
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Central Contacts
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Facility Contacts
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References
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Cho JS, Kim NY, Shim JK, Jun JH, Lee S, Kwak YL. The immunomodulatory effect of ketamine in colorectal cancer surgery: a randomized-controlled trial. Can J Anaesth. 2021 May;68(5):683-692. doi: 10.1007/s12630-021-01925-3. Epub 2021 Feb 2.
Other Identifiers
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4-2017-0475
Identifier Type: -
Identifier Source: org_study_id
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