COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

281 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-22

Study Completion Date

2025-05-12

Brief Summary

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Despite combined antiretroviral therapy (cART), milder forms of HIV-associated neurocognitive disorders (HAND) persist in 20-50% of persons living with HIV (PLHIV). Since more PLH are at risk for HAND due to aging, the frequency of HAND in PLHIV ≥ 65 years old is important to quantify for planning early intervention to attenuate both functional and occupational disabilities due to cognitive impairment.

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Detailed Description

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Conditions

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Memory Impairment HIV/AIDS Cognitive Impairment

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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people living with HIV

subjects infected with HIV and with cognitive complaints

assessment of cognitive impairment

Intervention Type OTHER

Measure of Global Deficit Score

control subjects

subjects not infected with HIV and with cognitive complaints

assessment of cognitive impairment

Intervention Type OTHER

Measure of Global Deficit Score

Interventions

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assessment of cognitive impairment

Measure of Global Deficit Score

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Personal or familial cognitive complaints
* Individual aged ≥ 65 years old and \< 81 years old
* Instrumental activities of daily living (IADL) score between 3-4
* French speaking individual
* Informed consent signed For PLHIV
* HIV infection
* Undetectable HIV viral load ≥ 1 year
* Current cluster of differentiation (CD4) cell count \> 100/mm3 For controls
* negative HIV serology ≤ 6 months