A Laboratory Scan of Patients With Aortic Aneurysms to IgG4 Levels in the Blood
NCT ID: NCT03267875
Last Updated: 2017-11-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
300 participants
INTERVENTIONAL
2017-11-08
2018-10-01
Brief Summary
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The properties that bind them are: lesions similar to tumors in the mixed organs, lymphoplasms filtrate enriched with plasma IgG4 positive cells, storiform fibrosis, and often, but not always, a high level of IgG4 in the serum.
This disease has been on the rise for the past two decades and since its recognition in 2001 there has been impressive progress in understanding its various manifestations, so that today almost every body system can be involved.
One of the conditions associated with this disease is oritis / periortitis and aneurysms
Detailed Description
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The properties that bind them are: lesions similar to tumors in the mixed organs, lymphoplasms filtrate enriched with plasma IgG4 positive cells, storiform fibrosis, and often, but not always, a high level of IgG4 in the serum.
This disease has been on the rise for the past two decades and since its recognition in 2001 there has been impressive progress in understanding its various manifestations, so that today almost every body system can be involved.
One of the conditions associated with this disease is oritis / periortitis and aneurysms
It is common to divide the aortic aneurysms according to the following etiologies:
1. Inflammatory-Aortic Aneurisms (IAA) The internal division in this category is whether IgG4RD is related / not related.
2. Atherosclerotic infrastructure.
Differences between the etiologies: IAA - greater thickness of the wall, fibrosis and adhesion to nearby retroperitone structures. Also, younger age and non-specific symptoms. In addition, the laboratory findings are usually white counts and increased CRP.
In this context, the investigators will examine the level of IgG4 in the blood of a population of patients with aortic aneurysms and try to understand the proportion of patients whose IgG4 level is higher than normal and their aneurysm can be attributed to IgG4 Related Disease.
the investigator chose the blood IgG4 level because it is the most important diagnostic variable for the disease (it is customary to place the incision point at \> 135mg / dL).
Conditions
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Study Design
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NA
SINGLE_GROUP
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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single arm
Patients after aneurysm in the aorta, Men and women aged 18-100 (not including special populations), who are able to read understand and sign a written consent to participate in the research
Blood Test
draw out 2 blood tubes from a patient
Interventions
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Blood Test
draw out 2 blood tubes from a patient
Eligibility Criteria
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Inclusion Criteria
* Men and women aged 18-100 (not including special populations)
* Those who are able to read understand and sign a written consent to participate in the research
18 Years
100 Years
ALL
No
Sponsors
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Meir Medical Center
OTHER
Responsible Party
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yair levy
Professor
Principal Investigators
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Yael Eizikovits, B.A
Role: STUDY_CHAIR
Meir Medical Center
Locations
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Yael Eizikovits
Kfar Saba, , Israel
Countries
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Central Contacts
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Other Identifiers
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Aneurysm-IgG4
Identifier Type: -
Identifier Source: org_study_id