Hydrus Microstent for Refractory Open-Angle Glaucoma

NCT ID: NCT03267134

Last Updated: 2023-12-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

217 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-08-01

Study Completion Date

2022-12-16

Brief Summary

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The purpose of this study is to assess the safety and effectiveness of the Hydrus Microstent in patients with refractory open-angle glaucoma.

Detailed Description

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Participants will attend a screening visit, a baseline visit, a surgery visit, and 8 post-operative visits (Day 1, Day 7, Month 1, Month 2, Month 3, Month 6, Month 9, Month 12), for a total individual duration of approximately 14 months.

Conditions

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Open-angle Glaucoma

Keywords

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Glaucoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Hydrus Microstent

Hydrus Microstent implanted in the eye per the supplied Hydrus Microstent Instructions for Use and associated training. Only one eye (study eye) will be implanted.

Group Type EXPERIMENTAL

Hydrus Microstent

Intervention Type DEVICE

Device implanted into the Schlemm's canal of the eye for the purpose of providing a natural outflow pathway for aqueous humor. The Hydrus Microstent is intended for lifetime use of the glaucoma patient.

Ophthalmic surgery

Intervention Type PROCEDURE

Implantation of the Hydrus Microstent performed under either local or topical ophthalmic anesthesia

Interventions

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Hydrus Microstent

Device implanted into the Schlemm's canal of the eye for the purpose of providing a natural outflow pathway for aqueous humor. The Hydrus Microstent is intended for lifetime use of the glaucoma patient.

Intervention Type DEVICE

Ophthalmic surgery

Implantation of the Hydrus Microstent performed under either local or topical ophthalmic anesthesia

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Open-angle glaucoma with optic nerve pathology;
* Best Corrected Visual Acuity of 20/80 or better in study eye;
* Refractory glaucoma;

Exclusion Criteria

* Secondary glaucoma other than pseudoexfoliative and pigmentary glaucoma;
* Acute angle closure, chronic angle closure, or congenial, malignant, or developmental glaucoma;
* Pre-perimetric glaucoma;
* Ocular hypertension
* Shallow or flat anterior chamber;
Minimum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ivantis, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Project Lead, CRD Surgical

Role: STUDY_DIRECTOR

Alcon Research, LLC

Locations

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Vold Vision

Fayetteville, Arkansas, United States

Site Status

Sacramento Eye Consultants

Sacramento, California, United States

Site Status

Eye Center of Northern Colorado

Fort Collins, Colorado, United States

Site Status

Ocala Eye

Ocala, Florida, United States

Site Status

Center for Sight

Venice, Florida, United States

Site Status

Stiles Eyecare

Overland Park, Kansas, United States

Site Status

Louisiana Eye and Laser Center

Alexandria, Louisiana, United States

Site Status

Washington University in St. Louis Ophthalmology

St Louis, Missouri, United States

Site Status

Scott & Christie and Associates

Cranberry Township, Pennsylvania, United States

Site Status

Texan Eye

Austin, Texas, United States

Site Status

Glaucoma Associates of Texas

Dallas, Texas, United States

Site Status

El Paso Eye Surgeons

El Paso, Texas, United States

Site Status

Ophthalmology Associates

Fort Worth, Texas, United States

Site Status

Vale-Asche Russell Clinical Research Center

Houston, Texas, United States

Site Status

R and R Research, LLC

San Antonio, Texas, United States

Site Status

The Eye Centers of Racine and Kenosha

Kenosha, Wisconsin, United States

Site Status

Clínica Oftalmológica

Barranquilla, , Colombia

Site Status

Asian Eye Institute

Makati City, , Philippines

Site Status

Hospital Universitario Miguel Servet

Zaragoza, , Spain

Site Status

Manchester Royal Eye Hospital

Manchester, , United Kingdom

Site Status

Countries

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United States Colombia Philippines Spain United Kingdom

Other Identifiers

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CP 16-001

Identifier Type: -

Identifier Source: org_study_id