Efficacy and Safety of Apatinib As Third Line Therapy in Patients With Advanced Ovarian Cancer

NCT ID: NCT03262545

Last Updated: 2017-08-28

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-08-27
• Study Completion Date: 2021-02-28

Brief Summary

The study is to investigate the efficacy and safety of apatinib in patients with advanced ovarian cancer,who has received second-line chemotherapy and failed.

Detailed Description

Ovarian cancer is the third most common gynecological malignancy，just less than endometrial cancer and cervical cancer. Because most patients with advanced ovarian cancer can not get the ideal tumor cell reduction surgery, and multi-drug resistance often emerges after repeated chemotherapy，recurrent and metastatic ovarian cancer has become one of the major diseases that threaten women's health. There is strongly necessary to explore effective therapeutic drugs and means to improve prognosis of these patients and improve the quality of life. The study，as a double blind clinical trial ,is to investigate the efficacy and safety of apatinib in patients with advanced ovarian cancer,who has received second-line chemotherapy regimens and failed. A total of 60 patients with performance status 0-2 were enrolled in this study, and were randomly divided into two groups--one group of 40 patients receiving apatinib，and another of 20 patients receiving placebo.

Conditions

Angiogenesis Inhibitors，Ovarian Neoplasms

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

experimental group

apatinib 500 mg p.o. once daily

Group Type: EXPERIMENTAL

apatinib

Intervention Type: DRUG

Patients in experimental group will take 500mg apatinib daily orally，and patients in control group will take placebo

control group

placebo p.o. once daily

Group Type: PLACEBO_COMPARATOR

Placebos

Intervention Type: DRUG

Physical properties of placebos are consistent with apatinib

Interventions

apatinib

Patients in experimental group will take 500mg apatinib daily orally，and patients in control group will take placebo

Intervention Type: DRUG

Placebos

Physical properties of placebos are consistent with apatinib

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. 18 years to 70 years;

2. Had a histologically or cytologically confirmed diagnosis of epithelial ovarian cancer；

3. unfit for radical surgery and had received second-line chemotherapy，the disease still progressed or can not tolerate the chemotherapy;

4. Had a disease status that was measurable or evaluable as defined by Response Evaluation Criteria in Solid Tumors (RECIST, version1.1);

5. Had an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1, or 2;

6. Had a life expectancy of at least 12 weeks;

7. Adequate hepatic, renal, heart, and hematologic functions (hemoglobin ≥90g/L, platelets ≥ 80×10^9/L, neutrophils ≥ 1.5×10^9/L, total bilirubin within 1.5×the upper limit of normal (ULN), and b) ALT and AST≤2.5×the ULN (If liver metastases, serum creatine ≤ 1.5 x ULN);

8. Had not gastrointestinal diseases that lead to malabsorption or impact Drug absorption;

9. had good compliance;

10. Signed and dated informed consent.

Exclusion Criteria

1. patients who had received anti-vascular therapy;

2. Allergic to any ingredients of Apatinib;

3. Participated in other drug clinical researchers within four weeks;

4. Have a variety of factors that affect oral medication (such as can not swallow, gastrointestinal resection, chronic diarrhea and intestinal obstruction, etc.)

5. Severe infection;

6. Patients with serious cardiovascular diseases,such as unstable angina, grade 3-4 heart dysfunction (NYHA Standard), congestive heart failure, poor-controlled arterial hypertension despite standard medical management;

7. Patients who received major surgical operations within 4 weeks before screening;

8. Patients who manifested arterial/venous thrombus events, e.g.cerebrovascular accident (including transient ischemic attack), deep venous thrombosis and pulmonary embolism, etc., within 12 months before screening;

9. Past or concurrent with other malignancies, except for cured skin basal cell carcinoma and cervical in situ cancer;

10. Have a history of psychiatric abuse and can not quit or have mental disorders.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Sichuan Cancer Hospital and Research Institute

OTHER

Sponsor Role: lead

Responsible Party

Mei Kai

associate senior doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Sichuan Cancer Hospital

Chengdu, Sichuan, China

Site Status: RECRUITING

Countries

China

Central Contacts

Mei Kai, Ph.D

Role: CONTACT

250450418@qq.com

18111277629

Facility Contacts

Kai Mei, Phd

Role: primary

250450418@qq.com

13011827280

References

Gaitskell K, Rogozinska E, Platt S, Chen Y, Abd El Aziz M, Tattersall A, Morrison J. Angiogenesis inhibitors for the treatment of epithelial ovarian cancer. Cochrane Database Syst Rev. 2023 Apr 18;4(4):CD007930. doi: 10.1002/14651858.CD007930.pub3.

Reference Type: DERIVED

PMID: 37185961 (View on PubMed)

Other Identifiers

Ahead-OV-201704

Identifier Type: -

Identifier Source: org_study_id