The Effect of Obstructive Sleep Apnea and Its Treatment on Decision Making

NCT ID: NCT03262519

Last Updated: 2022-03-07

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 96 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-07-20
• Study Completion Date: 2022-12-01

Brief Summary

Obstructive sleep apnea (OSA) is an extremely common disease with inadequately explored neurocognitive consequences. The investigators will study OSA patients before and after treatment to understand how OSA changes decision making abilities, and whether treatment can reverse such cognitive changes. These results could provide deeper insight into how OSA affects decision making either temporarily or permanently, and provide another rationale or motivation for treatment of OSA in adults.

Detailed Description

The investigators hypothesize that OSA will lead to (H1) more reward-seeking and lower payoffs in the Iowa Gambling task, replicating previous findings; (H2) greater discounting of future rewards in financial choices; and (H3) these effects would dissipate when OSA is successfully treated.

In order to test these hypotheses, the investigators will perform cognitive tests (Iowa gambling; intertemporal choice; other measures) in 100 patients about to undergo sleep testing. It is expected that of these 100 patients, some will have no sleep apnea; some will have sleep apnea and will be successfully treated; and that some will have sleep apnea but will not be successfully treated by the time of repeat testing. The investigators will repeat testing using the same instruments 2 months later.

Thus the investigators will be able to compare whether OSA patients differ from control at baseline (t1), and whether OSA patients' performance will improve after treatment at t2, compared to the control at t2.

Conditions

Obstructive Sleep Apnea

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients at UCSD Sleep Medicine Clinic

Patients referred for sleep testing (either home sleep testing or in-lab full polysomnography) will be approached for participation.

Computer based neurocognitive testing

Intervention Type: DIAGNOSTIC_TEST

Iowa Gambling Task, The Balloon Task, Intertemporal choices task, Cognitive Reflection Test, Physiological and self-reported measures of OSA/sleep related symptoms, General health and physiological measures.

Interventions

Computer based neurocognitive testing

Iowa Gambling Task, The Balloon Task, Intertemporal choices task, Cognitive Reflection Test, Physiological and self-reported measures of OSA/sleep related symptoms, General health and physiological measures.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

Subjects aged 18-75 referred to the UCSD Sleep clinic for either home or in-laboratory testing will be considered for inclusion in the study. Inclusion will not depend on gender, race or ethnicity, as per the following:

1. 100 participants will be enrolled at the UCSD Sleep Clinic at Chancellor Park.

2. Ages 18-75

3. Gender: Men and woman

4. Ethnic background: All

5. Health Status: to the UCSD Sleep clinic for either home or in-laboratory testing

Exclusion Criteria

1. Ongoing CPAP treatment for OSA

2. Inability to use a tablet device (e.g. no reading glasses, or unfamiliar with devices).

3. Severe cardiopulmonary disorder that requires treatment with supplemental oxygen therapy.

4. Inability to speak English fluently, as some of the questionnaires/tests are only validated in English.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of California, San Diego

OTHER

Sponsor Role: lead

Responsible Party

Robert L. Owens

Assistant Clinical Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of California, San Diego

San Diego, California, United States

Countries

United States

Other Identifiers

170683

Identifier Type: -

Identifier Source: org_study_id