Can we Train Patients With Chronic Stroke Out of Abnormal Hand Synergy?
NCT ID: NCT03255590
Last Updated: 2021-11-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2017-03-03
2020-12-30
Brief Summary
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Detailed Description
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Three functional aspects of each finger will be tested: maximal voluntary contraction (MVC), finger dexterity, and hand posture.
Prior to intervention, participants will have a baseline assessment including clinical tests, MVC, the individuation task, and the configuration task. Following the baseline assessment patients will receive intervention, training on the configuration task for 5 consecutive days. On the sixth day and as a one week follow-up after, subjects will have a post-intervention assessment containing the same tests performed in baseline.
This design will allow us to determine speed and accuracy during the configuration task, the individuation index, and possible changes in abnormal flexion synergy.
We initially registered the study as two arms (anodal tDCS and sham tDCS groups) but decided to make it one arm due to the number of participants we were able to recruit.
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Finger Dexterity Training
Chronic stroke patients (i.e. great than 6 months) with ischemic stroke confirmed by CT or MRI, residual unilateral upper extremity weakness, able to give informed consent, and able to understand the tasks involved.
Participants trained for 5 consecutive days, 3 to 4 h/d, on a multi-finger piano-chord-like task that cannot be performed by compensatory actions of other body parts (e.g., arm). Participants had to learn to simultaneously coordinate and synchronize multiple fingers to break unwanted flexor synergies.
Configuration task
Training the impaired hand on a configuration task
Interventions
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Configuration task
Training the impaired hand on a configuration task
Eligibility Criteria
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Inclusion Criteria
* Ischemic stroke greater than six months ago, confirmed by CT or MRI
* Residuals unilateral upper extremity weakness
* Ability to give informed consent and understand the tasks involved.
* Appearance of Flexion synergy in hand.
* Ability to extent finger at least for 5 degrees.
Exclusion Criteria
* History of physical or neurological condition that interferes with study procedures or assessment of motor function (e.g. severe arthritis, severe neuropathy, Parkinson's disease)
* Contraindication to tDCS (deep brain stimulators or other metal in the head, skull defect, pacemaker)
* Inability to sit in a chair and perform upper limb exercises for one hour at a time
* Participation in another upper extremity rehabilitative therapy study or tDCS study during the study period
* Terminal illness
* Social and/or personal circumstances that interfere with ability to return for therapy sessions and follow up assessments
* Pregnancy
* Severe Neglect
21 Years
99 Years
ALL
No
Sponsors
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Johns Hopkins University
OTHER
Responsible Party
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Principal Investigators
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Pablo Celnik
Role: PRINCIPAL_INVESTIGATOR
Department of Physical Medicine and Rehabilitation Johns Hopkins University
Locations
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Kennedy Krieger Institute
Baltimore, Maryland, United States
Countries
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Other Identifiers
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NA_00082367
Identifier Type: -
Identifier Source: org_study_id