trūFreeze® Palliative Esophageal Cancer

NCT ID: NCT03243734

Last Updated: 2024-05-08

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 49 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-11-06
• Study Completion Date: 2024-03-06

Brief Summary

Prospective, open label, non-controlled single arm, multi-center study The primary objective is to study the effects of the trūFreeze® Spray Cryotherapy System in a population of subjects who have been diagnosed with persistent local esophageal cancer and who are not surgical candidates or have completed or declined systemic therapy.

Detailed Description

The use of cryotherapy delivered with the trūFreeze® System via noncontact spray ablates the cancer cells while allowing adjacent normal tissue to regenerate. When the liquid nitrogen is delivered to the malignant lesion the cancer cells undergo ablation induced by intracellular water being frozen in place such that ice crystals are formed. These ice crystals aggregate quickly causing immediate intracellular energy producing organelles to be destroyed leading to a non-viable cell. Subsequent tumor sloughing and absorption of apoptotic cells occurs with a subsequent debulking of the tumor mass. Normal tissue will regenerate as re-epithelialization occurs. The extreme cold of -196 degrees Celsius or a "hard freeze" leads to more extensive primary cell death over a shorter freeze time as compared to cryoprobes. A reduction of overall tumor obstruction in the esophageal lumen can reduce symptoms of dysphagia, delay the time until stent is needed, provide palliative care for patients for whom additional tri-modal therapies are not an option, and may increase quality of life in esophageal cancer patients. The studies conducted to date have provided documentation of the safety and effectiveness of spray cryotherapy (SCT) when used for malignancies in the esophagus. Measures of dysphagia relief have been described in peer reviewed literature. This study aims to provide much needed HRQOL information as well as additional tumor characteristics before and after SCT. A cohort of patients with locally persistent esophageal cancer will be studied in up to twelve (12) centers in the United States to provide important HRQOL data and more a comprehensive understanding of clinical tumor response post SCT. In the proposed study, the trūFreeze® System spray cryotherapy procedure will be performed during endoscopy. Each SCT procedure will be performed endoscopically at clinically indicated intervals of 6 weeks +/- 3 weeks. Total procedure dosimetry will be delivered at the discretion of the Investigator based on tumor location and patient tolerability. After each procedure at defined intervals, patients will be contacted and QOL symptom related information will be collected. If at any point an Investigator determines that a subject is not a candidate for further spray cryotherapy or is unable to tolerate additional procedures, they will be contacted via telephone to ascertain HRQOL information. Subject participation will last up to two years or until death

Conditions

Esophageal Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: NONE

Study Groups

trūFreeze® System spray cryotherapy

trūFreeze® System spray cryotherapy as clinically indicated for symptom relief

Group Type: EXPERIMENTAL

trūFreeze® System spray cryotherapy

Intervention Type: DEVICE

Subjects where trūFreeze® System spray cryotherapy is performed

Interventions

trūFreeze® System spray cryotherapy

Subjects where trūFreeze® System spray cryotherapy is performed

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Males and females of 18 to 89 years of age.
• Subject is able to read, understand, and sign a written Informed Consent to participate in the study.
• Subject has persistent esophageal cancer with local luminal involvement and who is not a surgical candidate or has completed or declined systemic therapy.
• Subject is able to tolerate endoscopy

Exclusion Criteria

• Subject is pregnant, nursing, or planning to get pregnant during study duration.
• Subjects with an esophageal stent in situ at the time of study enrollment
• Subject, as deemed by treating investigator has contraindication to endoscopy or Spray Cryotherapy Procedure.
• Subject has received radiation within the past 6 weeks
• Subject has received chemotherapy within the past 2 weeks Subject has received immunotherapy within 30 days
• Subject has participated in another clinical study for systemic therapy within 6 weeks of baseline.
• Subject has had previous Spray Cryotherapy for esophageal cancer.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 89 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

US Endoscopy Group Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Nicholas Shaheen, MD

Role: PRINCIPAL_INVESTIGATOR

University of North Carolina, Chapel Hill

Locations

Cancer Treatment Centers of America Western Regional Medical Center

Goodyear, Arizona, United States

University of California at Irvine

Orange, California, United States

Emory University

Atlanta, Georgia, United States

Parkview Comprehensive Cancer Center

Fort Wayne, Indiana, United States

Spectrum Health

Grand Rapids, Michigan, United States

Dartmouth-Hotchcock Medical Center

Lebanon, New Hampshire, United States

North Shore-Long Island Jewish Medical Center

Manhasset, New York, United States

University of Rochester

Rochester, New York, United States

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Virginia Commonwealth University

Richmond, Virginia, United States

Countries

United States

Other Identifiers

017

Identifier Type: -

Identifier Source: org_study_id