Silver Nanoparticle Investigation for Treating Chronic Sinusitis
NCT ID: NCT03243201
Last Updated: 2018-05-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
PHASE1
INTERVENTIONAL
2018-01-31
2018-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Colloidal Silver
The colloidal silver arm will administer intranasal colloidal silver, 2 sprays each nostril twice daily, for a total volume of 0.8ml per day (8 mcg of silver per day), for 28 days.
Colloidal silver nanoparticles
Contains 10ppm colloidal silver nanoparticles
Purified Water
The placebo arm will administer intranasal purified water, 2 sprays each nostril twice daily, for a total volume of 0.8ml per day, for 28 days.
Purified Water
Purified water will be given as placebo
Interventions
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Colloidal silver nanoparticles
Contains 10ppm colloidal silver nanoparticles
Purified Water
Purified water will be given as placebo
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* mucopurulent drainage (anterior, posterior, or both), nasal obstruction (congestion), facial pain-pressure-fullness, or decreased sense of smell
AND inflammation is documented by one or more of the following findings:
* purulent (not clear) mucus or edema in the middle meatus or ethmoid region
* polyps in nasal cavity or the middle meatus
* and/or radiographic imaging showing inflammation of the paranasal sinuses
Exclusion Criteria
* History of nasal or sinus surgery within past 6 weeks
* History of comorbid ciliary dyskinesia, cystic fibrosis or any other mucociliary condition
* Dependence on prolonged corticosteroid therapy for comorbid condition
* History of renal impairment
* History of cerebrospinal fluid leak
18 Years
ALL
Yes
Sponsors
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Washington University School of Medicine
OTHER
Responsible Party
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Other Identifiers
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159084
Identifier Type: -
Identifier Source: org_study_id
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