Ipilimumab and Nivolumab as Adjuvant Treatment of Mucosal Melanoma

NCT ID: NCT03241186

Last Updated: 2022-12-09

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 36 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-09-12
• Study Completion Date: 2023-09-30

Brief Summary

This is a single arm phase II clinical trial of Ipilimumab and Nivolumab in patients with resected mucosal melanoma. Ipilimumab (1 mg/kg) and Nivolumab (3 mg/kg) will be administered Day 1 of a 21-day cycle in Cycles 1-4 and then nivolumab 480 mg will be administered Day 1 of a 28-day cycle for Cycles 5-15 (maximum of 15) or until disease recurrence or intolerance before completion of 15 cycles.

Detailed Description

Ipilimumab and Nivolumab Combination Administration

• Ipilimumab 1mg/kg given IV Day 1 for 3 weeks (21 days), for 4 cycles
• Nivolumab 3mg/kg given IV Day 1 for 3 weeks (21 days), for 4 cycles

Nivolumab Alone Administration

• Nivolumab 480mg given IV Day 1 for 4 weeks (28 days), for 5-15 cycles

Nivolumab is to be administered as an approximately 30-minute IV infusion (± 10 minutes). At the end of the infusion, flush the line with a sufficient quantity of normal saline.

Ipilimumab is to be administered as an approximately 30-minute IV infusion (± 10 minutes). At the end of the infusion, flush the line with a sufficient quantity of normal saline or 5% dextrose solution.

When both study drugs are to be administered on the same day, separate infusion bags and filters must be used for each infusion. Nivolumab is to be administered first. The nivolumab infusion must be promptly followed by a saline flush to clear the line of nivolumab before starting the ipilimumab infusion. The second infusion will always be ipilimumab, and will start at least 30 minutes after completion of the nivolumab infusion.

The dosing calculations should be based on the body weight from Cycle 1 Day 1. If the subject's weight on the day of dosing differs by > 5% from the weight used to calculate the dose, the dose should be recalculated based on the current day of treatment weight. All doses should be rounded to the nearest milligram. There will be no dose modifications allowed.

Conditions

Mucosal Melanoma

Keywords

Ipilimumab; Nivolumab; OPDIVO; IgG4 kappa immunoglobulin

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Ipilimumab (1 mg/kg) + Nivolumab (3 mg/kg) IV

Cycles 1-4: Ipilimumab (1 mg/kg) + Nivolumab (3 mg/kg) IV Day 1 of each Cycle Each Cycle = 21 days

Cycles 5-15: Nivolumab IV 480 mg Day 1 of each Cycle Each Cycle = 28 days

Group Type: EXPERIMENTAL

Ipilimumab

Intervention Type: DRUG

1mg/kg

Nivolumab

Intervention Type: DRUG

3mg/kg

Nivolumab

Intervention Type: DRUG

480mg

Interventions

Ipilimumab

1mg/kg

Intervention Type: DRUG

Nivolumab

3mg/kg

Intervention Type: DRUG

Nivolumab

480mg

Intervention Type: DRUG

Other Intervention Names

Yervoy; BMS-734016; MDX010; OPDIVO; BMS-936558; ONO-4538; MDX1106; OPDIVO; BMS-936558; ONO-4538; MDX1106

Eligibility Criteria

Inclusion Criteria

• Histological confirmation of melanoma of any mucosal site including (but not limited to) anus/rectum, vulvar/vaginal, sinonasal. NOTE: Melanomas of cutaneous origin and/or ocular origin are ineligible.
• R0 or R1 resection of primary melanoma tumor (no gross disease can be left behind, but microscopically positive margins are acceptable).
• Surgery within ≤ 90 days of registration.
• ECOG Performance Status (PS) ≤ 1

The following laboratory values obtained ≤ 14 days prior to registration:

Hematological:

• Absolute Neutrophil Count (ANC) ≥ 1500/mm^3
• Hemoglobin (Hgb) ≥ 9 g/dL (may be transfused)
• Platelet (Plt) 100,000/mm^3

Renal:

• Serum Creatinine ≤ 1.5 x ULN

Hepatic:

• Alkaline Phosphatase (Alk Phos) ≤ 1.5 x upper limit of normal (ULN)
• Total and Direct Bilirubin ≤ 1.5 × (ULN)
• Aspartate aminotransferase (AST) ≤ 1.5 × ULN
• Negative pregnancy test done ≤ 7 days prior to registration, for women of childbearing potential only. NOTE: Females are considered of child bearing potential unless they are surgically sterile (have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are naturally postmenopausal for at least 12 consecutive months.
• Written informed consent and HIPAA authorization for release of personal health information prior to registration. NOTE: HIPAA authorization may be included in the informed consent or obtained separately.
• Willing to return to enrolling institution for follow-up
• Willing to provide archival tissue prior to C1D1 if available and blood samples for correlative research purposes

Exclusion Criteria

Subjects meeting any of the criteria below may not participate in the study:

• Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the subject inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.
• Immunocompromised patients and subjects known to be HIV positive and currently receiving antiretroviral therapy. NOTE: Subjects known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for this trial.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm.
• Other active malignancy ≤ 3 years prior to registration. EXCEPTIONS: Malignancies with a very low (< 5%) risk of recurrence such as non-melanotic skin cancer or carcinoma-in-situ of the cervix.
• History of myocardial infarction ≤ 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias.
• Active autoimmune disease -including but not limited to:

• Subjects with a history of inflammatory bowel disease, including ulcerative colitis and Crohn's Disease,
• Subjects with a history of symptomatic autoimmune disease requiring systemic treatment within the past 2 years with the use of disease modifying agents, corticosteroids, or immunosuppressive drugs.

• rheumatoid arthritis
• systemic progressive sclerosis (scleroderma)
• systemic lupus erythematosus
• psoriasis
• autoimmune vasculitis (e.g., Wegener's Granulomatosis)
• CNS or motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre Syndrome and Myasthenia Gravis, multiple sclerosis)

EXCEPTION: autoimmune conditions that are only requiring replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment.

• Any radiation within 2 weeks prior to study initiation. Neoadjuvant and adjuvant radiation are allowed, but must be completed > 2 weeks prior to registration.
• Any prior systemic therapy for melanoma (chemotherapy, immunotherapy, targeted therapy)
• Women of childbearing potential (WOCBP) must be willing to abstain from heterosexual intercourse or to use 2 forms of effective methods of contraception from the time of informed consent until 5 months after the last dose of study drug. The two contraception methods can be comprised of two barrier methods, or a barrier method plus a hormonal method. Examples include: intrauterine device (IUD), vasectomy of a female subject's male partner, contraceptive rod implanted into the skin, or use of two of the following: diaphragm with spermicide (cannot be used in conjunction with cervical cap/spermicide), cervical cap with spermicide (nulliparous women only), contraceptive sponge (nulliparous women only), male condom or female condom (cannot be used together), hormonal contraceptive.*Abstinence is acceptable if this is the usual lifestyle and preferred contraception for the subject. NOTE: Male subjects are not required to utilize contraception. The study regimen is not genotoxic and systemic concentrations sufficient to produce a risk of fetal toxicity are not expected in WOCBP partners from exposure to a male participant's seminal fluid.
• Pregnant or breastfeeding (NOTE: breast milk cannot be stored for future use while the mother is being treated on study).

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Bristol-Myers Squibb

INDUSTRY

Sponsor Role: collaborator

Hoosier Cancer Research Network

OTHER

Sponsor Role: collaborator

Robert R. McWilliams, MD

OTHER

Sponsor Role: lead

Responsible Party

Robert R. McWilliams, MD

Sponsor-Investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Robert R. McWilliams, MD

Role: STUDY_CHAIR

Hoosier Cancer Research Network

Locations

Mayo Clinic- Florida

Jacksonville, Florida, United States

University of Iowa Hospital and Clinics

Iowa City, Iowa, United States

University of Minnesota

Minneapolis, Minnesota, United States

Mayo Clinic Rochester

Rochester, Minnesota, United States

Nebraska Cancer Specialists

Omaha, Nebraska, United States

Providence Portland Medical Center

Portland, Oregon, United States

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

Countries

United States

Related Links

http://www.hoosiercancer.org

Hoosier Cancer Research Network Website

Other Identifiers

MEL16-252

Identifier Type: -

Identifier Source: org_study_id