Performance Evaluation by Magnetic Resonance Imaging (MRI) of Intramuscular Thigh Injections With 3 Configurations of Needle-free Injector (ZENEO®)

NCT ID: NCT03225638

Last Updated: 2017-07-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

86 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-01

Study Completion Date

2017-12-29

Brief Summary

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The aim of this study is to evaluate the intramuscular nominal thigh injection performance and the low threshold strength thigh injection (by evaluating 2 low threshold : upper limit and lower limit). All participants will receive an intramuscular nominal thigh injection, and half of the participants will receive an intramuscular low threshold (upper limit) strength thigh injection, while the other half will receive an intramuscular low threshold (lower limit) strength thigh injection.

Detailed Description

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Conditions

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No Condition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Group 1

Nominal strength thigh injection of 0.65ml of saline solution (0.9%) Low threshold (upper limit) strength thigh injection of 0.65ml of saline solution (0.9%)

Group Type OTHER

Intramuscular ZENEO® injection of nominal strength

Intervention Type COMBINATION_PRODUCT

Sodium Chloride (0.9%)

Intramuscular ZENEO® injection of low strength (upper limit)

Intervention Type COMBINATION_PRODUCT

Sodium Chloride (0.9%)

Group 2

Nominal strength thigh injection of 0.65ml of saline solution (0.9%) Low threshold (lower limit) strength thigh injection of 0.65ml of saline solution (0.9%)

Group Type OTHER

Intramuscular ZENEO® injection of nominal strength

Intervention Type COMBINATION_PRODUCT

Sodium Chloride (0.9%)

Intramuscular ZENEO® injection of low strength (lower limit)

Intervention Type COMBINATION_PRODUCT

Sodium Chloride (0.9%)

Interventions

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Intramuscular ZENEO® injection of nominal strength

Sodium Chloride (0.9%)

Intervention Type COMBINATION_PRODUCT

Intramuscular ZENEO® injection of low strength (upper limit)

Sodium Chloride (0.9%)

Intervention Type COMBINATION_PRODUCT

Intramuscular ZENEO® injection of low strength (lower limit)

Sodium Chloride (0.9%)

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* Male or female healthy volunteers aged between 18 and 60 years
* Affiliated to or covered by the French social security system
* BMI between ≥ 18 and \< 30 kg/m²
* Patients without chronic medical or surgical illness
* Patients with normal clinical examination at the screening visit
* Patients with normal blood pressure at the screening visit: systolic BP \< 140 mmHg and diastolic BP \< 90 mmHg, determined with the patient seated and resting for at least 5 minutes
* Patient within normal range values for the following laboratory tests (appendix I) unless the investigator considers an abnormality to be clinically irrelevant (to be documented and agreed with the sponsor before inclusion) within 1 month prior to the start of the study.
* Absence of cannabis, opiate, cocaine, amphetamine history
* Written Informed consent

Exclusion Criteria

* History of drug abuse
* History of hypersensitivity (disease or drug)
* Treatment with platelet inhibiting drugs within one week before inclusion
* Treatment with anticoagulant within four weeks before inclusion
* Subject likely to take any medication during the study
* Contra-indication to MRI: metallic intra-corporeal devices, claustrophobia
* Prior participation to other interventional clinical research within 3 months
* In custody due to administrative or legal decision or under tutelage or being admitted in a sanitary or social institution
* pregnant or breastfeeding woman
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Crossject

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Central Contacts

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CASTANO

Role: CONTACT

0380549852

Other Identifiers

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CJT-CS-2017-01

Identifier Type: -

Identifier Source: org_study_id

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