Trial Outcomes & Findings for Smoker-to-Smoker (S2S) Peer Marketing and Messaging to Disseminate Tobacco Interventions (NCT NCT03224520)
NCT ID: NCT03224520
Last Updated: 2021-03-26
Results Overview
Smoking cessation measured by the 7-day point prevalence question: Six month, 7-day point prevalence : Do you currently smoke cigarettes (smoked even 1 puff in the last 7 days)? * Yes * No * Don't know/not sure * Refused
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
1487 participants
Primary outcome timeframe
At 6 months post registration
Results posted on
2021-03-26
Participant Flow
Participant milestones
| Measure |
Fully Enhanced
Peer recruitment and recommender CTHC
Recommender CTHC: Enhanced Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Recommender CTHC Only
Recommender CTHC and standard online recruitment
Recommender CTHC: Enhanced Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
Peer Recruitment Only
Peer recruitment and standard CTHC
Standard CTHC: Standard Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Standard
Standard online recruitment and standard CTHC
Standard CTHC: Standard Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
|---|---|---|---|---|
|
Overall Study
STARTED
|
371
|
370
|
374
|
372
|
|
Overall Study
COMPLETED
|
205
|
207
|
190
|
199
|
|
Overall Study
NOT COMPLETED
|
166
|
163
|
184
|
173
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Smoker-to-Smoker (S2S) Peer Marketing and Messaging to Disseminate Tobacco Interventions
Baseline characteristics by cohort
| Measure |
Fully Enhanced
n=371 Participants
Peer recruitment and recommender CTHC
Recommender CTHC: Enhanced Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Recommender CTHC Only
n=370 Participants
Recommender CTHC and standard online recruitment
Recommender CTHC: Enhanced Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
Peer Recruitment Only
n=374 Participants
Peer recruitment and standard CTHC
Standard CTHC: Standard Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Standard
n=372 Participants
Standard online recruitment and standard CTHC
Standard CTHC: Standard Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
Total
n=1487 Participants
Total of all reporting groups
|
|---|---|---|---|---|---|
|
Race (NIH/OMB)
More than one race
|
11 Participants
n=5 Participants
|
12 Participants
n=7 Participants
|
16 Participants
n=5 Participants
|
15 Participants
n=4 Participants
|
54 Participants
n=21 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
13 Participants
n=5 Participants
|
16 Participants
n=7 Participants
|
20 Participants
n=5 Participants
|
16 Participants
n=4 Participants
|
65 Participants
n=21 Participants
|
|
Number of Cigarettes Smoked per day
0
|
14 Participants
n=5 Participants
|
12 Participants
n=7 Participants
|
18 Participants
n=5 Participants
|
16 Participants
n=4 Participants
|
60 Participants
n=21 Participants
|
|
Number of Cigarettes Smoked per day
>0 & <=10 Cigarettes
|
121 Participants
n=5 Participants
|
112 Participants
n=7 Participants
|
117 Participants
n=5 Participants
|
108 Participants
n=4 Participants
|
458 Participants
n=21 Participants
|
|
Age, Categorical
<=18 years
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=21 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
338 Participants
n=5 Participants
|
342 Participants
n=7 Participants
|
337 Participants
n=5 Participants
|
343 Participants
n=4 Participants
|
1360 Participants
n=21 Participants
|
|
Age, Categorical
>=65 years
|
33 Participants
n=5 Participants
|
28 Participants
n=7 Participants
|
37 Participants
n=5 Participants
|
29 Participants
n=4 Participants
|
127 Participants
n=21 Participants
|
|
Sex: Female, Male
Female
|
259 Participants
n=5 Participants
|
281 Participants
n=7 Participants
|
270 Participants
n=5 Participants
|
291 Participants
n=4 Participants
|
1101 Participants
n=21 Participants
|
|
Sex: Female, Male
Male
|
112 Participants
n=5 Participants
|
89 Participants
n=7 Participants
|
104 Participants
n=5 Participants
|
81 Participants
n=4 Participants
|
386 Participants
n=21 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
22 Participants
n=5 Participants
|
22 Participants
n=7 Participants
|
27 Participants
n=5 Participants
|
35 Participants
n=4 Participants
|
106 Participants
n=21 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
332 Participants
n=5 Participants
|
327 Participants
n=7 Participants
|
320 Participants
n=5 Participants
|
312 Participants
n=4 Participants
|
1291 Participants
n=21 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
17 Participants
n=5 Participants
|
21 Participants
n=7 Participants
|
27 Participants
n=5 Participants
|
25 Participants
n=4 Participants
|
90 Participants
n=21 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
1 Participants
n=5 Participants
|
2 Participants
n=7 Participants
|
4 Participants
n=5 Participants
|
5 Participants
n=4 Participants
|
12 Participants
n=21 Participants
|
|
Race (NIH/OMB)
Asian
|
6 Participants
n=5 Participants
|
5 Participants
n=7 Participants
|
7 Participants
n=5 Participants
|
7 Participants
n=4 Participants
|
25 Participants
n=21 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
2 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
2 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
4 Participants
n=21 Participants
|
|
Race (NIH/OMB)
Black or African American
|
43 Participants
n=5 Participants
|
42 Participants
n=7 Participants
|
37 Participants
n=5 Participants
|
38 Participants
n=4 Participants
|
160 Participants
n=21 Participants
|
|
Race (NIH/OMB)
White
|
295 Participants
n=5 Participants
|
293 Participants
n=7 Participants
|
288 Participants
n=5 Participants
|
291 Participants
n=4 Participants
|
1167 Participants
n=21 Participants
|
|
Number of Cigarettes Smoked per day
>10 & <=20 Cigarettes
|
171 Participants
n=5 Participants
|
163 Participants
n=7 Participants
|
167 Participants
n=5 Participants
|
162 Participants
n=4 Participants
|
663 Participants
n=21 Participants
|
|
Number of Cigarettes Smoked per day
>20 Cigarettes
|
65 Participants
n=5 Participants
|
83 Participants
n=7 Participants
|
72 Participants
n=5 Participants
|
86 Participants
n=4 Participants
|
306 Participants
n=21 Participants
|
|
Smoking Status
Already quit
|
48 Participants
n=5 Participants
|
56 Participants
n=7 Participants
|
61 Participants
n=5 Participants
|
67 Participants
n=4 Participants
|
232 Participants
n=21 Participants
|
|
Smoking Status
Thinking about quitting
|
303 Participants
n=5 Participants
|
299 Participants
n=7 Participants
|
294 Participants
n=5 Participants
|
286 Participants
n=4 Participants
|
1182 Participants
n=21 Participants
|
|
Smoking Status
Not thinking about quitting
|
17 Participants
n=5 Participants
|
10 Participants
n=7 Participants
|
17 Participants
n=5 Participants
|
18 Participants
n=4 Participants
|
62 Participants
n=21 Participants
|
|
Smoking Status
Missing
|
3 Participants
n=5 Participants
|
5 Participants
n=7 Participants
|
2 Participants
n=5 Participants
|
1 Participants
n=4 Participants
|
11 Participants
n=21 Participants
|
PRIMARY outcome
Timeframe: At 6 months post registrationSmoking cessation measured by the 7-day point prevalence question: Six month, 7-day point prevalence : Do you currently smoke cigarettes (smoked even 1 puff in the last 7 days)? * Yes * No * Don't know/not sure * Refused
Outcome measures
| Measure |
Fully Enhanced
n=205 Participants
Peer recruitment and recommender CTHC
Recommender CTHC: Enhanced Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Recommender CTHC Only
n=207 Participants
Recommender CTHC and standard online recruitment
Recommender CTHC: Enhanced Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
Peer Recruitment Only
n=190 Participants
Peer recruitment and standard CTHC
Standard CTHC: Standard Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Standard
n=199 Participants
Standard online recruitment and standard CTHC
Standard CTHC: Standard Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
|---|---|---|---|---|
|
Smoking Cessation
Smoked in the last 7 days
|
116 Participants
|
150 Participants
|
102 Participants
|
131 Participants
|
|
Smoking Cessation
Haven't smoked in last 7 days
|
89 Participants
|
57 Participants
|
88 Participants
|
68 Participants
|
SECONDARY outcome
Timeframe: At 6 months post registrationCalculated as: number of cigarettes smoked at six months minus the number of number of cigarettes smoked at baseline.
Outcome measures
| Measure |
Fully Enhanced
n=371 Participants
Peer recruitment and recommender CTHC
Recommender CTHC: Enhanced Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Recommender CTHC Only
n=370 Participants
Recommender CTHC and standard online recruitment
Recommender CTHC: Enhanced Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
Peer Recruitment Only
n=374 Participants
Peer recruitment and standard CTHC
Standard CTHC: Standard Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Standard
n=372 Participants
Standard online recruitment and standard CTHC
Standard CTHC: Standard Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
|---|---|---|---|---|
|
Change in the Number of Cigarettes Smoked
|
-9.60 cigarettes a day
Standard Deviation 10.81
|
-7.95 cigarettes a day
Standard Deviation 10.15
|
-10.63 cigarettes a day
Standard Deviation 9.99
|
-9.08 cigarettes a day
Standard Deviation 11.41
|
SECONDARY outcome
Timeframe: Throughout study (tracked for 6 months post registration)Population: Analysis population limited to participants who visited Decide2Quit more than one time.
As measured by, an ordinal scale of number of Decide2Quit functions used after the first DISC visit (0: no functions used; 1: use of 1-2 functions, 2: \> 2 functions used).
Outcome measures
| Measure |
Fully Enhanced
n=231 Participants
Peer recruitment and recommender CTHC
Recommender CTHC: Enhanced Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Recommender CTHC Only
n=228 Participants
Recommender CTHC and standard online recruitment
Recommender CTHC: Enhanced Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
Peer Recruitment Only
n=251 Participants
Peer recruitment and standard CTHC
Standard CTHC: Standard Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Standard
n=250 Participants
Standard online recruitment and standard CTHC
Standard CTHC: Standard Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
|---|---|---|---|---|
|
Repeated Use of Decide2Quit Functions
No Use
|
173 Participants
|
159 Participants
|
171 Participants
|
157 Participants
|
|
Repeated Use of Decide2Quit Functions
1 or 2 Functions Used
|
24 Participants
|
24 Participants
|
26 Participants
|
34 Participants
|
|
Repeated Use of Decide2Quit Functions
Greater than 2 Functions Used
|
34 Participants
|
45 Participants
|
54 Participants
|
59 Participants
|
SECONDARY outcome
Timeframe: At Baseline RegistrationThis is measured by the proportion of African Americans in each treatment arm
Outcome measures
| Measure |
Fully Enhanced
n=371 Participants
Peer recruitment and recommender CTHC
Recommender CTHC: Enhanced Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Recommender CTHC Only
n=370 Participants
Recommender CTHC and standard online recruitment
Recommender CTHC: Enhanced Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
Peer Recruitment Only
n=374 Participants
Peer recruitment and standard CTHC
Standard CTHC: Standard Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Standard
n=372 Participants
Standard online recruitment and standard CTHC
Standard CTHC: Standard Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
|---|---|---|---|---|
|
Recruitment of African Americans
|
49 Participants
|
49 Participants
|
47 Participants
|
44 Participants
|
SECONDARY outcome
Timeframe: At Baseline RegistrationCalculated as: each individual participant's recruitment date minus the date of the first participant's registration. Based on this formula, the first participant will have a recruitment time of 0 days and the last participant could have a maximum recruitment time of 3 years (1095 days).
Outcome measures
| Measure |
Fully Enhanced
n=371 Participants
Peer recruitment and recommender CTHC
Recommender CTHC: Enhanced Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Recommender CTHC Only
n=369 Participants
Recommender CTHC and standard online recruitment
Recommender CTHC: Enhanced Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
Peer Recruitment Only
n=373 Participants
Peer recruitment and standard CTHC
Standard CTHC: Standard Messaging
Peer Recruitment: Tools to facilitate smokers' recruiting their peers
|
Standard
n=371 Participants
Standard online recruitment and standard CTHC
Standard CTHC: Standard Messaging
Standard Online Recruitment: Search Engine and Social Media Advertisements
|
|---|---|---|---|---|
|
Recruitment Time
|
377.22 days
Standard Deviation 135.80
|
379.29 days
Standard Deviation 133.32
|
383.98 days
Standard Deviation 136.84
|
367.28 days
Standard Deviation 134.17
|
Adverse Events
Fully Enhanced
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Recommender CTHC Only
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Peer Recruitment Only
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Standard
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Rajani Sadasivam
University of Massachusetts Medical School
Phone: 508-856-8923
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place