Serum AMH Levels in Patients Who Underwent Hypogastric Artery Ligation

NCT ID: NCT03220594

Last Updated: 2017-10-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-03-20

Study Completion Date

2017-09-29

Brief Summary

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To observe the effects of hypogastric artery ligation on serum antimullerian hormone levels.

Detailed Description

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To measure and compare serum antimullerian hormone levels in patients who underwent hypogastric artery ligation/ hypogastric artery ligation+ hysterectomy and postpartum control. The procedures performed as an emergency life saving method during delivery. The reasons for hypogastric artery ligation/ hypogastric artery ligation+ hysterectomy were obstetric hemorrhage mainly uterine atony.

The serum levels of antimullerian hormone were measured 6 months after the operations and compared with matching postpartum controls. Serum levels of FSH, LH, PRL and TSH were also measured 6 months after the operation. Further, antral follicle count measured along with the aforementioned blood tests.

Conditions

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AMH

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Hypogastric artery ligation (HAL)

Patients who underwent only hypogastric artery ligation performed during the delivery of their babies. Six months after the operation they will evaluated for their ovarian reserve via hormones and astral follicle count (AFC)

hypogastric artery ligation

Intervention Type PROCEDURE

hypogastric artery ligation is the ligation of the internal iliac artery to stop bleeding related to obstetrics obstetric hemorrhage Hysterectomy is the removal of the uterus if bleeding can't stop by hypogastric artery ligation

HAL and hysterectomy

Patients who underwent both hypogastric artery ligation and hysterectomy performed during the delivery of their babies. Six months after the operation they will evaluated for their ovarian reserve via hormones and astral follicle count (AFC)

hypogastric artery ligation

Intervention Type PROCEDURE

hypogastric artery ligation is the ligation of the internal iliac artery to stop bleeding related to obstetrics obstetric hemorrhage Hysterectomy is the removal of the uterus if bleeding can't stop by hypogastric artery ligation

Postpartum

Postpartum control group constituted of patients delivered baby without any complication and evaluated 6 months later.

No interventions assigned to this group

Interventions

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hypogastric artery ligation

hypogastric artery ligation is the ligation of the internal iliac artery to stop bleeding related to obstetrics obstetric hemorrhage Hysterectomy is the removal of the uterus if bleeding can't stop by hypogastric artery ligation

Intervention Type PROCEDURE

Other Intervention Names

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hysterectomy

Eligibility Criteria

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Inclusion Criteria

* age 18- 40 years
* no systemic or endocrine diseases
* patients who had hypogastric artery ligation and/or hysterectomy
* healthy postpartum patients as controls

Exclusion Criteria

* history of chemotherapy and/or radiotherapy
* Obese patients
* patients with previous/present endometriosis
* patients with PCOS
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Kanuni Sultan Suleyman Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Berna Aslan Cetin

MD,ObGYN

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alev Atıs, MD,ObGyn

Role: STUDY_DIRECTOR

Kanuni Sultan Suleyman Training and Research Hospital

Locations

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Kanuni SSTRH

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Related Links

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https://www.ncbi.nlm.nih.gov/pubmed/22268398

The effect of total abdominal hysterectomy on serum anti-Müllerian hormone levels: a pilot study

https://www.ncbi.nlm.nih.gov/pubmed/20128664

Effect of internal iliac artery ligation on ovarian blood supply and ovarian reserve

Other Identifiers

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1826

Identifier Type: -

Identifier Source: org_study_id