Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer
NCT ID: NCT03213769
Last Updated: 2017-07-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
52 participants
INTERVENTIONAL
2017-07-31
2018-07-31
Brief Summary
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Detailed Description
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Sample size of study include 26 in each group.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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topical coenzyme Q10 gel
Q10 gel will give 2 times /day after breakfast and evening meal for 7 days.
topical coenzyme Q10 gel
Q10 gel will give 2 times /day after breakfast and evening meal for 7 days.
carbapol gel
placebo carbapol gel will give 2 times /day after breakfast and evening meal for 7 days.
Carpabol gel
placebo carbapol gel will give 2 times /day after breakfast and evening meal for 7 days.
Interventions
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topical coenzyme Q10 gel
Q10 gel will give 2 times /day after breakfast and evening meal for 7 days.
Carpabol gel
placebo carbapol gel will give 2 times /day after breakfast and evening meal for 7 days.
Eligibility Criteria
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Inclusion Criteria
* Patients clinically diagnosed as suffering from symptomatic oral minor aphthous ulcers.
* Patients who agreed to take medications.
Exclusion Criteria
* Anemic and leukemic patients (using complete blood count investigation)
* Patients taking systemic drugs such as systemic steroids and other immunosuppressive therapy.
* Patients treated with any oral topical medications 48h before the study27.
* Pregnant and lactating mothers.
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Mostafa Abdelsamie Bakry Nafie
Principal investigator
Principal Investigators
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fatheya zahran, professor
Role: STUDY_DIRECTOR
faculty of dentistry -CairoU
Central Contacts
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References
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Sawair FA. Recurrent aphthous stomatitis: do we know what patients are using to treat the ulcers? J Altern Complement Med. 2010 Jun;16(6):651-5. doi: 10.1089/acm.2009.0555.
Scully C, Felix DH. Oral medicine--update for the dental practitioner. Aphthous and other common ulcers. Br Dent J. 2005 Sep 10;199(5):259-64. doi: 10.1038/sj.bdj.4812649.
Momen-Beitollahi J, Mansourian A, Momen-Heravi F, Amanlou M, Obradov S, Sahebjamee M. Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis. Med Oral Patol Oral Cir Bucal. 2010 Jul 1;15(4):e557-61. doi: 10.4317/medoral.15.e557.
Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007 Sep;37(1):31-7. doi: 10.1007/s12033-007-0052-y.
Tarakji B, Gazal G, Al-Maweri SA, Azzeghaiby SN, Alaizari N. Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners. J Int Oral Health. 2015 May;7(5):74-80.
Prakash S, Sunitha J, Hans M. Role of coenzyme Q(10) as an antioxidant and bioenergizer in periodontal diseases. Indian J Pharmacol. 2010 Dec;42(6):334-7. doi: 10.4103/0253-7613.71884.
Preeti L, Magesh K, Rajkumar K, Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011 Sep;15(3):252-6. doi: 10.4103/0973-029X.86669.
Hamdy AA, Ibrahem MA. Management of aphthous ulceration with topical quercetin: a randomized clinical trial. J Contemp Dent Pract. 2010 Jul 1;11(4):E009-16.
Other Identifiers
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1990
Identifier Type: -
Identifier Source: org_study_id
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