Blood Ammonia as Predictor for Esophageal Varices and Risk of Bleeding
NCT ID: NCT03212872
Last Updated: 2017-07-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
150 participants
INTERVENTIONAL
2016-07-07
2018-12-31
Brief Summary
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Detailed Description
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Patient groups groups:
Group (1): 100 patients with esophageal varices
Group (2): 50 chronic liver disease patients with no esophageal varices as a control group.
All patients will be subjected to:
1. \- Detailed history-taking
2. \- Full clinical examination
3. \- Laboratory investigations:
* Complete blood picture (CBC)
* Erythrocyte sedimentation rate (ESR)
* Renal function tests
* Liver function tests
* Prothrombin time and activity
* Viral markers (HCV Ab - HBV Ag)
* Blood ammonia level.
4. \- Pelviabdominal US: Ultrasound examination of the liver, portal venous system, spleen, kidney and other abdominal organs.
5. \- Upper GITendoscopy:
* Varices will be classified according to the Japanese classification 1996,
* The Baveno 11 score will be used to differentiate between mild and severe portal hypertensive gastropathy.
Conditions
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Study Design
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NA
SINGLE_GROUP
SCREENING
NONE
Study Groups
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Endoscopy
Endoscopy
Interventions
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Endoscopy
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patient in active bleeding or with history of bleeding within the two weeks prior to entry in the study .
* Patients with heart failure.
* Patients with renal failure.
* Patient with hepatocellular carcinoma and portal vein thrombosis.
* Patient taking Beta blockers.
18 Years
ALL
No
Sponsors
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Tanta University
OTHER
Responsible Party
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Ferial El-Kalla
Professor
Principal Investigators
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Ferial El-Kalla, MD
Role: PRINCIPAL_INVESTIGATOR
Tanta University
Locations
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Tanta Faculty of Medicine
Tanta, Gharbiah, Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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30142/03/31
Identifier Type: -
Identifier Source: org_study_id
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