Melatonin Decreases Eye Pressure in Normotensive Patients

NCT ID: NCT03193112

Last Updated: 2018-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-16

Study Completion Date

2018-06-15

Brief Summary

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Agomelatine is a melatonin drug used to treat depressive disorder. Agomelatine may also some effects on ocular pressures. In this study, we aimed to demonstrate that melatonin decreases intraocular pressures when given depressive patients.

Detailed Description

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Melatonin has been shown to be effective to decrease intraocular pressure in experimental animal researches. Agomelatine is a melatonin derivative drug approved for the treatment of depression, which is also available in our country. Depending on animal experiments, it can be assumed that agomelatine can decrease intraocular pressure. Demonstrating that agomelatine is effective to reduce eye pressure may give a concurrent treatment of depressive patients with glaucoma. With this it may be possible to treat both diseases at the same time with single drug. In this study, the researchers intended to investigate the changes in ocular tension in normotensive depressive patients treated with agomelatine.

Conditions

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Depressive Disorder

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Study group

The investigators analyze the intraocular pressure changes on patients who have been using Agomelatine for their primary depressive disorder. For the treatment of depression, patients will have been started routinely Agomelatine tablet of 25 mg orally. The investigators measure the eye pressure for one months in those patients receiving standard depression treatment.

Agomelatine 25 MG Oral Tablet

Intervention Type DRUG

We will treat our patients with Agomelatine tablet of 25 mg.

Interventions

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Agomelatine 25 MG Oral Tablet

We will treat our patients with Agomelatine tablet of 25 mg.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Depressive patients suitable for Agomelatine therapy for the treatment of their primary disease.

Exclusion Criteria

\- Any past history of ocular surgery, ocular trauma or existing ocular diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

66 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kahramanmaras Sutcu Imam University

OTHER

Sponsor Role lead

Responsible Party

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Gokhan Ozdemir

Principal investigator, Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gokhan Ozdemir, MD

Role: PRINCIPAL_INVESTIGATOR

KSU

Locations

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Kahramanmaras Sutcuimam University Ophthalmology Department

Kahramanmaraş, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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KahramanmarasSIU

Identifier Type: -

Identifier Source: org_study_id

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