Apatinib as Second Line Therapy in Patients With Advanced Refractory Biliary Tract Cancers

NCT ID: NCT03144856

Last Updated: 2017-05-09

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 39 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-02-22
• Study Completion Date: 2019-03-01

Brief Summary

This study is designed to see whether Apatinib is effective in treating patients with advanced refractory biliary tract cancers.

Detailed Description

Biliary tract cancers (BTC) includes cholangiocarcinoma and gallbladder carcinoma (GBC). The systematic treatment based on gemcitabine plus cisplatin is recommended as the current standard chemotherapy for unresectable or metastatic BTC. There is no standard recommendation for second line therapy.

Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2).

This study was conducted to assess the efficacy and safety of Apatinib in patients with advanced refractory BTC who had received first-line chemotherapy.

Conditions

Biliary Tract Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Apatinib group

Apatinib 500mg, po, QD, every 4 weeks.

Group Type: EXPERIMENTAL

Apatinib

Intervention Type: DRUG

Apatinib 500mg, po, qd, every 4 weeks.

Interventions

Apatinib

Apatinib 500mg, po, qd, every 4 weeks.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Must have histologically or cytologically documented carcinoma primary to the intra- or extra-hepatic biliary system or gall bladder with clinical and/or radiologic evidence of unresectable, locally advanced or metastatic disease.

2. Patients with ampullary carcinoma are not eligible.

3. Must have failed or are intolerant to one line of systemic treatment but no more than 2 prior lines of systemic chemotherapy for advanced BTC. Patients who received adjuvant chemotherapy and had evidence of disease recurrence within 6 months of completion of the adjuvant treatment are also eligible. If the patient received adjuvant treatment and had disease recurrence after 6 months, patients will only be eligible after failing or having intolerance to one line of systemic chemotherapy used to treat the disease recurrence.

4. Age between 18 and 75 years old

5. Eastern Cooperative Oncology Group (ECOG) Performance Status Assessment of 0 or 1.

6. Must have radiographic measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.

7. Life expectancy of at least 12 weeks (3 months).

8. For patients who have received prior radiation, cryotherapy, radiofrequency ablation, therasphere, ethanol injection, transarterial chemoembolization (TACE) or photodynamic therapy, the following criteria must be met: 28 days have elapsed since that therapy; Lesions that have not been treated with local therapy must be present and measureable.

9. Must be able to understand and be willing to sign the written informed consent form. Must be willing and able to comply with scheduled visits, treatment schedule, laboratory testing, and other study requirements.

10. All acute toxic effects of any prior treatment have resolved to NCI-CTCAE v4.0 Grade 1 or less at the time of signing the Informed Consent Form (ICF) except for alopecia.

11. Adequate bone marrow, liver and liver function.

12. Women of childbearing potential must have a negative serum pregnancy test performed within 7 days prior to the start of study drug.

13. Men and women of childbearing potential must agree to use adequate contraception beginning at the signing of the ICF until at least 3 months after the last dose of study drug.

Exclusion Criteria

1. Pregnant or lactating women;

2. History of other malignancies except cured basal cell carcinoma of skin and carcinoma insitu of uterine cervix;

3. Uncontrolled hypertension;

4. Intercurrence with one of the following: coronary artery disease, arrhythmia and heart failure;

5. Urine protein>grade 1;

6. Any factors that influence the usage of oral administration;

7. Patients with a clear tendency of gastrointestinal bleeding;

8. Abnormal coagulation function(INR≥1.5, APTT≥1.5 ULN);

9. Abuse of alcohol or drugs;

10. Less than 4 weeks from the last clinical trial;

11. Prior treatment with antivascular endothelial growth factor or the other anti angiogenesis therapy;

12. Active central nervous system (CNS). If CNS metastases are treated and potential participants are at neurologic baseline for at least 2 weeks prior to enrollment, they will be eligible but will need a Brain MRI prior to enrollment. 13. Disability of serious uncontrolled intercurrence infection.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Jiangsu HengRui Medicine Co., Ltd.

INDUSTRY

Sponsor Role: collaborator

Sun Yat-sen University

OTHER

Sponsor Role: lead

Responsible Party

Fenghua Wang

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Rui-Hua Xu, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Sun Yat-sen University

Locations

Foshan people's Hospital

Foshan, Guangdong, China

Site Status: RECRUITING

Cancer center of Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status: RECRUITING

Countries

China

Central Contacts

Feng-Hua Wang, MD, PhD

Role: CONTACT

wangfh@sysucc.org.cn

86-020-87342490

Facility Contacts

Wei Wang

Role: primary

m18038863618@163.com

075783161035

Fenghua Wang, MD, PhD

Role: primary

wangfh@sysucc.org.cn

86-020-87342490

Miao-Zhen Qiu, MD, PhD

Role: backup

qiumzh@sysucc.org.cn

86-020-87342490

Other Identifiers

Apatinib_BTC

Identifier Type: -

Identifier Source: org_study_id