Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid

NCT ID: NCT03143023

Last Updated: 2017-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-06-30

Study Completion Date

2018-02-28

Brief Summary

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This study will be conducted to evaluate the effect of arginine versus fluoride containing toothpaste on neutralization of microbial acid produced by Cariogenic bacteria in adult population using chair side assessment method.

Detailed Description

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.28 volunteer participants will be assigned in this study. Participants will be randomly divided into two groups(n=14) according to type of toothpaste D where groups D1 patient will use arginine containing toothpaste while groups D2 the patient will used the fluoride toothpaste with a number of 14 patients in each group. The pH will be evaluated according to time in relation to the brushing with toothpaste (T) where (T0) represent salivary pH before brushing with toothpaste , (T1) represent salivary pH 10 minutes after brushing with toothpaste at fixed time of the day.

Conditions

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Dental Caries

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Caregivers Outcome Assessors

Study Groups

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arginine toothpaste

Group Type EXPERIMENTAL

arginine toothpaste

Intervention Type DRUG

acid neutralizer toothpaste

fluoride toothpaste

Group Type ACTIVE_COMPARATOR

fluoride toothpaste

Intervention Type DRUG

bactericidal toothpaste

Interventions

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arginine toothpaste

acid neutralizer toothpaste

Intervention Type DRUG

fluoride toothpaste

bactericidal toothpaste

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Participants should be over 18 years of age.
* Systematically healthy.
* Not taking any medication interfering with saliva secretion.
* Participants who signed informed consent.

Exclusion Criteria

* Participants with a compromised medical history.
* Participants under systemic disease treatment, with antibiotic, steroid or any medication known to cause dry mouth.
* Severe or active periodontal disease.
* History of allergies or other adverse reactions to arginine, or oral care product or their ingredient.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Laura Yehia

Resident of conservative departement , Faculty of Oral and Dental Medicine, Cairo university,2013

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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laura yehia zanati, master

Role: CONTACT

01204470007

aya mohamed adly, master

Role: CONTACT

012215228843

Other Identifiers

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CEBC-CU-2017-04-18

Identifier Type: -

Identifier Source: org_study_id

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