TEE as a Guide for Fluid Optimization in Major Abdominal Oncosurgery
NCT ID: NCT03140540
Last Updated: 2020-10-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2019-02-16
2020-02-27
Brief Summary
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Lactate levels as a surrogate indicator of organ perfusion as measured by arterial blood gas analysis intraoperatively, after 12 hours and 48 hrs postoperatively
Detailed Description
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GDT (goal directed therapy): continuous infusion of crystalloids 2 mL/kg/h.
If (velocity time integral) VTI \<20, 250 mL colloid bolus administered. Dose repeated every 10 min until goal of VTI \>20 met. Norepinephrine titrated to maintain MAP(mean arterial pressure) \> 65 mm Hg. Blood transfused for haemoglobin \<8 g Lactate levels as a surrogate indicator of organ perfusion as measured by arterial blood gas analysis at time of incision intraoperatively and after 12 hours and 48 hrs. The incidence of postoperative complications, morbidity, mortality, duration of mechanical ventilation and ICU stay.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
SINGLE
Study Groups
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Group A (stroke volume variation) guided fluid
Stroke volume variation guided intraoperative intravenous fluid will be administered.
Stroke volume variation guided intravenous fluid.
Active Comparator: Group A control group (SVV guided fluid ) Stroke volume variation guided intraoperative intravenous fluid will be administered. SVV \>10, 200 ml of colloid bolus to be given
Group B(Study group) TEE guided fluid
Transesophageal echocardiography will be used to guide the fluid therapy.
TEE guided fluid therapy will be administered
Transesophageal echocardiography will be used to guide the fluid therapy. Velocity time integral of aorta \<20 ,200ml colloid bolus to be administered.
Interventions
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TEE guided fluid therapy will be administered
Transesophageal echocardiography will be used to guide the fluid therapy. Velocity time integral of aorta \<20 ,200ml colloid bolus to be administered.
Stroke volume variation guided intravenous fluid.
Active Comparator: Group A control group (SVV guided fluid ) Stroke volume variation guided intraoperative intravenous fluid will be administered. SVV \>10, 200 ml of colloid bolus to be given
Eligibility Criteria
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Inclusion Criteria
* Undergoing major abdominal oncosurgery
Exclusion Criteria
18 Years
80 Years
ALL
No
Sponsors
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Rajiv Gandhi Cancer Institute & Research Center, India
OTHER
Responsible Party
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Dr soumi pathak
Principal Investigator
Locations
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Rajiv Gandhi Cancer Institute
Delhi, , India
Countries
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References
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Guarracino F. [The role of transesophageal echocardiography in intraoperative hemodynamic monitoring]. Minerva Anestesiol. 2001 Apr;67(4):320-4. Italian.
Trinooson CD, Gold ME. Impact of goal-directed perioperative fluid management in high-risk surgical procedures: a literature review. AANA J. 2013 Oct;81(5):357-68.
Other Identifiers
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RGCI ID:500/AN/ANK-02
Identifier Type: -
Identifier Source: org_study_id