Optimization of Remotely Delivered Physical Activity Intervention for Breast Cancer Survivors

NCT ID: NCT03131440

Last Updated: 2023-03-10

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

280 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-24

Study Completion Date

2019-06-17

Brief Summary

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The overall objective of the proposed research is to pilot test the feasibility and acceptability of a set of more scalable technology-supported physical activity promotion intervention strategies in breast cancer survivors using tMultiphase Optimization Strategy Trial (MOST) methodology. MOST involves highly efficient randomized experimentation to assess the effects of individual intervention strategies, and thereby identify which strategies and what strategy levels make the important contributions to the overall program's effect on physical activity. This information then guides assembly of an optimized physical activity program, that achieves target outcomes with least resource consumption and participant burden. The resulting intervention will have great potential for scalability because it uses technology (smartphones) participants already own and requires no on-site visits.

Detailed Description

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Conditions

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Breast Cancer Female Physical Activity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants

Study Groups

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Experimental Condition #1

core, support calls

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

Experimental Condition #2

core, support calls, app+

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Experimental Condition #3

core, support calls, buddy

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #4

core, support calls, online gym

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

Experimental Condition #5

core, support calls, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Experimental Condition #6

core, app+

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Experimental Condition #7

core, app+, buddy

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #8

core, app+, online gym

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

Experimental Condition #9

core, app+, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Experimental Condition #10

core, buddy

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #11

core, buddy, online gym

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #12

core, buddy, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #13

core, online gym

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

Experimental Condition #14

core, online gym, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Experimental Condition #15

core, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Experimental Condition #16

core, support calls, app+, buddy

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #17

core, support calls, app+, online gym

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

Experimental Condition #18

core, support calls, app+, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Experimental Condition #19

core, support calls, buddy, online gym

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #20

core, support calls, buddy, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #21

core, support calls, online gym, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Experimental Condition #22

core, app+, buddy, online gym

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #23

core, app+, buddy, online gym, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #24

core, support calls, buddy, online gym, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #25

core, buddy, online gym, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #26

core, app+, online gym, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Experimental Condition #27

core, support calls, app+, buddy, online gym

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #28

core, support calls, app+, buddy, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #29

core, support calls, app+, online gym, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Experimental Condition #30

core

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Experimental Condition #31

core, app+, buddy, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Experimental Condition #32

core, support calls, app+, buddy, online gym, app notifications

Group Type EXPERIMENTAL

Core

Intervention Type BEHAVIORAL

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Support Calls

Intervention Type BEHAVIORAL

Participants will receive 6 bi-weekly phone calls from study staff.

App+

Intervention Type BEHAVIORAL

Participants will receive "deluxe" version of smartphone app with additional features.

Online gym

Intervention Type BEHAVIORAL

Participants will receive access to online exercise videos.

App notifications

Intervention Type BEHAVIORAL

Participants will receive motivational app notifications

Buddy

Intervention Type BEHAVIORAL

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Interventions

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Core

The core intervention will include educational materials, access to a basic smartphone app and a Fitbit.

Intervention Type BEHAVIORAL

Support Calls

Participants will receive 6 bi-weekly phone calls from study staff.

Intervention Type BEHAVIORAL

App+

Participants will receive "deluxe" version of smartphone app with additional features.

Intervention Type BEHAVIORAL

Online gym

Participants will receive access to online exercise videos.

Intervention Type BEHAVIORAL

App notifications

Participants will receive motivational app notifications

Intervention Type BEHAVIORAL

Buddy

Participants will choose a buddy to receive a Fitbit and support them during the intervention.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Diagnosed with Stage I-III breast cancer within the last 5 years
2. Have completed last cancer treatment (adjuvant chemotherapy, radiation therapy or surgery) at least 3 months prior to enrollment
3. English speaking
4. Currently participate in less than 60 minutes of moderate and vigorous physical activity per week
5. Own a smartphone
6. Have access to a computer with Internet
7. Participants may be using adjuvant endocrine therapies.
8. Willing to be waitlisted for future wave if current wave reaches capacity

Exclusion Criteria

-Women will be excluded if they report any of the following:

1. Respiratory, joint or cardiovascular problems precluding physical activity
2. Metastatic disease
3. Planned elective surgery during duration of the intervention/follow-up that would interfere with participation (e.g., breast reconstructive surgery).

ONLY IF PARTICIPATING IN OPTIONAL BLOOD COLLECTION:

1. A prior cardiovascular event (i.e. stroke, myocardial infarction)
2. Have been diagnosed with an acute or chronic immune system medical conditions, or conditions that impact immune and endocrine function (e.g., CFS, Lupus, rheumatoid arthritis, Hepatitis C, or immunosuppressive treatment requiring conditions)
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Northwestern University

OTHER

Sponsor Role lead

Responsible Party

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Siobhan M Phillips

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Northwestern University

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Solk P, Song J, Reading J, Starikovsky J, Cullather E, Wang S, Hasanaj K, Morelli WA, Spring B, Cella D, Penedo F, Ackermann R, Courneya KS, Siddique J, Frey J, Phillips SM. Feasibility and acceptability of the Fit2Thrive mHealth physical activity promotion intervention components in breast cancer survivors. Transl Behav Med. 2025 Jan 16;15(1):ibaf033. doi: 10.1093/tbm/ibaf033.

Reference Type DERIVED
PMID: 40795071 (View on PubMed)

Solk P, Song J, Welch WA, Spring B, Cella D, Penedo F, Ackermann R, Courneya KS, Siddique J, Freeman H, Starikovsky J, Mishory A, Alexander J, Wolter M, Carden L, Phillips SM. Effect of the Fit2Thrive Intervention on Patient-reported Outcomes in Breast Cancer Survivors: A Randomized Full Factorial Trial. Ann Behav Med. 2023 Aug 21;57(9):765-776. doi: 10.1093/abm/kaad024.

Reference Type DERIVED
PMID: 37203237 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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K07CA196840

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R21CA219028-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

K07CA196840

Identifier Type: NIH

Identifier Source: org_study_id

View Link

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