ProF-001_Phase IIa

NCT ID: NCT03115073

Last Updated: 2019-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-04

Study Completion Date

2018-07-30

Brief Summary

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This is a multi-center, randomized, prospective, active-controlled, double-blind, dose-escalation study comparing dose response of clinical efficacy, safety, local tolerability of three different doses of ProF-001/Candiplus® (Candiplus® 0.2%, Candiplus® with 0.3%, Candiplus® with 0.4%) to 1% clotrimazole vaginal cream.

Patients with acute episode of vulvovaginal candidiasis (VVC) will be randomized to receive a daily dose of either 5 ml (intravaginal) of Candiplus® at three different doses for the first 3 days and 2.5 ml for the remaining 3 days or 5 ml (intravaginal) application of 1% clotrimazole cream over the first 3 days and 2.5 ml for the remaining 3 days according to the following scheme (with each application 2 cm of cream will be applied to the vulvar region):

Cohort 1: Candiplus® 0.2% versus clotrimazole mono Cohort 2: Candiplus® 0.3% versus clotrimazole mono Cohort 3: Candiplus® 0.4% versus clotrimazole mono Randomization into the cohorts will occur consecutively from the lowest dose to the highest dose, i.e. patients will be randomized first in cohort 1 and finally in cohort 3.

The proposed study is - after a pilot study to assess critical pharmacokinetic data - the second study within a clinical trial program with the objective to develop a new combination therapy for the treatment of vulvovaginal candidiasis.

The new combination consists of two registered drug substances.

Detailed Description

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Conditions

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Vulvovaginal Candidiasis (VVC)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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0,2% Candiplus

Candiplus® 0.2%

Group Type EXPERIMENTAL

Candiplus

Intervention Type DRUG

Administration of Candiplus

0,3% Candiplus

Candiplus® 0.3%

Group Type EXPERIMENTAL

Candiplus

Intervention Type DRUG

Administration of Candiplus

0,4% Candiplus

Candiplus® 0.4%

Group Type EXPERIMENTAL

Candiplus

Intervention Type DRUG

Administration of Candiplus

Clotri mono

Clotrimazole mono

Group Type ACTIVE_COMPARATOR

Clotrimazole

Intervention Type DRUG

Administration of Clotrimazole

Interventions

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Candiplus

Administration of Candiplus

Intervention Type DRUG

Clotrimazole

Administration of Clotrimazole

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Premenopausal female patients ≥ 18 years old
* Patients suffering from an acute episode of vulvovaginal candidiasis, characterized by:

* Positive vaginal smear (native, KOH) for budding yeasts and/or fungal (pseudo-) hyphae, normal or intermediate flora (G I and G II)
* Positive clinical symptoms (itching, burning, irritation, edema, erythema, excoriations), with a subjective symptom score of at least 3 (0=absent, 1=mild, 2=moderate, and 3=severe), with score being at least moderate for at least 1 subjective symptom and itching being present, and a total sign and symptom score of at least 4
* Readiness for sexual abstinence from start of treatment until test of cure (TOC) - visit
* Sufficient knowledge of German language to understand trial instructions and rating scales, and ability to comply with treatment
* Written informed consent prior to enrolment

Exclusion Criteria

* Known hypersensitivity to any ingredient of the investigational medicinal product
* Pregnancy or breast feeding at time of screening
* Menstrual bleeding (spotting is not an exclusion criterion) during the first three days of treatment
* Acute cystitis
* Patients with clinical signs of other infectious causes of vulvovaginitis: bacterial vaginosis (GIII), trichomonas vaginalis, herpes simplex genitalis
* Treatment with antimycotics (systemic or vaginal) within 7 days of randomization
* Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs)
* Patients with other clinical gynecological abnormalities, such as infections of the upper urogenital tract (pelvic inflammatory disease, adnexitis)
* Subjects with another vaginal or vulvar condition that would confound the interpretation of clinical response (e.g. Lichen sclerosus, neuropathic pain)
* Subjects who will be under treatment or surgery for gynecological pathologies during the study period, i.e, cervical intraepithelial neoplasia, cervical carcinoma, other neoplasms
* Known alcohol, drug or medication abuse
* Any clinically relevant concomitant condition that could compromise the objectives of this study and/ or the patient's compliance (eg. known immune deficiency syndrome with clinical relevance at time of screening)
* Participation in another interventional clinical trial within the last 30 days
* Employee at the study site, spouse/partner or relative of any study staff (e.g., investigator, sub-investigators, or study nurse) or relationship to the sponsor
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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ProFem GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Herbert Kiss, Ao.Univ.Prof.Dr.

Role: PRINCIPAL_INVESTIGATOR

Medical University of Vienna

Locations

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Medical University Innsbruck

Innsbruck, , Austria

Site Status

Bezirkskrankenhaus Schwaz

Schwaz, , Austria

Site Status

Medical University Vienna

Vienna, , Austria

Site Status

Countries

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Austria

References

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Schaller M, Mailhammer R, Korting HC. Cytokine expression induced by Candida albicans in a model of cutaneous candidosis based on reconstituted human epidermis. J Med Microbiol. 2002 Aug;51(8):672-676. doi: 10.1099/0022-1317-51-8-672.

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Related Links

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http://archives.who.int/eml/expcom/expcom14/clotrimazole/clotrimazole_ECP_review_16feb05.pdf

Lisa A. Bero, February 15, 2005, Expert Committee on Selection and Use of Essential Medicines, Review of Application of Clotrimazole for topical or intravaginal use in vulvovaginal candidiasis.

http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM509411.pdf

FDA draft Guidance for Industry Vulvovaginal Candidiasis -Developing Drugs for Treatment, 2016.

https://pdfs.semanticscholar.org/370b/92bc4f61fedfa64e1b50e7a10c7a6dde0a19.pdf

Newcombe, R.G. "Interval estimation for the difference between independent proportions: comparison of eleven methods" Statistics in Medicine 17(1988) pp. 873-890

http://mic.microbiologyresearch.org/content/journal/micro/10.1099/13500872-140-11-2971

Santoni G, Gismondi A, Liu JH, et al. Candida albicans expresses a fibronectin receptor antigenically related to a5b1 integrin. Microbiology. 1994 Nov;140 ( Pt 11):2971-9.

http://www.nejm.org/doi/full/10.1056/NEJMoa033114#t=article

Sobel JD, Wiesenfeld HC, Martens M, et al. Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis. N Engl J Med. 2004b Aug 26;351(9):876-83.

https://www.medicines.org.uk/emc/medicine/1344

Voltarol Suppositories 12.5 mg, 25 mg, 50 mg, 100 mg, UK SmPC 2013

Other Identifiers

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ProF-001_Phase IIa

Identifier Type: -

Identifier Source: org_study_id

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