National Observational Study of Clinical Practices in Deceased Organ Donation
NCT ID: NCT03114436
Last Updated: 2019-05-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
622 participants
OBSERVATIONAL
2016-08-31
2018-07-31
Brief Summary
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Detailed Description
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The Canada-DONATE study is designed to develop a national platform for future clinical trials in deceased donor care. The main objectives include:
1. Establish specialized organ donation research teams at participating ICUs.
2. Observe, record, and describe ICU practices in deceased donor care (e.g., donor resuscitation, organ suitability assessments, death declaration) which are likely to vary by site, region and province and will be very important to inform clinical care protocols for future RCTs.
3. Engage and work with ODOs from each province to foster data sharing and develop procedures to enhance efficiency in future RCTs.
4. Investigate the comparative effectiveness of various ICU interventions in deceased donor care to improve the conversion of consented donors to actual donors and to improve the number of transplants per donor.
5. Produce specific knowledge translation tools that will serve in the future as clinical tools to enhance ICU care and research tools to facilitate RCTs.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Consented deceased organ donors
Includes neurological determination of death (DND) and by circulatory determination of death (DCD).
Observational Data Collection
All aspects of deceased donor care in the ICU.
Interventions
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Observational Data Collection
All aspects of deceased donor care in the ICU.
Eligibility Criteria
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Inclusion Criteria
* Consent has been obtained for Organ Donation
Exclusion Criteria
ALL
No
Sponsors
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Canadian Critical Care Trials Group
OTHER
Canadian National Transplant Research Program
OTHER
Transplant Quebec
UNKNOWN
Trillium Gift of Life Network
UNKNOWN
BC Transplant
UNKNOWN
Southern Alberta Organ Donation Program
UNKNOWN
Human Organ Procurement and Exchange
UNKNOWN
Canadian Blood Services
OTHER
Hamilton Health Sciences Corporation
OTHER
McMaster University
OTHER
Responsible Party
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Maureen O. Meade
Research Program Director
Principal Investigators
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Frederick D'Aragon, MD, MSc
Role: PRINCIPAL_INVESTIGATOR
Université de Sherbrooke
Maureen O Meade, MD, MSc
Role: STUDY_DIRECTOR
McMaster University
Locations
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Foothills Medical Centre
Calgary, Alberta, Canada
Royal Alexandra Hospital
Edmonton, Alberta, Canada
University of Alberta Hospital
Edmonton, Alberta, Canada
Royal Columbian Hospital
New Westminster, British Columbia, Canada
Vancouver General Hospital
Vancouver, British Columbia, Canada
St. Paul's Hospital
Vancouver, British Columbia, Canada
Royal Jubilee Hospital
Victoria, British Columbia, Canada
Victoria General Hospital
Victoria, British Columbia, Canada
Hamilton Health Sciences - Hamilton General Hospital
Hamilton, Ontario, Canada
Hamilton Health Science - Juravinski Hospital
Hamilton, Ontario, Canada
Kingston General Hospital
Kingston, Ontario, Canada
London Health Sciences Centre - University Hospital
London, Ontario, Canada
London Health Sciences Centre - Victoria Hospital
London, Ontario, Canada
Trillium Health Partners - Trillium Health Centre
Mississauga, Ontario, Canada
The Ottawa Hospital - Civic Campus
Ottawa, Ontario, Canada
The Ottawa Hospital - General Hospital
Ottawa, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
St Michael's Hospital
Toronto, Ontario, Canada
University Health Network - Toronto General Hospital
Toronto, Ontario, Canada
University Health Network - Toronto Western Hospital
Toronto, Ontario, Canada
Hôpital Maisonneuve-Rosemont
Montreal, Quebec, Canada
Centre hospitalier de l'Université de Montréal - Hôpital Notre-Dame
Montreal, Quebec, Canada
Centre hospitalier de l'Université de Montréal - Hôtel-Dieu de Montréal
Montreal, Quebec, Canada
Centre hospitalier de l'Université de Montréal - Hôpital Saint-Luc
Montreal, Quebec, Canada
Centre Universitaire de Santé McGill/McGill University Health Centre - Hôpital Général de Montreal
Montreal, Quebec, Canada
Centre Universitaire de Santé McGill/McGill University Health Centre - Hôpital Royal Victoria
Montreal, Quebec, Canada
Hôpital du Sacré-Cœur de Montréal
Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada
Centre Hospitalier Universitaire de Québec - Université Laval
Québec, , Canada
Countries
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References
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D'Aragon F, Lamontagne F, Cook D, Dhanani S, Keenan S, Chasse M, English S, Burns KEA, Frenette AJ, Ball I, Boyd JG, Masse MH, Breau R, Akhtar A, Kramer A, Rochwerg B, Lauzier F, Kutsogiannis DJ, Ibrahim Q, Hand L, Zhou Q, Meade MO; Canadian Critical Care Trials Group and the Canadian Donation and Transplant Research Program. Variability in deceased donor care in Canada: a report of the Canada-DONATE cohort study. Can J Anaesth. 2020 Aug;67(8):992-1004. doi: 10.1007/s12630-020-01692-7. Epub 2020 May 8.
D'Aragon F, Dhanani S, Lamontagne F, Cook DJ, Burns K, Akhtar A, Chasse M, Frenette AJ, Keenan S, Lize JF, Kutsogiannis DJ, Kramer A, Hand LE, Arseneau E, Masse MH, Ribic C, Ball I, Baker A, Boyd G, Rochwerg B, Healey A, Hanna S, Guyatt GH, Meade MO; Canadian Critical Care Trials Group and the Canadian National Transplant Research Program. Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors. BMJ Open. 2017 Sep 28;7(9):e018858. doi: 10.1136/bmjopen-2017-018858.
Related Links
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Canada-DONATE Research Progam Website
Other Identifiers
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Canada-DONATE 0780-PIA
Identifier Type: -
Identifier Source: org_study_id
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